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Method for predicting residue of ciprofloxacin in pig body by physiologically based pharmacokinetic model

A technology of physiological pharmacokinetics and ciprofloxacin, applied in the field of food safety risk assessment, can solve the problems of false positives, high cost and low cost, and achieve the effect of reducing economic loss and cost

Active Publication Date: 2017-08-25
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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Problems solved by technology

[0003] Aiming at the shortcomings of false positives and high cost in the prior art, the present invention provides a method for predicting ciprofloxacin residue in pigs with a physiological pharmacokinetic model, which is simple, feasible and low in cost

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  • Method for predicting residue of ciprofloxacin in pig body by physiologically based pharmacokinetic model
  • Method for predicting residue of ciprofloxacin in pig body by physiologically based pharmacokinetic model
  • Method for predicting residue of ciprofloxacin in pig body by physiologically based pharmacokinetic model

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Embodiment 1

[0034] A method for predicting ciprofloxacin residues in pigs by a physiological pharmacokinetic model, comprising the following steps:

[0035] Ciprofloxacin is a small molecule substance. For drug residues, we focus on the drug concentration in edible tissues and vital organs, so the model established does not include organs with special physiological barriers. Ciprofloxacin has high fat solubility and strong permeability, and its distribution and transport in the body mainly depends on the blood perfusion rate. Therefore, it can be assumed that the absorption of ciprofloxacin obeys the first-order rate after intramuscular injection, and the distribution in various tissues and organs The speed and degree mainly depend on the blood flow flowing through the tissues and organs, which obeys the speed-limiting distribution of blood flow, is excreted by the kidneys, and obeys the first-order rate. The chamber of the physiological pharmacokinetic model described in the present inve...

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Abstract

The invention relates to the field of food safety risk assessment, and discloses a method for predicting the residue of the ciprofloxacin in a pig body by a physiologically based pharmacokinetic model. The method comprises the following steps that: (1) collecting the physiological dissection parameter of the pig; (2) obtaining the compound specificity parameters of the ciprofloxacin in the pig body; (3) utilizing acslXtreme software to establish a six-chamber model; and (4) evaluating the model. By use of the method, the six-chamber physiologically based pharmacokinetic model is established, the residue elimination curve of the ciprofloxacin in the muscle, the fat, the liver and the kidney of the pig is successfully fit, and a prediction result is matched with actual measurement data. The physiologically based pharmacokinetic model constructed by the method can predict the dynamic change of the ciprofloxacin in the edible tissues of the pig under different exposure situations, is especially suitable for the residue monitoring of the ciprofloxacin under a label external use situation, and has the advantages that monitoring cost is lowered and operation is convenient.

Description

technical field [0001] The invention relates to the field of food safety risk assessment, in particular to a method for predicting ciprofloxacin residues in pigs with a physiological pharmacokinetic model. Background technique [0002] Ciprofloxacin has excellent antibacterial effect and pharmacokinetic properties, and is widely used in the pig industry to prevent and control Gram-negative bacteria and mycoplasma infection. Unreasonable use of ciprofloxacin can lead to its residue in the edible tissues of pigs, endangering the health of consumers and the sustainable development of the pig industry. Although the Ministry of Agriculture of my country stipulates the maximum dosage, maximum residue limit and withdrawal period of ciprofloxacin, this cannot effectively eliminate the residue of ciprofloxacin in various off-label applications. The traditional "sampling-slaughter-testing-judgment" residue monitoring method has a certain risk of false positives, and the monitoring co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/00
CPCG16Z99/00
Inventor 张巧艳杨波杨华林晶商小金毛江昌朱凤香
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
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