A small animal multi-platform water environment sleep deprivation tank and system

A technology of sleep deprivation and small animals, applied in the field of medical experiments, can solve problems such as affecting experimental efficiency, increasing unfavorable factors, hindering experimental design, etc., achieving high experimental efficiency, strong operability, and avoiding biological instability and other factors. the effect of interference

Active Publication Date: 2022-07-22
XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
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  • Claims
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Problems solved by technology

But whether the 2 weeks before the experiment has caused a lot of interference to the experiment itself, such as body weight and other factors, this just hinders the specific experimental design
[0005] And currently commercially available such devices (such as figure 1 ) mostly followed the design of the multi-platform sleep deprivation method, but in the experimental process, first of all, the pre-mixing of about 2 weeks before the experiment could not be fully satisfied, so that the experiment had the interference of uncertain factors; secondly, the experiment used The water tank is huge (about 120×65×45㎝ or even larger), and it is not easy to operate, and the number of more than a dozen small platforms affects the experimental efficiency; the height of the small platform is higher (about 10-15㎝), and the water demand is larger. Due to the deep water, it is very easy to cause the drowning of animals; the material of the small platform is mostly plastic, and rodents will bite it when stimulated; during the experiment, the experimental animals cannot freely eat and drink , adding unfavorable factors to the experiment

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  • A small animal multi-platform water environment sleep deprivation tank and system
  • A small animal multi-platform water environment sleep deprivation tank and system
  • A small animal multi-platform water environment sleep deprivation tank and system

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Embodiment 1

[0069] Sleep deprivation system for rats, including stainless steel frame, water tank, water inlet and outlet, and controls. There are 4 layers in the frame, and 2 water tanks are placed on each layer, with a total of 8 water tanks, which can simultaneously satisfy 40 rats weighing 200g to perform sleep deprivation experiments at the same time. The size of the bottom surface of the water tank is 500×350mm, the upper mouth is 545×395mm, and the height is 200mm. A circular platform with a diameter of 60mm is arranged at the inner bottom, the platform height is 50mm, and the diameter of the vertical pipe supporting the platform is 10mm. The platform and standpipe are made of stainless steel with a thickness of 3mm. The number of platforms is 6, the platform is 100mm away from the water tank wall, and the distance between the platforms is 150mm. Each water tank is provided with a water inlet on the side of the box, which is connected to the water inlet pipe, and the distance bet...

Embodiment 2

[0074] Sleep deprivation system for rats, including stainless steel frame, water tank, water inlet and outlet, and controls. There are 5 layers in the rack body, 2 water tanks are placed on each layer, there are 10 water tanks in total, which can satisfy 50 rats weighing 150 grams to perform sleep deprivation experiments at the same time. The size of the bottom surface of the water tank is 500×350mm, the upper mouth is 545×395mm, and the height is 200mm. A circular platform with a diameter of 50mm is set at the inner bottom, the platform height is 55mm, and the diameter of the vertical pipe supporting the platform is 13mm. The platform and standpipe are made of stainless steel with a thickness of 5mm. The number of platforms is 6, the platform is 100mm away from the water tank wall, and the distance between the small platforms is 150mm. Each water tank is provided with a water inlet on the side of the box, which is connected to the water inlet pipe, and the distance between ...

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Abstract

The invention belongs to the technical field of medical experiments, and provides a small animal multi-platform water environment sleep deprivation water tank and system. The bottom of the sleep deprivation water tank of the present invention is provided with a platform; the sleep deprivation system includes a frame body, a sleep deprivation water tank, a water inlet and outlet device, and a control device for controlling experiment time, sewage discharge and cleaning. The water tank and system of the invention avoids the interference of biological instability and other factors in the sleep deprivation experiment, and the experimental results are stable and repeatable; the equipment has strong operability, high space utilization rate and good application effect.

Description

technical field [0001] The invention belongs to the technical field of medical experiments, and relates to a sleep deprivation device. Background technique [0002] The sleep deprivation method is widely used in the basic research of Chinese and Western medicine. Sleep deprivation can not only cause changes in biological mood, memory, etc. [1] , and can also cause changes in the expression of hormones, neurotransmitters, genes and even some specific proteins [2] Therefore, sleep deprivation is not only one of the important methods to study the function and mechanism of sleep [3] , and is also a typical endogenous oxidative stressor [3] , some scholars believe that it is a pathogenic factor consistent with social pressure [5] . TCM scholars were the first to use the water environment platform sleep deprivation method to establish a model of heart deficiency syndrome, which has been widely used [6-7] . [0003] The quality of sleep deprivation conditions will directly a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01K1/03
CPCA01K1/031
Inventor 刘建勋陈进成林成仁任钧国王磊沙甘加宽
Owner XIYUAN HOSPITAL OF CHINA ACAD OF CHINESE MEDICAL SCI
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