Use of aloeemodin in preparing of medicament for preventing and treating myocardial ischemia and arrhythmia
A technology of aloe-emodin and myocardial ischemia, which is applied in the field of medicine to achieve the effect of high cost performance, reversal of QT interval prolongation, and low price
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Embodiment 1
[0030] Example 1 Pharmacodynamic study of aloe-emodin anti-acute myocardial ischemia
[0031] 1 Experimental method:
[0032] 24 male Kunming mice were randomly divided into four groups: normal control group, myocardial ischemia group, aloe-emodin pretreatment group (myocardial infarction+100mg aloe-emodin / kg mouse body weight), aloe-emodin alone group (100mg aloe-emodin Emodin / kg mouse body weight), 6 mice in each group. In the myocardial ischemia group, the left anterior descending coronary artery was ligated to establish a myocardial ischemia model. After 3 days, the heart function was detected, and the myocardial infarct size was measured. In the aloe-emodin group, 100 mg aloe-emodin / kg mouse body weight was administered orally to the mice for 2 consecutive weeks, and then the left anterior descending coronary artery was ligated to establish a myocardial ischemia model. During the ischemia period, the intragastric administration was continued, and the cardiac function was...
Embodiment 2
[0035] Example 2 Pharmacodynamic study of aloe-emodin against arrhythmia
[0036] 1 Experimental method:
[0037] Rat models of hyperlipidemia were established by feeding with high-fat diet. Among them, except that the control group was fed with ordinary feed at 20 g / bird / day, the rest of the groups were fed with high-fat feed at 20 g / bird / day and had free access to water. The rats were fed continuously for 4 weeks to establish a hyperlipidemia model. After the model was successfully established, aloe-emodin (100 mg / kg) or atorvastatin (7.2 mg / kg) was administered by intragastric administration, and the control group and the high-fat model group were treated with pure water intragastric administration once a day. The volume of each administration was calculated according to the weight of the rats at 1 mL / 100 g, and the administration was administered for 6 weeks. During the administration period, the control group was still fed with common feed, and the other groups were stil...
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