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Desflurane-based tranquilizer

A sedative and tranquilizing and desflurane technology, applied in the field of medicine, can solve the problems of sudden death, inapplicability, prolonging the time of apnea, etc., and achieve the effects of fast subsidence, fast hypnosis, and pain avoidance

Inactive Publication Date: 2017-12-15
SICHUAN CANCER HOSPITAL
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, insomnia and anxiety are usually relieved by oral stable drugs on the market, but stable drugs have a time lag, which will cause drowsiness, fatigue, listlessness, etc. during the day; For insomniacs with apnea, because sleeping pills can prolong the time of apnea, sudden death may occur; at the same time, some patients are not suitable for taking oral tranquilizers or injecting tranquilizers; and the biotransformation rate of oral tranquilizers is relatively high. Not for use in patients with liver or kidney disease or those undergoing cardiac surgery

Method used

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  • Desflurane-based tranquilizer
  • Desflurane-based tranquilizer
  • Desflurane-based tranquilizer

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Embodiment Construction

[0024] The present invention will be further described in detail below in conjunction with test examples and specific embodiments.

[0025] Desflurane, chemical name: 1,2,2,2-tetrafluoroethyl difluoromethyl ether.

[0026] Structural formula:

[0027]

[0028] Molecular formula: C3H2F6O

[0029] Molecular weight: 168.04

[0030] Physical and chemical properties: Halogenated inhalational general anesthetic, colorless and transparent; under standard atmospheric pressure, the boiling point is 22.8°C, and the saturated vapor pressure at 22°C is 663.75mmHg; the physical, chemical and biological properties are stable. Combustion, no explosion; blood / gas partition coefficient is 0.42, fat / blood partition coefficient is 27.

[0031] Pharmacological characteristics: The blood / air partition coefficient of desflurane is 0.42, which is the smallest among the existing inhalational anesthetics, and the induction and recovery of anesthesia are very rapid. Desflurane has a significant ...

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Abstract

The invention relates to a desflurane-based tranquilizer which comprises a drug and a drug carrier, wherein the drug is desflurane; the drug carrier contains a water-absorbing material and a shell; the water-absorbing material is used for bearing desflurane; the shell is used for cladding the water-absorbing material and avoiding volatilization of the desflurane; an opening is formed in the shell and is used for volatilizing the desflurane from the opening in the treatment process; and a sealing device is arranged on the opening. The desflurane-based tranquilizer provided by the invention is an inhaled drug accepted in a breathing pattern and is high in calming and tranquilizing speed and small in side effects; and moreover, the drug efficacy is quickly eliminated, and normal life and work of a drug user are not influenced. In addition, the desflurane-based tranquilizer is extremely low in biotransformation efficiency, is extremely low or zero in liver and kidney toxicity and is applicable to patients suffering from liver and kidney diseases. Moreover, the desflurane-based tranquilizer has extremely small influence on hemodynamic force and heart rate and is applicable to a patient undergoing cardiac surgery.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a desflurane-based sedative and tranquilizer. Background technique [0002] With the gradual acceleration of the pace of life, the number of people who are often troubled by insomnia and anxiety is gradually increasing. At present, insomnia and anxiety are usually relieved by oral stable drugs on the market, but stable drugs have a time lag, which will cause drowsiness, fatigue, listlessness, etc. during the day; For insomniacs with apnea, because sleeping pills can prolong the time of apnea, sudden death may occur; at the same time, some patients are not suitable for taking oral tranquilizers or injecting tranquilizers; and the biotransformation rate of oral tranquilizers is relatively high. Not for use in patients with liver or kidney disease or those undergoing cardiac surgery. Contents of the invention [0003] The object of the present invention is to provide a desflurane-based s...

Claims

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Application Information

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IPC IPC(8): A61K31/08A61K9/72A61P25/20
CPCA61K31/08A61K9/0043
Inventor 唐育民王朝集刘寅段红杜艺
Owner SICHUAN CANCER HOSPITAL
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