Dencichine extraction method and application thereof and extraction method of pseudo-ginseng amino acid

An extraction method and technology of Panax notoginseng, applied in the field of medicine, can solve problems such as irritation of the respiratory system and skin, drowsiness, dizziness, nausea, etc., and achieve the effects of low cost, good hemostatic effect and energy saving.

Active Publication Date: 2017-09-15
云南多糖生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] In the above prior art, n-butanol is used for extraction, and n-butanol has a special smell, which makes people feel sick; steam may cause drowsiness and dizziness; stimulate the respiratory system and skin; and in the prior art, industrial notoginseng waste residues are not It has not been fully utilized, but after removing saponins from 95% ethanol in Panax notoginseng, the waste residue is used to extract notoginseng therein, and the method process of extracting saponins from Panax notoginseng in industry is different from the above documents, and the produced three notoginseng The seven waste residues are also different, and the above methods cannot guarantee that notoginseng can be obtained from industrial notoginseng waste residues.

Method used

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  • Dencichine extraction method and application thereof and extraction method of pseudo-ginseng amino acid
  • Dencichine extraction method and application thereof and extraction method of pseudo-ginseng amino acid
  • Dencichine extraction method and application thereof and extraction method of pseudo-ginseng amino acid

Examples

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Embodiment 1

[0109] A method for extracting notoginseng, comprising the following steps:

[0110] 1. Extraction of Panax notoginseng

[0111] Take 1 kg of industrial notoginseng waste residue, add 6-10 times the volume of distilled water to extract in a constant temperature water bath at 50-80°C for 8 hours, collect the filtrate (coarse filtration with gauze, then separate with a centrifuge, 4500r / min, centrifuge for 10min, pour supernatant), add 3-5 times the volume of distilled water to the filter residue and extract in a constant temperature water bath at 50-80°C for 8 hours, collect the filtrate, and combine the two filtrates. Centrifuge at 4500r / min for 5min, pour off the supernatant, put the supernatant in a rotary evaporator, rotate at 40r / min, concentrate at 50-80°C to 1 / 5 of the original volume, add 3 times the amount of absolute ethanol, Stand at 4°C for 24 hours, then suction filter (use chemical analysis filter paper, vacuum degree: 0.06-0.08MPa); place the filtrate in a rotar...

Embodiment 21

[0122] A method for extracting notoginseng. The difference from Example 1 is that the first and second water extractions are carried out at 60°C.

Embodiment 22

[0124] A method for extracting notoginseng. The difference from Example 1 is that the first and second water extractions are carried out at 70°C.

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Abstract

The invention provides a dencichine extraction method, which takes industrial pseudo-ginseng waste residue as a raw material to extract dencichine. During an extraction process, a thin layer detection method is employed for verifying the product containing the dencichine, subsequent processes such as purifying and crystallization are carried out continuously, after purifying, thin-layer detection is carried out, the eluates having only one spot and having a same Rf value with a dencichine reference substance are merged, and crystallization is carried out. The invention also provides a pseudo-ginseng amino acid extraction method, which takes industrial pseudo-ginseng waste residue as the raw material. The process of the method is substantially same with the above dencichine extraction method, the difference is characterized in that while crystallization is carried out, the merged eluate and the dencichine reference substance have the same spot and other spots. The invention further provides an application of the obtained dencichine, the dencichine can be used for the product having haemostasis function such as toothpaste and adhesive bandage. According to the invention, the industrial pseudo-ginseng waste residue is fully used, waste is changed into valuables, resource re-utilization is realized, and the resource waste is effectively reduced.

Description

technical field [0001] The invention belongs to the technical field of medicines. Specifically, the invention relates to a method for extracting notoginseng from the waste residue of notoginseng, and also relates to the application of the notoginseng extracted from the waste residue of notoginseng. Background technique [0002] Panax notoginseng (Burk.) F.H.Chen] is a precious medicinal material in my country. It has the effects of dissipating blood stasis and stopping bleeding, reducing swelling and relieving pain. The authentic place is Wenshan, Yunnan. The active ingredients of Panax notoginseng include saponins, notoginseng, flavonoids, polyacetylenic alcohols, polysaccharides, fatty acids, and cyclic peptides. At present, the research and utilization of the active ingredients of Panax notoginseng mainly focus on the saponins. The annual planting area of ​​Panax notoginseng in Wenshan, Yunnan, the main producing area of ​​Panax notoginseng, has reached about 120,000 m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/24C07C233/56A61K36/258A61K31/198A61P7/04A61P3/02A61K8/44A61Q11/00
CPCA61K8/442A61K31/198A61K31/44A61K36/258A61Q11/00C07C231/24C07C233/56A61K2300/00
Inventor 陈彤杨晓涵李双
Owner 云南多糖生物科技有限公司
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