A kind of multi-substituted 2-hydroxyl-1,4-benzoxazine derivative

A benzoxazine and multi-substitution technology, applied in the field of multi-substituted 2-hydroxyl-1, can solve the problems of many steps and low yield, and achieve the effects of mild reaction conditions, short reaction time and convenient post-treatment
CN107382899BActive Publication Date: 2021-11-30HUAQIAO UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HUAQIAO UNIVERSITY
Publication Date
2021-11-30

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Abstract

The invention discloses a multi-substituted 2-hydroxyl-1,4-benzoxazine derivative, the structural formula of which is as follows: the present invention synthesizes a multi-substituted 2-hydroxyl-1,4-benzoxazine derivative which cannot be synthesized by other methods. Oxazine derivatives have far-reaching significance from the perspectives of organic synthesis and medicinal chemistry, and the raw materials used in the method of the present invention are easy to get, the yield is high, the reaction conditions are mild, the reaction time is short, the substrate range is wide, and the reaction is specific. Strong, easy to post-treatment and green.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, in particular to a multi-substituted 2-hydroxyl-1,4-benzoxazine derivative. Background technique

[0002] 2-Hydroxy-1,4-benzoxazine derivatives are a class of molecules with various biological activities. They have good insecticidal, bactericidal and anti-inflammatory activities, and have important application values ​​in medicine and pesticides. Therefore, the research on new synthetic methods of 2-hydroxy-1,4-benzoxazine compounds and their analogues has important application value and has attracted the attention of researchers in related fields.

[0003] The traditional synthetic method of 2-hydroxyl-1,4-benzoxazine derivatives is mainly based on substituted o-aminophenol or halogenated arene derivatives as raw materials, and different 1,2-dihaloalkanes, α-substituted halogenated Acid or ester reaction, but the method has many steps and the yield is not high. Based on the extensive...

Claims

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