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Method for detecting secondary alkaloids produced through nicotine degradation by simulating actual environment

A technology of actual environment and detection method, applied in the field of physical and chemical identification and inspection of tobacco products, to achieve the effect of convenient and easy degradation experiment, scientific and effective degradation scheme, and simple and fast detection method

Active Publication Date: 2017-12-29
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nicotine has the potential to degrade during actual storage, converting to different types of minor alkaloids

Method used

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  • Method for detecting secondary alkaloids produced through nicotine degradation by simulating actual environment
  • Method for detecting secondary alkaloids produced through nicotine degradation by simulating actual environment
  • Method for detecting secondary alkaloids produced through nicotine degradation by simulating actual environment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In this example, an imported nicotine is used to extract nicotine, and it is tested for oxidative degradation in the dark, and the results are analyzed:

[0031] 1. Reagents and instruments

[0032] Standard products: nicotine, N-methylbasine, nornicotine, mesmin, pseudobasine, β-diene nicotine, anatabine, 2,3'-bipyridine, β-diene Nornicotine, cotinine, hal base, Yantailin;

[0033] Internal standard: quinoline, (±)-nornicotine-2,4,5,6-d4 and 2,2’-bipyridine-d8;

[0034] Reagent: dichloromethane;

[0035] Container: 2ml light-proof glass bottle with PTFE septum screw cap, 10ml light-proof volumetric flask;

[0036] Instrument: Gas Chromatography Mass Spectrometer (Agilent Corporation), AE163 Electronic Balance, Sensitivity: 0.0001g (Switzerland Mettler Company), THS500 Stability Test Chamber (as the used light-proof test chamber of the present invention);

[0037] 2. Sample degradation:

[0038] Take 1ml of nicotine and put it into a light-proof bottle, put the ope...

example 2

[0045] To compare and investigate the degradation and transformation of nicotine under the condition of closed degradation of a certain synthetic nicotine by light. The nicotine degradation condition adopts Scheme 1, and the detection method is the same as Example 1, and the measurement results are shown in Table 2 below.

[0046] .

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Abstract

The invention provides a method for detecting secondary alkaloids produced through nicotine degradation by simulating an actual environment. The method comprises steps as follows: simple sample preparation, determination of an actual environment condition simulation scheme, sampling at multiple points in time, quantitative analysis with gas chromatography-mass spectrometry, data analysis of a measured result and the like. A degradation scheme comprises two major variables, simulation of the real environmental conditions and chemical stability property of nicotine are taken into consideration comprehensively, the operation is simple, and feasibility and scientificity of the scheme are high. The detection method has the advantages of short detection time, high sensitivity and the like. With the application of the technical scheme, the nature of transformation of multi-source nicotine into secondary alkaloids can be taken into consideration comprehensively, a reliable nicotine and secondary alkaloid transformation map is obtained, and scientific support is provided for a tobacco product identification method with the secondary alkaloids as indexes in the tobacco industry.

Description

technical field [0001] The invention designs a detection method for secondary alkaloids produced by nicotine degradation in a simulated actual environment, and belongs to the technical field of physical and chemical identification and inspection of tobacco products. Background technique [0002] In recent years, tobacco products have shown a trend of diversified development, especially the emergence of new tobacco products, which has brought new challenges to the regulation of tobacco products in my country. The diversity of forms and appearances of tobacco products requires us to master comprehensive and systematic identification indicators of tobacco characteristics, so as to realize the accurate identification and judgment of different types of tobacco products in my country's tobacco industry. [0003] Nicotine is the most important pharmacological component of tobacco and one of the most important reasons why people consume tobacco. In addition to tobacco, there are ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李翔宇韩书磊庞永强姜兴益张洪非胡少东朱风鹏罗彦波陈欢刘彤付亚宁夏友明
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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