A kind of inorganic-inorganic nano-hybrid material with double mesoporous core-shell structure and its preparation method and application

A core-shell structure and hybrid material technology, applied in the field of nano-hybrid materials and their preparation, can solve the problems of component stability, insufficient consistency, cumbersome preparation methods, and difficult industrialization, and achieve biomedical application prospects. The effect of broad, few process steps and easy process control

Active Publication Date: 2019-06-25
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current commercial magnetic resonance contrast agents have the disadvantages of long relaxation time and short cycle period, and the stability and consistency of their components are insufficient, and the preparation method is relatively cumbersome, making industrialization difficult.

Method used

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  • A kind of inorganic-inorganic nano-hybrid material with double mesoporous core-shell structure and its preparation method and application
  • A kind of inorganic-inorganic nano-hybrid material with double mesoporous core-shell structure and its preparation method and application
  • A kind of inorganic-inorganic nano-hybrid material with double mesoporous core-shell structure and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The platinum-gadolinium nano-hybrid material with dual mesoporous core-shell structure and its preparation method provided in this embodiment comprise the following steps:

[0031] (1) Using N, N-dimethylhexadecyl ammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce chloroplatinic acid to synthesize mesoporous inorganic platinum nanoparticles: 80 mg surface Active agent N,N-dimethylhexadecyl ammonium bromide sodium acetate (OTAB-Na) was added to 10mL deionized water, heated to 70°C to dissolve, then added 2mL0.01mol / L chloroplatinic acid aqueous solution and 2mL0. 2 mol / L fresh ascorbic acid aqueous solution, stirred for 3 hours, centrifuged, washed, and the product was dissolved in deionized water to form a dispersion of mesoporous platinum nanoparticles.

[0032] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap mesoporous silica shell on the surface of mesoporous inorganic nanoparticles, and then remove CTAB to ...

Embodiment 2

[0040] The palladium-gadolinium nano-hybrid material with dual mesoporous core-shell structure and its preparation method, material and application provided in this example are basically the same as those in Example 1, except that it includes the following steps:

[0041] (1) Using N,N-dimethylhexadecyl ammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce palladium chloride to synthesize mesoporous inorganic palladium particles: 100mg surface active The solution (OTAB-Na) was added to 10 mL of deionized water, heated to 50°C to dissolve, then 1 mL of 0.01 mol / L palladium chloride aqueous solution and 1 mL of 0.2 mol / L fresh ascorbic acid aqueous solution were added, stirred for 1 h, centrifuged, washed, and the product was dissolved. In deionized water, a dispersion of mesoporous palladium nanoparticles was formed.

[0042] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap mesoporous silica shell on the surface of mesopor...

Embodiment 3

[0046] The gold-gadolinium nano-hybrid material with dual mesoporous core-shell structure and its preparation method, material and application provided in this example are basically the same as those in Example 1 or 2, except that it includes the following steps:

[0047] (1) Using N,N-dimethylhexadecyl ammonium bromide sodium acetate (OTAB-Na) as a surfactant, using ascorbic acid to reduce chloroauric acid to synthesize mesoporous inorganic gold particles: 90mg surface active Add the agent (OTAB-Na) into 10mL deionized water, heat up to 100°C to dissolve, then add 1.5mL 0.01mol / L chloroauric acid aqueous solution and 1.5mL 0.2mol / L fresh ascorbic acid aqueous solution, stir for 2h, centrifuge, wash, The product is dissolved in deionized water to form a dispersion of mesoporous gold nanoparticles.

[0048] (2) Using cetyltrimethylammonium bromide (CATB) as a surfactant, wrap mesoporous silica shell on the surface of mesoporous inorganic nanoparticles, and then remove CTAB to o...

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Abstract

The invention discloses an inorganic-inorganic nano hybrid material of a bimodal mesoporous core-shell structure as well as a preparation method and an application of the inorganic-inorganic nano hybrid material. The bimodal mesoporous inorganic-inorganic nano hybrid material of the core-shell structure is prepared by the following steps: firstly, with the presence of a surfactant, reducing metal salt by virtue of ascorbic acid, so that mesoporous inorganic nanoparticles are obtained; then, covering the surface of hexadecyl trimethyl ammonium bromide, which serves as a surfactant, with a layer of mesoporous silicon dioxide; covalently grafting diethyltriamine pentaacetic acid after modifying a mesoporous silicon dioxide shell layer by virtue of amino; and finally, coordinating with metal ions, so that the bimodal mesoporous inorganic-inorganic nano hybrid material of the core-shell structure is obtained. The prepared material has the core-shell material, wherein a core is constituted by the mesoporous inorganic nanoparticles and a shell is formed by the mesoporous silicon dioxide shell layer, and the surface of the mesoporous silicon dioxide shell layer is hybridized and modified by virtue of inorganic metals. The inorganic-inorganic nano hybrid material has the advantages of being uniform in dimension, good in biocompatibility and the like, and the inorganic-inorganic nano hybrid material is high in optical stability, high in photo-thermal conversion rate and high in magnetic resonance imaging resolution ratio; and integration of magnetic resonance imaging and photo-thermal therapy can be achieved.

Description

technical field [0001] The invention relates to a nano hybrid material and its preparation method and application, in particular to a core-shell structure double mesoporous inorganic-inorganic nano hybrid material and its preparation method and application. Background technique [0002] In recent years, cancer is one of the important causes of human death, and the detection and treatment of tumors has always been a major problem that plagues people. At present, the main treatment methods are chemotherapy and radiotherapy, but their serious side effects cannot be ignored. The detection and targeted treatment of tumors are even more urgent. Photothermal therapy uses near-infrared light excitation, which has a large penetration depth. It is an emerging and effective treatment method in recent years. However, some photothermal reagents that have been reported have the disadvantages of poor photostability and low photothermal conversion rate. Therefore, it is of great significa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/18A61K41/00A61K47/69A61K47/54A61K47/52A61P35/00
CPCA61K41/0052A61K49/1833
Inventor 孙丽宁施利毅赵磊李海宏刘金亮赵慧君
Owner SHANGHAI UNIV
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