30results about How to "Strong medicinal properties" patented technology

Belonging to the field of medical technologies, the present invention discloses application of aloe-emodin in preparation of drugs reducing blood lipid and liver lipid. Specifically, blood lipid refers to total cholesterol and low density lipoprotein in serum, and liver lipid refers to total cholesterol in liver. Toxicity tests show that aloe-emodin has no obvious toxic and side effect. Pharmacodynamic tests of aloe-emodin show that aloe-emodin can significantly reduce the total cholesterol and low density lipoprotein in hyperlipidemia animal model serum, and has obvious blood lipid reducing effect. At the same time, aloe-emodin can also significantly reduce the total cholesterol content of a hyperlipidemia animal model liver, and has obvious liver lipid reducing effect. Therefore, the invention puts forward the application of aloe-emodin in reduction of blood lipid and liver lipid, aloe-emodin has the characteristics of significant lipid reducing effect, low toxicity, no irritation, low price, and convenient production, transportation, storage and taking, and can have broad application prospects as a blood lipid and liver lipid reducing drug.

The invention discloses applications of an emodin succinyl ester compound in preparing lipid-lowering medicines, belonging to the technical field of medicines. The emodin succinyl ester compound has the structure (R is C1-5 alkyls) as shown in the formula I. The pharmacological experiment is carried out on the experiment mixed type rats with hyperlipemia, and the result proves that the emodin succinyl ester compound provided by the invention is superior to emodin, and has the advantages that the lipid-lowering effect is obvious, the safety is good, the medication is simple and convenient, theraw materials are cheap and easily available, and the transportation and storage are convenient. The emodin succinyl ester compound provided by the invention has the wide application prospect in the field of preparation of the lipid-lowering medicines.

The invention discloses application of an emodin succinyl ester compound in preparation of a medicine for resisting myocardial ischemia and belongs to the technical field of medicines. The emodin succinyl ester compound has a structure shown as a formula I (R is C1 to C5 alkyl). Pharmacological experiments on rats and mice for experimenting myocardial infarction prove that the emodin succinyl ester compound has the advantages of remarkable myocardial ischemia resisting effect, good safety, simplicity and convenience for drug utilization, low raw material price and easiness for obtaining, and convenience for transportation and preservation. The emodin succinyl ester compound disclosed by the invention is used as a myocardial ischemia resisting drug and has a wide application prospect. The formula I is shown in the description.

The invention relates to an external traditional Chinese medicinal healthcare preparation with effects of beautifying features, relieving pain and relieving itching and a preparation method thereof. The effective ingredient of the traditional Chinese medicinal preparation is prepared from the following raw materials in parts by weight: 5-10 parts of pseudo-ginseng, 10-20 parts of costus roots, 10-20 parts of sappanwood, 10-20 parts of radix angelicae lateralis preparata, 10-20 parts of myrrh, 10-20 parts of coptis chinensis, 10-20 parts of cortex phellodendri, 10-20 parts of flos carthami, 20-30 parts of pittosporum roots, 20-30 parts of rheum officinale, 20-30 parts of mint, 5-10 parts of borneol, 10-20 parts of lithospermum purpurocaeruleum, 20-30 parts of salviae miltiorrhizae, 10-20 parts of philippine flemingia roots, 8-12 parts of rhizoma corydalis, 10-20 parts of menthol, 20-30 parts of shinyleaf pricklyash roots and 10-20 parts of honeysuckles. The external traditional Chinese medicinal healthcare preparation can play a role in quickly beautifying the features when externally used, has the effects of relieving pain and relieving itching vigorously, and has an obvious curative effect of quickly relieving pain on trauma symptoms of a traumatic injury, a knife wound, a burn and a scald.

The invention relates to the field of health-care tea drinks, specifically to anoectochilus formosanus tea and a making technology thereof. According to the technical key points, the anoectochilus formosanus tea comprises anoectochilus formosanus, Cortex moutan, rhizoma corydalis, pseudo-ginseng, Chinese magnoliavine, red sage root, anemarrhena, gynostemma pentaphylla, dendrobium and an auxiliaryagent. The making technology comprises the following steps: selecting fresh anoectochilus formosanus and removing impurities and soil, rinsing with clear water and air-drying, cutting into strips of 3-5 mm long, putting the strips into a fermentation tank and fermenting; taking the fermented anoectochilus formosanus out and drying in a baking oven to prepare dried anoectochilus formosanus, preparing a mixed solution, mixing the mixed solution and the dried anoectochilus formosanus, heating by water bath until water content of the dried anoectochilus formosanus is 3-5%, and cooling to room temperature so as to prepare the anoectochilus formosanus tea. By the making technology, nutrients are not easy to break, yield is high, energy consumption is low, cost of the extraction process is low, economical benefit is remarkably enhanced, and it is ensured that effective ingredients of the product are not destroyed. The making technology is good for promotion of the anoectochilus formosanus product.

The invention discloses a preparation method of flower and plant wine. The method comprises the following steps of: (1) weighing glutinous rice, lotus seeds and peach kernels in the weight ratio of 1: (0.05-0.1): (0.01-0.05), processing the lotus seeds and the peach kernels into powder, cooking thoroughly the powder and the glutinous rice together, and cooling the cooked materials to room temperature to obtain cooked main ingredients; (2) adding yeast, the weight of which is 0.1%-1% of that of the glutinous rice, to the cooked main ingredients, carrying out saccharification on the main ingredients, adding water, the weight of which is 4-7 times that of the glutinous rice, to the ingredients, carrying out fermentation on the ingredients, filtering the fermented ingredients to take filtrate to obtain a wine sample, wherein the time of saccharification and the time of fermentation are both 48-72 hours; (3) adding spirit, cane sugar, lotus flowers, honeysuckle, lotus leaves and brunella vulgaris linne, which are respectively 10%-15%, 5%-8%, 3%-5%, 2%-4%, 2%-4% and 1%-3% of the glutinous rice in weight, to the wine sample, uniformly mixing the materials, sterilizing the mixture, and sealing and soaking the mixture for 1-6 months to obtain soaked wine; and (4) filtering the soaked wine, and bottling the filtered wine to obtain the flower and plant wine. The flower and plant wine prepared by the method is low in alcohol degree and good in mouthfeel, and has unique flower and plant faint scent and the efficacies of protecting liver and stomach and clearing away heat and toxic materials.

The invention discloses a lucid ganoderma cultivation medium and a preparation method thereof. The lucid ganoderma cultivation medium is prepared from the following raw materials in parts by weight: 20-30 parts of elm branches, 18-28 parts of weed tree sawdust, 8-15 parts of bone meal, 10-15 parts of trichosanthes kirilowii Maxim shell, 5-10 parts of distillers dried grains with soluble, 4-8 parts of worm dung, 8-15 parts of cushaw stem, 5-10 parts of grape seed meal, 4-8 parts of marigold residues, 10-15 parts of bagasse, 0.3-0.6 part of monopotassium phosphate, 0.3-0.6 part of potassium nitrate, 0.3-0.5 part of calcium ammonium nitrate, 1-3 parts of discard molasses, 4-6 parts of plant ash, 1-3 parts of land plaster and 5-10 parts of nutrition additives. According to the cultivation medium disclosed by the invention, raw materials such as cushaw stem and grape seed meal are added on the basis of the traditional sawdust raw materials, cushaw stem and grape seed meal are abundant and are rich in various nutritive elements, and therefore the forest resource pressure is relieved. Meanwhile, the added nutrition additives are good for absorption and growth of lucid ganoderma, the utilization rate of the cultivation medium is improved, the biotransformation rate is increased, and the lucid ganoderma is wide, thick and solid in cover and strong in stem, rich in nutrients and high in medical property.

The invention provides triazole compounds and a preparation method and application thereof. The provided triazole compounds or pharmaceutically acceptable salts thereof have the structure shown as a formula (I), wherein R1, R2 and R3 are respectively and independently selected from -SO2R4, -SO2R5, COR6, H, and halogen; R4, R5 and R6 are respectively and independently selected from an aryl group, a heteroaryl group, a linear or branched alkyl group, an alkenyl group and a cycloalkyl group, wherein the aryl group, the heteroaryl group, the linear or branched alkyl group, the alkenyl group and the cycloalkyl group are unsubstituted or substituted by R7; R7 is selected from halogen, a C1-5 straight or branched alkyl group, a haloalkyl group, a C1-5 straight or branched alkoxy group and a nitro group. The compounds have good inhibitory activity against BRD4, HIV latent virus infection activation activity, low toxicity, high druggability and a more potential clinical application value.

The invention discloses a compound traditional Chinese medicine composition capable of regulating blood fat and a purpose thereof, which belong to the technical field of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following raw materials by weight percentage: 40-80% of a cassia seed extract product, 10-50% of Poria cocos powder, and 5-15% of cucumber-seed powder. The cassia seed extract product is prepared by the process that a cassia seed drying medicinal material is subjected to heating reflux extraction with an ethanol aqueous solution with the volume percentage concentration of 50%, and vacuum concentration. Through pharmacological experiment on experiment hybrid hyperlipidemia rats, the compound traditional Chinese medicine composition has the advantages of obvious fat regulation, good security, simple and convenient medication, low cost, and convenient transport and preservation, and the traditional Chinese medicine composition as a blood fat-adjusting medicine has wide application prospect.

The present invention provides an artemether derivative with high anti-cancer biological activity. The artemether derivative has a chemical structure as shown in the following formula (I): the anti-tumor effect of CT3-1 prepared by the present invention is significantly better than that of the positive In contrast, it has good antitumor activity and strong druggability, and has great development value and clinical application prospect. The present invention also relates to the application and preparation method of the artemether derivative.

The invention relates to the field of health-care lozenge and discloses an anoectochilus formosanus lozenge and a making technology thereof. According to the technical key points, the anoectochilus formosanus lozenge comprises anoectochilus formosanus, red sage root, anemarrhena, gynostemma pentaphylla, dendrobium and an auxiliary agent. The making technology comprises the following steps: selecting fresh anoectochilus formosanus and removing impurities and soil, rinsing with clear water and air-drying, cutting into strips of 3-5 mm long, extracting a crushed anoectochilus formosanus solutionthrough hot water, concentrating until relative density is 1.2-1.3 to obtain an anoectochilus formosanus concentrate, mixing proper amounts of red sage root, anemarrhena, gynostemma pentaphylla and dendrobium by an equivalent incremental method, grinding and filtering through a filter screen to obtain mixed powder, mixing the anoectochilus formosanus concentrate and the mixed powder, mixing stiffpaste and a proper amount of the auxiliary agent so as to prepare the lozenge. Existing anoectochilus formosanus products have simple types and need to be decocted in order to obtain nutrients, the cumbersome decoction mode is hard to adapt to the fast pace of life, and a liquid solvent is not convenient to carry. The above problems are solved in the invention.

The invention discloses a Peganumine A alkaloid structure simplifier, a stereoisomer or a pharmaceutical salt thereof. The structure is shown in the following general formula: each substituent group is defined in the specification. The simplified structure of the Peganumine A alkaloid provided by the invention has a relatively obvious proliferation inhibition effect on liver cancer HepG2, lung cancer A549 and intestinal cancer HCT116, and the anti-tumor activity of part of compounds is higher than the anti-liver cancer HepG2 activity of Peganumine A reported in literatures.

The invention discloses an oligo (ethylene glycol) modified chlorambucil medicine. The structural formula of the short-chain polyethylene glycol modified chlorambucil medicine is shown as a formula I; and in the formula I, the number-average molar mass of oligo (ethylene glycol) (OEG) segments is 198-1,998. The medicine is an amphiphilic anti-cancer medicine, can be self-assembled to form nanoparticles in water or a buffer solution, has long blood circulation time, can target tumors through ultra permeability and enhanced permeation and retention (EPR) effect and can effectively target cancer tissues through the EPR effect of the tumors; and compared with other chlorambucil medicine systems, the chlorambucil medicine has the advantages of high medicine loading rate, high druggability and the like and is expected to be used for clinical treatment of various tumors.

The invention provides heterocyclic compounds represented by a formula (I) as described in the specification or a pharmaceutically acceptable salt thereof, a preparation method thereof, and application of the heterocyclic compounds to the preparation of medicines used for treating or preventing influenza A viruses. The compounds can inhibit the transcription and synthesis of RNAs of influenza viruses and are a PB2 inhibitor.

The invention discloses a biological agent rapid to absorb and a preparation method thereof, which relates to the field of novel medicine. The biological agent is prepared from the following raw materials in parts by weight: 10 to 20 parts of cassia twig, 5 to 8 parts of herba coriandri, 1 to 2 parts of flos inulae helianthus-aquatica, 6 to 9 parts of radix serratulae chinensis, 12 to 15 parts ofcaulis polygoni multiflori, 8 to 10 parts of fructus choerospondiatis, 3 to 5 parts of medicated leaven, 15 to 20 parts of endothelium corneum gigeriae galli, 7 to 10 parts of dried orange peel, 16 to22 parts of herba corydalis saxicolae, 18 to 25 parts of dandelion, 7 to 10 parts of saffron crocus, 10 to 13 parts of rhizoma smilacis glabrae, 8 to 10 parts of herba salviae chinensis, 4 to 6 partsof flos lonicerae, 5 to 8 parts of radix angelicae pubescentis, 2 to 3 parts of radix salviae miltiorrhizae, 2 to 5 parts of rhizoma atractylodis, and 3 to 5 parts of activation aid. The prepared biological agent is fast in effectiveness, small in side effect, and not only capable of reducing the blood pressure, but also capable of supplementing Qi and blood, and increasing the appetite.

The invention discloses use of aloeemodin in preparing of medicament for preventing and treating myocardial ischemia and arrhythmia, and belongs to the technical field of medicines. Pharmacodynamic experiments of the aloeemodin show that the aloeemodin can significantly improve left ventricular ejection fraction and shortening fraction of an animal model of acute myocardial ischemia, and has obvious protective effect against myocardial ischemia; at the same time, the aloeemodin can also reverse heart QT interval prolongation caused by an animal model of hyperlipidemia, and has potential antiarrhythmic effect. The invention discloses the use of the aloeemodin in prevention and treatment of the myocardial ischemia and the arrhythmia, and the aloeemodin has the advantages of obvious myocardial protection effects, low toxicity, low price, and convenient production, transportation, storage and use, and has broad application prospects as a myocardial protection drug.

The invention discloses a series of novel triazole compounds obtained by coupling a triazole drug skeleton and diversified lipophilic cations through different chains, and also discloses a preparationmethod of the compounds and application of the compounds in antifungal aspects. The research found that the triazole drug skeleton is coupled with lipophilic cations, so that the efflux effect of anefflux pump on azole drugs can be overcome, and the drug resistance problem of the azole drugs is solved.

The invention discloses a high-efficiency biological preparation suitable for acute gastroenteritis, and relates to the fields of biology and new medicine. The high-efficiency biological preparation consists of the following raw materials in parts by weight: 10-20 parts of honeysuckle, 5-8 parts of Chinese yam, 1-2 parts of liquorice, 6-9 parts of grain sprout, 12-15 parts of medicated leaven, 8-10 parts of endothelium corneum gigeriae galli, 3-5 parts of cortex cinnamomi, 15-20 parts of agastache rugosus, 16-22 parts of root of meadowrueleaf corydalis, 18-25 parts of dandelion, 7-10 parts ofherba euphorbiae hirtae, 10-13 parts of rhizoma dryopteris crassirhizomae, 8-10 parts of pericarpium citri reticulatae viride, 4-6 parts of herba aristolochiae, 2-5 parts of rhizoma atractylodis and 3-5 parts of an activation auxiliary agent. The activation auxiliary agent is added in the biological preparation formula, the therapeutic activity of other raw materials in the traditional Chinese medicine formula can be stimulated, the treatment cycle is shortened, and the prepared biological preparation has the advantages of quick effect and little side effect, can treat acute gastroenteritis, and can supplement qi and blood, enhance appetite, and prevent appetite loss and sharp weight loss caused by gastroenteritis.

The invention discloses a Peganumine A alkaloid structural simplification, a stereoisomer or a medicinal salt thereof, the structure of which is shown in the following general formula:. The structural simplification of Peganumine A alkaloids provided by the present invention has obvious growth inhibitory effects on liver cancer HepG2, lung cancer A549 and intestinal cancer HCT116, and the antitumor activity of some compounds is stronger than the anti-hepatoma HepG2 activity of Peganumine A reported in the literature. .

The invention discloses a high-clarity biological preparation and application thereof and relates to the field of biology and new medicines. The high-clarity biological preparation consists of the following raw materials in parts by weight: 10-20 parts of golden cypress, 5-8 parts of folium artemisiae argyi, 1-2 parts of radix bupleuri, 6-9 parts of calamus, 12-15 parts of herba houttuyniae, 8-10parts of herba scutellariae barbatae, 3-5 parts of schisandra chinensis, 15-20 parts of chenopodium ambrosioides, 7-10 parts of folium isatidis, 16-22 parts of meadowrueleaf corydalis root, 18-25 parts of dandelion, 7-10 parts of saffron crocus, 10-13 parts of rhizoma smilacis glabrae, 8-10 parts of scutellaria baicalensis, 4-6 parts of honeysuckle, 5-8 parts of sweet wormwood, 2-3 parts of pangolin, 16-20 parts of eleusine indica, 1-2 parts of peganum harmala, 2-5 parts of atractylodes rhizome and 3-5 parts of an activating aid. The biological preparation is quick in effect and small in sideeffect and not only can treat rheumatoid arthritis, but also can supplement Qi and blood and enhance the appetite.

The invention discloses application of an emodin succinyl ester compound in preparation of a medicine for resisting myocardial ischemia and belongs to the technical field of medicines. The emodin succinyl ester compound has a structure shown as a formula I (R is C1 to C5 alkyl). Pharmacological experiments on rats and mice for experimenting myocardial infarction prove that the emodin succinyl ester compound has the advantages of remarkable myocardial ischemia resisting effect, good safety, simplicity and convenience for drug utilization, low raw material price and easiness for obtaining, and convenience for transportation and preservation. The emodin succinyl ester compound disclosed by the invention is used as a myocardial ischemia resisting drug and has a wide application prospect. The formula I is shown in the description.

The invention discloses a compound with an anti-tumor effect and a preparation method and application thereof.The compound is 9-0-ethyl ether berberrubine and has the structure shown in the formula I (n is 1-50), preferably, n is 1, and experiments prove that the 9-0-ethyl ether berberrubine has the advantages that the anti-tumor effect is remarkable, and the anti-tumor effect is good. Compared with berberine, the berberine derivative has the advantages that the berberine derivative has a better effect than berberine, the safety is good, the medication is simple and convenient, the raw materials are low in price and easy to obtain, and transportation and preservation are convenient, the invention further discloses a method for preparing the compound, and the method is simple in route, capable of effectively saving the synthesis time and reducing the cost, simple to operate, easy to implement, suitable for industrial production and suitable for industrial production. The 9-0-ethyl ether berberrubine disclosed by the invention has a wide application prospect as an anti-tumor drug.

The invention provides a crystal structure and application of recombinant apolipoprotein J and analogues thereof. The primary sequence of amino acid is arbitrary one of SEQ ID NO. 1-28. The recombinant apolipoprotein J has a space structure without an artificially added structure, cannot easily induce an immunogenic reaction, has no other toxic or side effect, and has strong druggability; Meanwhile, the purified product has remarkable immunological activity, biological activity and pharmaceutical effect, can be used for effectively treating diseases of tested animals, and has a very good application value.

Belonging to the field of medical technologies, the present invention discloses application of aloe-emodin in preparation of drugs reducing blood lipid and liver lipid. Specifically, blood lipid refers to total cholesterol and low density lipoprotein in serum, and liver lipid refers to total cholesterol in liver. Toxicity tests show that aloe-emodin has no obvious toxic and side effect. Pharmacodynamic tests of aloe-emodin show that aloe-emodin can significantly reduce the total cholesterol and low density lipoprotein in hyperlipidemia animal model serum, and has obvious blood lipid reducing effect. At the same time, aloe-emodin can also significantly reduce the total cholesterol content of a hyperlipidemia animal model liver, and has obvious liver lipid reducing effect. Therefore, the invention puts forward the application of aloe-emodin in reduction of blood lipid and liver lipid, aloe-emodin has the characteristics of significant lipid reducing effect, low toxicity, no irritation, low price, and convenient production, transportation, storage and taking, and can have broad application prospects as a blood lipid and liver lipid reducing drug.

The invention discloses a broad-spectrum anti-inflammatory polypeptide compound with NMDA and p55PIK as targets and a preparation method and application thereof. The broad-spectrum anti-inflammatory polypeptide compound comprises an active peptide fragment, the amino acid sequence of the active peptide fragment is MMTYSTELIFYIEMDP or MMTYSTELIFYIEMDPG, the broad-spectrum anti-inflammatory polypeptide compound further comprises a transmembrane structure or fatty acid loaded at the N-terminal of the active peptide fragment, the fatty acid is capric acid, lauric acid or palmitic acid, the polypeptide compound with the structure is a non-steroidal inhibitor, taking a PI3K subtype member, p55PIK, as a target can effectively inhibit the occurrence of inflammation, the saturated fatty acid is connected to the N-terminal, so as to be able to effectively help an active region to penetrate through a cell membrane, reach a target site and exert effects, bridging polyethylene glycol can enhance polarity to be easy to penetrate through the membrane, and can also increase water solubility to make the druggability strong, and the C-terminal structure can increase the stability of the preparation, so as to achieve good druggability.

The present invention provides a class of heterocyclic compounds represented by formula (I) or pharmaceutically acceptable salts thereof, their preparation methods and their application in the preparation of medicines for treating or preventing influenza virus. As novel viral polymerase inhibitors, these compounds can inhibit the transcription and synthesis of type A influenza virus RNA. Compared with existing viral polymerase inhibitors, the compounds of the present invention have significantly better activity and better water solubility And the structure is simpler.

The invention relates to the field of health-care potions, in particular to herba anoectochili formosani oral liquid and a preparation process. The oral liquid is characterized by being prepared fromherba anoectochili formosani, cortex moutan, rhizoma corydalis, radix notoginseng and fructus schisandrae; the preparation process comprises the following steps: selecting fresh herba anoectochili formosani, removing sundries and clay, drying in air after rinsing and then feeding into a crusher for carrying out crushing treatment; carrying out digestion with hot water on the crushed herba anoectochili formosani solution to obtain a herba anoectochili formosani concentrate; mixing proper amounts of the cortex moutan, the rhizoma corydalis, the radix notoginseng and the fructus schisandrae and then putting a mixture into a pulverizer for smashing; filtering by using screen cloth to obtain mixed powder; mixing the herba anoectochili formosani concentrate with the mixed powder and carrying outwater-bath heating, standing and then filtering with a filtering screen to obtain crude oral liquid; carrying out anti-corrosion and sterilization treatment on the oral liquid, thus obtaining the herba anoectochili formosani oral liquid. The extraction process disclosed by the invention has the advantages that the cost is low, economic benefits are obviously improved and effective components of aproduct are enabled not to be destroyed, so that the promotion of a herba anoectochili formosani product is facilitated.

The invention relates to a method for planting high-yield rhizoma polygonati. The method comprises the following planting steps: first step: reclamation: wetting soil at first without generating accumulated water, loosening the soil, enabling the distance between two adjacent tubers to be 20 cm during planting, and therefore spreading quick lime according to the distance before planting for disinfection; second step: fertilizing; third step, tuber planting: sterilizing tubers by using rooting powder and mycostatin, then dividing each tuber into 2-3 sections, burying and then covering the tubers with soil; fourth step, fertilizing once separately in spring and autumn; fifth step: weeding and soil loosening; and sixth step: sprouting, wherein the tubes with bud heads sprout in spring, tubeswithout bud heads sprout in autumn, the sprouting rate is 95% or above, seedlings have lots of buds, the buds in the year are multiple times more than the buds in previous year, and the rhizoma polygonati bears fruits in the second year. The planted rhizoma polygonati is high in yield and high in medicinal property, and can grow all the year round.