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Method for predicting residue of metabolite-related sulfamonomethoxine in pig

A technology for sulfamethoxine and metabolites, which is applied in the field of prediction of sulfamethoxine residues in pigs, and can solve problems such as model prediction failure

Active Publication Date: 2017-07-18
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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Problems solved by technology

However, many veterinary drugs are metabolized in animals, and only considering the prototype drugs often leads to invalid model predictions

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  • Method for predicting residue of metabolite-related sulfamonomethoxine in pig
  • Method for predicting residue of metabolite-related sulfamonomethoxine in pig
  • Method for predicting residue of metabolite-related sulfamonomethoxine in pig

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Embodiment Construction

[0083] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments.

[0084] A method for predicting residues of sulfamethoxine in pigs involving metabolites, comprising the following steps:

[0085](1) According to the reported pharmacokinetic results of sulfamethoxine in pigs, in order to simplify the model, the assumptions of the model are as follows: after intramuscular injection, the absorption of sulfamethoxine in pigs obeys the first-order rate, It obeys blood flow rate-limiting distribution in various tissues and organs; sulfamethoxine can undergo acetylation and deacetylation metabolism in pig liver, and all metabolic reactions obey the first-order rate; sulfamethoxine and its acetylation metabolism The substance is excreted through bile and urine at a first-order rate.

[0086] According to the above assumptions, if figure 1 As shown, the established model structure is: including two parts of sulfame...

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Abstract

The invention discloses a method for predicting a residue of metabolite-related sulfamonomethoxine in a pig. The method comprises the following steps of (1) supposing a physiologic pharmacokinetic model of the pig and establishing a model structure; (2) establishing a mass-balance equation of the sulfamonomethoxine and acetylated metabolites thereof in various tissues in the pig according to the established model structure; (3) collecting physiological anatomical parameters of the pig and specific parameters of the sulfamonomethoxine and the acetylated metabolites thereof, carrying out model fitting according to the measured data to obtain a final value of the model parameter and finishing establishing of the model; and (4) inputting sulfamonomethoxine dose for pig injection, running the model to obtain predicted values of the residual concentration of the sulfamonomethoxine in various tissues of the pig at different time points after medication. The established physiologic pharmacokinetic model relates to metabolites of the sulfamonomethoxine in the pig, the physiologic pharmacokinetic model is closer to the true situation and the predicted result is more accurate.

Description

technical field [0001] The invention relates to the field of food safety risk monitoring, in particular to a method for predicting residues of sulfamethoxine in pigs involving metabolites. Background technique [0002] Sulfonamides have a broad antibacterial spectrum and are widely used in the swine industry to prevent Gram-positive and Gram-negative bacterial infections. However, in actual production, due to the drive of economic interests and the pressure of complex livestock disease prevention and control, farms often use excessive amounts and ranges of antimicrobials. Residual accumulation of sulfa drugs will enter the human body through the biological chain, causing symptoms such as kidney damage, allergic reactions, hematopoietic dysfunction, digestive system disorders, and central nervous system disorders, and even potentially causing the danger of "teratogenic, carcinogenic, and mutagenic". The abuse of sulfonamides can also lead to increased drug resistance of zoon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/48G06F19/00
CPCG01N33/48
Inventor 张巧艳杨波郭辉杨胜利林晶毛江昌商小金黄娟朱凤香陈亭亭
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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