Use of emodin succinyl ester compounds in the preparation of anti-myocardial ischemia drugs
A technology of emodin succinyl ester and emodin succinyl ethyl ester, which is applied in the field of medicine, can solve problems such as unsatisfactory treatment effect, and achieves reduction of ischemic myocardial infarction area, prevention and treatment of myocardial ischemia, and anti-myocardial ischemia. The effect of blood protection
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Embodiment 1
[0051] The preparation of embodiment 1 emodin ethyl succinate
[0052] Take succinic anhydride (1.0g, 10mmol) and place it in a 10mL round-bottomed flask, use ethanol (3.5mL, 60mmol) as a solvent, heat and reflux for 4 hours, and distill off excess ethanol under reduced pressure to obtain a light yellow oil, namely succinic acid mono Ethyl ester (1.4 g, 96%), this product was carried on to the next reaction without isolation.
[0053] Get monoethyl succinate (1.0g, 6.8mmol) and place in a 10mL round-bottomed flask, use thionyl chloride (4.0g, 34.0mmol) as solvent, heat to reflux for 2 hours, and remove excess oxychloride by distillation under reduced pressure. The sulfone was obtained as a light yellow oily product, namely ethyl succinic acid chloride (1.1 g, 98%), and the product was directly carried on to the next reaction without separation.
[0054] Take emodin (1.0g, 3.7mmol) and pyridine (0.45g, 5.6mmol) in a 10mL round-bottomed flask, use dichloromethane (3mL) as solve...
Embodiment 2
[0058] The preparation of embodiment 2 emodin ethyl succinate
[0059] Take succinic anhydride (10g, 100mmol) and place it in a 150mL round-bottomed flask, use ethanol (40mL, 600mmol) as a solvent, heat and reflux for 6 hours, and distill off excess ethanol under reduced pressure to obtain a light yellow oil that is monoethyl succinate (14 g, 96%), the product was directly carried on to the next reaction without isolation.
[0060] Get monoethyl succinate (10g, 68mmol) and place in a 150mL round-bottomed flask, use thionyl chloride (40g, 340mmol) as a solvent, heat and reflux for 2 hours, and remove excess thionyl chloride by distillation under reduced pressure to obtain light The yellow oil was succinic acid monoethyl chloride (11 g, 98%), and the product was directly carried on to the next reaction without isolation.
[0061] Get emodin (10g, 37mmol) and triethylamine (2.3g, 22mmol) and place in a 250mL round-bottomed flask, use dichloromethane (3mL) as solvent, slowly drop...
Embodiment 3
[0064] The preparation of embodiment 3 emodin ethyl succinate
[0065] Take succinic anhydride (10g, 100mmol) and place it in a 150mL round-bottomed flask, use ethanol (20mL, 434mmol) as a solvent, heat and reflux for 2 hours, and distill off excess ethanol under reduced pressure to obtain a light yellow oil that is monoethyl succinate (14 g, 96%), the product was directly carried on to the next reaction without isolation.
[0066] Get monoethyl succinate (10g, 68mmol) and place in a 150mL round-bottomed flask, use thionyl chloride (20g, 170mmol) as a solvent, heat and reflux for 1 hour, and remove excess thionyl chloride by distillation under reduced pressure to obtain light The yellow oil was succinic acid monoethyl chloride (8 g, 98%), and the product was directly carried on to the next reaction without isolation.
[0067] Take emodin (10g, 37mmol) and ammonia water (1.5g, 44mmol) and place in a 250mL round-bottomed flask, use dichloromethane (3mL) as solvent, slowly add s...
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