Lubiprostone refining method
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BEIJING SHENLANHAI BIO PHARM TECH
- Publication Date
- 2017-12-15
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention provides a method for refining Lubiprostone. In the method, the crude lubiprostone is recrystallized in an organic solvent and crystallized at 20-30° C., so that the lubiprostone with a purity of not less than 99.0% can be obtained in a high yield. Background technique
[0002] Lubiprostone, chemical name (2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5 ,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid, the chemical structure of which is:
[0003] .
[0004] Lubiprostone is the active pharmaceutical ingredient of the drug Amitiza® developed by Sucamp Company of the United States. Lubiprostone belongs to a chloride ion channel activator, which can specifically act on the type II chloride ion channel on the epidermal cell membrane of the gastrointestinal tract, stimulate the secretion of intestinal fluid with high chloride ion concentration, increase intestinal motility, and promote Softened stool passes through the bo...