Traditional Chinese medicine for treating gouty arthritis and preparation method thereof

A technology of gouty arthritis and traditional Chinese medicine is applied in the field of medicines and preparations for treating arthritis, which can solve the problems of liver and bone marrow toxicity, renal function damage, large toxic and side effects, etc. Effects of swollen joints

Active Publication Date: 2020-07-24
DALIAN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Allopurinol, the only drug currently on the market that inhibits uric acid production, is suitable for excessive uric acid production, but has adverse reactions such as liver and bone marrow toxicity and allergic reactions
Probenecid, sulfazone, benzbromarone and other uricosuric drugs mainly promote the excretion of uric acid by inhibiting the reabsorption of uric acid in the proximal renal tubules. The biggest disadvantage is that it can cause the deposition of urate crystals in the urinary tract. Cause renal colic and renal impairment
To sum up, Western medicine used to treat gouty arthritis drugs and biological agents are often difficult to promote or long-term use due to unsatisfactory curative effect, or serious side effects

Method used

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  • Traditional Chinese medicine for treating gouty arthritis and preparation method thereof
  • Traditional Chinese medicine for treating gouty arthritis and preparation method thereof
  • Traditional Chinese medicine for treating gouty arthritis and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0011] a. Mix 10g Cortex Phellodendri, 10g Atractylodes Rhizoma Atractylodis, 30g Smilax Smilax, 10g Licorice, 15g Clematis, 10g Radix Paeoniae Rubra, 15g Polygonum cuspidatum, 10g Angelica sinensis, 8g Shanzigu, 10g Duhuo, 15g Codonopsis pilosula, 10g wine rhubarb, mix and crush, Place in a round bottom flask, add 8 times the amount of pure water of the total raw materials, shake and mix, and soak for 30 minutes;

[0012] b. Connect the round-bottomed flask to the volatile oil extractor and the reflux condenser, add water from the upper end of the condenser until it fills the scale part of the volatile oil detector and overflows into the round-bottomed flask, then place the round-bottomed flask in an electric heating mantle and heat it slowly to Boil the water and keep the water slightly boiled for 6 hours, stop heating, let it cool down, open the lower piston of the volatile oil extractor, slowly release the water, collect the volatile oil, and set aside;

[0013] c. Take th...

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Abstract

The invention discloses a traditional Chinese medicine for treating gouty arthritis. The traditional Chinese medicine is composed of Chinese herbal medicine volatile oil and aqueous extract, wherein the Chinese herbal medicine comprises the following components in parts by weight: 10 parts of golden cypress, 10 parts of rhizoma atractylodis, 30 parts of rhizoma smilacis glabrae, 10 parts of liquorice, 15 parts of radix clematidis, 10 parts of common peony root, 15 parts of polygonum cuspidatum, 10 parts of angelica sinensis, 8 parts of edible tulip, 10 parts of radix angelicae pubescentis, 15 parts of codonopsis pilosula and 10 parts of wine-treated rhubarb. A pharmacological experiment result proves that the traditional Chinese medicine has an excellent function of treating gouty arthritis, has the effects of improving arthrocele, inflammatory factor change, antioxidant factor change, and the like, caused by gouty arthritis, can be prepared into drugs in various dosage forms together with a pharmaceutically acceptable carrier and can be conveniently clinically taken. A preparation method provided by the invention is high in operability, low in cost, environment-friendly and capable of realizing industrial large-scale production.

Description

technical field [0001] The invention provides a medicine for treating arthritis and a preparation method thereof, in particular a traditional Chinese medicine for treating gouty arthritis with reliable curative effect and little side effects and a preparation method thereof. Background technique [0002] Gouty arthritis is a disease mainly caused by joint pain, swelling and deformity caused by purine metabolism disorder, excessive uric acid production or excretion disorder, which leads to increased blood uric acid concentration and urate deposition. It has the characteristics of rapid onset, severe pain, protracted and difficult to heal, etc., which makes people miserable and has seriously affected people's health and daily life. Colchicine is one of the effective drugs for the treatment of gout, especially severe acute attacks, but colchicine can neither inhibit the production of uric acid nor promote the excretion of uric acid. Diarrhea, vomiting, and abdominal cramps are...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/90A61K36/898A61P29/00A61P19/02A61P19/06
CPCA61K36/232A61K36/284A61K36/344A61K36/484A61K36/65A61K36/704A61K36/708A61K36/71A61K36/716A61K36/756A61K36/896A61K36/898A61K36/90A61K2236/15A61K2236/331A61K2236/39A61K2300/00
Inventor 张琳李炜玲隋华肖楠何世勇
Owner DALIAN MEDICAL UNIVERSITY
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