Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A method for predicting residues of sulfamethoxine in pigs involving metabolites

A technology for sulfamethoxine and metabolites, which is applied in the field of prediction of sulfamethoxine residues in pigs, and can solve problems such as model prediction failure

Active Publication Date: 2019-04-16
ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many veterinary drugs are metabolized in animals, and only considering the prototype drugs often leads to invalid model predictions

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for predicting residues of sulfamethoxine in pigs involving metabolites
  • A method for predicting residues of sulfamethoxine in pigs involving metabolites
  • A method for predicting residues of sulfamethoxine in pigs involving metabolites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0083] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments.

[0084] A method for predicting residues of sulfamethoxine in pigs involving metabolites, comprising the following steps:

[0085](1) According to the reported pharmacokinetic results of sulfamethoxine in pigs, in order to simplify the model, the assumptions of the model are as follows: after intramuscular injection, the absorption of sulfamethoxine in pigs obeys the first-order rate, It obeys blood flow rate-limiting distribution in various tissues and organs; sulfamethoxine can undergo acetylation and deacetylation metabolism in pig liver, and all metabolic reactions obey the first-order rate; sulfamethoxine and its acetylation metabolism The substance is excreted through bile and urine at a first-order rate.

[0086] According to the above assumptions, if figure 1 As shown, the established model structure is: including two parts of sulfame...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for predicting residues of sulfamethoxine in pigs involving metabolites, comprising the following steps: (1) assuming a physiological pharmacokinetic model of pigs and establishing the model structure; (2) according to the established model structure , to establish the mass balance equations of sulfamethoxine and its acetylated metabolites in various tissues in pigs; (3) collect the physiological and anatomical parameters of pigs and the specific parameters of sulfamethoxine and its acetylated metabolites, Carry out model fitting according to the measured data, obtain the final value of the model parameters, and complete the establishment of the model; (4) After inputting the dose of sulfamethoxine injected into the pig, run the model, and then obtain the Predicted values ​​of sulfamethoxine residual concentrations. The physiological pharmacokinetic model established by the invention relates to the metabolites of sulfamethoxine in pigs, the physiological pharmacokinetic model is closer to the real situation, and the prediction result is more accurate.

Description

technical field [0001] The invention relates to the field of food safety risk monitoring, in particular to a method for predicting residues of sulfamethoxine in pigs involving metabolites. Background technique [0002] Sulfonamides have a broad antibacterial spectrum and are widely used in the swine industry to prevent Gram-positive and Gram-negative bacterial infections. However, in actual production, due to the drive of economic interests and the pressure of complex livestock disease prevention and control, farms often use excessive amounts and ranges of antimicrobials. Residual accumulation of sulfa drugs will enter the human body through the biological chain, causing symptoms such as kidney damage, allergic reactions, hematopoietic dysfunction, digestive system disorders, and central nervous system disorders, and even potentially causing the danger of "teratogenic, carcinogenic, and mutagenic". The abuse of sulfonamides can also lead to increased drug resistance of zoon...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48G16B5/30
CPCG01N33/48
Inventor 张巧艳杨波郭辉杨胜利林晶毛江昌商小金黄娟朱凤香陈亭亭
Owner ZHEJIANG ACADEMY OF AGRICULTURE SCIENCES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com