Method of using umbilical cord blood stem cells to treat muscular dystrophy

A technology for umbilical cord blood stem cells and muscular dystrophy, applied in the medical field, can solve problems such as inability to correct genetic mutations, and achieve the effect of good transplant ability

Inactive Publication Date: 2017-05-31
溯源生命科技股份有限公司
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  • Abstract
  • Description
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Problems solved by technology

However, these treatments cannot correct the ge

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  • Method of using umbilical cord blood stem cells to treat muscular dystrophy

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Embodiment Construction

[0042] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with specific embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, and are not intended to limit the present invention.

[0043] see figure 1 , the specific embodiment adopts the following technical scheme: a method for treating muscular dystrophy with umbilical cord blood stem cells, which comprises the following steps:

[0044] (S1) Obtain HLA-matched umbilical cord blood;

[0045] (S2) Enriching CD34+ cells according to the immunomagnetic bead method;

[0046] (S3) After non-myeloablative treatment, transplant 50% of CD34+ cells and all CD34- cells into the patient;

[0047] (S4) The remaining 50% of CD34+ cells are converted into muscle stem cells by increasing the transformation efficiency through factor combinati...

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Abstract

The invention provides a method of using umbilical cord blood stem cells to treat muscular dystrophy, and relates to the technical field of medical technology. The method comprises the steps of obtaining HLA fitted umbilical cord blood; based on the immunomagnetic bead method, enriching CD34+ cells; after myeloablative treatment, transplanting 50% of the CD34+ cells and all CD34- cells into a patient's body; increasing the conversion rate of the remaining 50% of the CD34+ cells through factor combination to transform the umbilical cord blood stem cells into muscle stem cells; and transplanting the middle stem cells to the patient. The transplanted muscle stem cells differentiate into functional muscle stem cells, and the muscle stem cells propagate and differentiate into muscle tissues. The hemopoietic stem cells can be converted into muscle stem cells, and the muscle stem cells originating from the differentiation of umbilical cord blood stem cells are transplanted, and therefore the method has a good transplantation capability and can improve or cure myotrophy sickness.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for treating muscular dystrophy with umbilical cord blood stem cells. Background technique [0002] Muscular dystrophy (MD) refers to a group of inherited muscle diseases in which the muscles of the human body become weak. Muscular dystrophy is characterized by progressive skeletal muscle weakness, muscle protein defects, and death of muscle cells and tissues. [0003] Pseudohypertrophic muscular dystrophy (DMD), also known as Duchenne muscular dystrophy (DMD), is the most common form of progressive muscular dystrophy in children and is clinically apparent when a child begins to walk , patients are usually unable to walk normally by the age of 10 to 12, need to use a wheelchair, and generally die between the teens and twenties. In males, the incidence of Duchenne muscular dystrophy (DMD) is 1 in 3500. [0004] In the field of gene therapy, despite intensive animal exp...

Claims

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Application Information

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IPC IPC(8): A61L27/38
CPCA61L27/3834A61L27/3873A61L2430/30
Inventor 张孝兵袁卫平万谦
Owner 溯源生命科技股份有限公司
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