Cancer individuation intervention strategy selection method based on molecular physiome
A molecular and physiological technology, applied in the field of individualized cancer intervention strategy selection based on individual molecular physiological omics data, can solve the problems of high research and development costs, heavy workload of new drug development, and diminishing average returns, so as to improve survival rate and intervention Response rate, improving intervention response, avoiding marginal effects
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Embodiment 1
[0039] Example 1: Lovastatin selectively induces apoptosis in multiple myeloma cell lines--sample matching based on biological pathways related to the drug's mode of action
[0040] In this example, the transcriptome expression profile data (PMID: 20360469) of 4 multiple myeloma cell lines before and after lovastatin treatment published by Clendening JW et al. were collected online. Among them, H929 and KMS11 were lovastatin-sensitive cell lines, and apoptosis occurred 12 hours after adding lovastatin. LP1 and SKMM1 are lovastatin-insensitive cell lines, which do not undergo apoptosis after adding lovastatin.
[0041] In this example, the multiple myeloma cell line H929 was used as a cell line with a known phenotype after drug treatment (that is, the model responding to lovastatin in the drug response model library), and the other three groups of multiple myeloma cell lines KMS11, LP1 and SKMM1 were used as cell lines with unknown post-treatment phenotypes (ie new cases).
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Embodiment 2
[0054] Example 2: Lovastatin selectively induces apoptosis of multiple myeloma cell lines--sample matching based on expression profile data before and after model drug response in the model library
[0055] The source of data in this example is the same as that in Example 1, using the transcriptome expression profile data of four multiple myeloma cell lines before and after lovastatin treatment published by Clendening JW et al. This example mainly utilizes the characteristic signal molecules of H929 in response to drugs before and after administration of lovastatin, and provides another way of matching with the drug response model.
[0056] In this example, the difference in expression profile of H929 before and after administration of lovastatin was compared, and the 100 genes with the most significant difference in expression profile were also ranked according to the significance of the difference as the characteristic signal molecules of the characteristic class for drug res...
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