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Use of aloe-emodin in the preparation of drugs for the prevention and treatment of myocardial ischemia and arrhythmia

A technology of aloe-emodin and myocardial ischemia, which is applied in the field of medicine to achieve the effects of being easy to accept, reducing the size of myocardial infarction, and having strong druggability

Active Publication Date: 2020-05-26
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the effect of aloe-emodin on the prevention and treatment of myocardial ischemia and arrhythmia at home and abroad.

Method used

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  • Use of aloe-emodin in the preparation of drugs for the prevention and treatment of myocardial ischemia and arrhythmia
  • Use of aloe-emodin in the preparation of drugs for the prevention and treatment of myocardial ischemia and arrhythmia
  • Use of aloe-emodin in the preparation of drugs for the prevention and treatment of myocardial ischemia and arrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Pharmacodynamic study of aloe-emodin anti-acute myocardial ischemia

[0031] 1 Experimental method:

[0032] 24 male Kunming mice were randomly divided into four groups: normal control group, myocardial ischemia group, aloe-emodin pretreatment group (myocardial infarction+100mg aloe-emodin / kg mouse body weight), aloe-emodin alone group (100mg aloe-emodin Emodin / kg mouse body weight), 6 mice in each group. In the myocardial ischemia group, the left anterior descending coronary artery was ligated to establish a myocardial ischemia model. After 3 days, the heart function was detected, and the myocardial infarct size was measured. In the aloe-emodin group, 100 mg aloe-emodin / kg mouse weight was administered orally to the mice for 2 consecutive weeks, and then the left anterior descending coronary artery was ligated to establish a myocardial ischemia model. During the ischemia period, the intragastric administration was continued, and the cardiac function was dete...

Embodiment 2

[0035] Example 2 Pharmacodynamic study of aloe-emodin against arrhythmia

[0036] 1 Experimental method:

[0037] Rat models of hyperlipidemia were established by feeding with high-fat diet. Among them, except that the control group was fed with ordinary feed at 20 g / bird / day, the rest of the groups were fed with high-fat feed at 20 g / bird / day and had free access to water. The rats were fed continuously for 4 weeks to establish a hyperlipidemia model. After the model was successfully established, aloe-emodin (100 mg / kg) or atorvastatin (7.2 mg / kg) was administered by intragastric administration, and the control group and the high-fat model group were treated with pure water intragastric administration once a day. The volume of each administration was calculated according to the weight of the rats at 1 mL / 100 g, and the administration was administered for 6 weeks. During the administration period, the control group was still fed with common feed, and the other groups were stil...

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Abstract

The invention discloses use of aloeemodin in preparing of medicament for preventing and treating myocardial ischemia and arrhythmia, and belongs to the technical field of medicines. Pharmacodynamic experiments of the aloeemodin show that the aloeemodin can significantly improve left ventricular ejection fraction and shortening fraction of an animal model of acute myocardial ischemia, and has obvious protective effect against myocardial ischemia; at the same time, the aloeemodin can also reverse heart QT interval prolongation caused by an animal model of hyperlipidemia, and has potential antiarrhythmic effect. The invention discloses the use of the aloeemodin in prevention and treatment of the myocardial ischemia and the arrhythmia, and the aloeemodin has the advantages of obvious myocardial protection effects, low toxicity, low price, and convenient production, transportation, storage and use, and has broad application prospects as a myocardial protection drug.

Description

technical field [0001] The invention relates to a new application of aloe-emodin, in particular to the application of aloe-emodin in the preparation of drugs for treating myocardial ischemia and arrhythmia, and belongs to the technical field of medicine. Background technique [0002] In recent years, the morbidity and mortality of cardiovascular diseases have remained high. Every year, the number of patients who die of cardiovascular diseases in the world is as high as 15 million, ranking first among various causes of death and seriously threatening human health. Although the current clinical treatment measures such as drug therapy, medical interventional therapy and surgical operation can relieve the symptoms of cardiovascular diseases to a certain extent, the morbidity and mortality of cardiovascular diseases have not been significantly improved. It is of great scientific significance and clinical application value to propose new treatment strategies accordingly. [0003]...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/122A61P9/06A61P9/10
CPCA61K31/122
Inventor 杜智敏
Owner HARBIN MEDICAL UNIVERSITY
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