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A bone wound hemostatic composition and its preparation method and application

A composition and wound surface technology applied in the field of bone hemostasis to achieve high safety, improved hemostatic effect, and good hemostatic effect

Active Publication Date: 2020-05-01
SAIKE SAISI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

From the understanding of the above existing technologies, there is no good bone hemostatic material that can satisfy the ideal, and further research and improvement are needed.

Method used

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  • A bone wound hemostatic composition and its preparation method and application
  • A bone wound hemostatic composition and its preparation method and application
  • A bone wound hemostatic composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The formula of the bone wound hemostatic composition of the present invention is shown in Table 1 below:

[0039] Table 1. Embodiment 1 formula table

[0040]

[0041] The preparation method of the bone wound hemostatic composition is as follows:

[0042] 1. Weigh glycerol and medical-grade high-viscosity carboxymethylcellulose sodium according to the formula table, and obtain a uniform solution under stirring conditions. The solution was heated up slowly, and stirred at 30°C for 30 minutes to make the homogeneous solution into a viscous solvent matrix, which was swollen overnight.

[0043] 2. Weigh the sodium carboxymethyl starch according to the formula table, slowly add it into the viscous solvent matrix that is completely swollen, stir vigorously while adding it, until a uniform paste is formed, about 2 hours;

[0044] 3. Weigh calcium sulfate according to the formula table, slowly add it to the above paste, and continue to stir until a uniform paste is formed,...

Embodiment 2

[0047] The formula of the bone wound hemostatic composition of the present invention is shown in Table 2 below:

[0048] Table 2. Embodiment 2 formula table

[0049]

[0050] The preparation method of the bone wound hemostatic composition is as follows:

[0051] 1. Weigh glycerol, polyethylene glycol-400, hydroxypropyl methylcellulose with a nominal viscosity of 50-1500cps and hydroxyethylcellulose with a nominal viscosity of 1500-2500cps according to the formula table, stirring conditions A homogeneous solution was obtained. The solution was heated up slowly, and stirred at 75°C for 30 minutes to make the homogeneous solution into a viscous solvent matrix, which was swollen overnight.

[0052] 2. Put the obtained viscous solvent matrix into the kneader, start the kneader to stir, weigh the sodium alginate and dextrin according to the formula table, mix the two, and then slowly add them to the kneader while adding Knead while kneading until a uniform paste is formed, abo...

Embodiment 3

[0056] The formula of the bone wound hemostatic composition of the present invention is shown in Table 3 below:

[0057] Table 3. Embodiment 3 formula table

[0058]

[0059]

[0060] The preparation method of the bone wound hemostatic composition is as follows:

[0061] 1. Weigh propylene glycol, polyethylene glycol-300, medical grade carrageenan, hydroxyethyl cellulose with a nominal viscosity of 250-400cps and hydroxypropyl methylcellulose with a nominal viscosity of 4000-9000cps according to the formula table , a homogeneous solution obtained under stirring conditions. The solution was heated up slowly, and stirred at 50°C for 30 minutes to make the homogeneous solution into a viscous solvent matrix, which was swollen overnight.

[0062] 2. Put the obtained viscous solvent matrix into the kneader, start the kneader to stir, weigh the potato starch and sodium carboxymethyl starch according to the formula table, mix the two, and then slowly add them to the kneader, ...

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Abstract

The invention discloses a bone wound hemostasis composition as well as a preparation method and application thereof. The bone wound hemostasis composition is prepared from a solvent matrix, a thickener, an excipient and ionic salt, wherein the solvent matrix is polyhydric alcohol; and the ionic salt is one or more of inorganic calcium salt and inorganic iron salt. The bone wound hemostasis composition is high in bone stickiness and high in plasticity; a slit and a blood sinus on a bone wound can be mechanically filled with the bone wound hemostasis composition, and the bone wound hemostasis composition can further accelerate a natural blood coagulation process and is good in hemostasis effect; the bone wound hemostasis composition is easily degraded in a human body or an animal body, can be absorbed and metabolized, is high in biocompatibility, non-irritating to organs, free of toxic or side effects and high in safety, cannot affect healing of the wound, is convenient for clinical use, and has an extremely good application prospect in the aspect of hemostasis of the bone wound of a human or an animal.

Description

technical field [0001] The invention relates to a bone wound hemostatic composition and its preparation method and application, in particular to a bone wound hemostatic composition with strong plasticity, good adhesion, absorbability and no influence on wound healing, its preparation method and application, belonging to Bone hemostasis technical field. Background technique [0002] Clinically, the structure of cancellous bone is loose and the blood supply is rich, and the wound bleeding is mostly oozing blood. The bleeding in the cancellous bone wound is not continuous or it is difficult to completely stop the bleeding. Vasoconstriction is poor, platelets aggregate, and blood clots are difficult to adhere to bone wounds. Bone wound bleeding is difficult to stop bleeding by vasoconstriction, and it is also difficult to stop bleeding by conventional methods such as electrocoagulation, forceps, hemostatic gauze, and gelatin sponge packing during surgery. Bone wax is commonly ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/00A61L24/08A61L24/04A61L24/06
CPCA61L24/001A61L24/0015A61L24/0042A61L24/046A61L24/06A61L24/08A61L2300/102A61L2300/404A61L2300/406A61L2300/412A61L2300/418C08L1/286C08L3/08C08L71/02C08L1/284C08L5/04C08L3/02C08L33/00C08L5/00
Inventor 任芳李波王月月张林林刘长凤张春霞赵成如
Owner SAIKE SAISI BIOTECH CO LTD
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