Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, application of pharmaceutical composition and injection prepared from pharmaceutical composition

A technology for cardiovascular and cerebrovascular diseases and compositions, applied in the field of pharmaceutical compositions and their applications and injections prepared from them, can solve the problem that ginkgo biloba extract and its preparations are difficult to meet quality requirements, cannot guarantee drug safety, and active ingredients Unclear and other problems, to achieve the effect of low price, clear components, and easy access

Inactive Publication Date: 2018-01-09
朗致集团江西医药有限公司
View PDF3 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, the technical problem to be solved by the present invention is to overcome the defect that the Ginkgo biloba extract and its preparations prepared by the prior art are difficult to meet the quality requirements and cannot guarantee the safety of medication, and the unclear active ingredients lead to indefinite curative effect, and then provide a New pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and its application and injection prepared therefrom

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, application of pharmaceutical composition and injection prepared from pharmaceutical composition
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, application of pharmaceutical composition and injection prepared from pharmaceutical composition
  • Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, application of pharmaceutical composition and injection prepared from pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The invention provides a method for preparing an injection containing a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, comprising the following steps:

[0040] (1) After getting Ginkgo biloba pulverization, add 95% ethanol and reflux extraction 3 times, each reflux extraction time is 0.5 hour, the quality that adds 95% ethanol at every turn is 10 times of Ginkgo leaf quality; Filter, gained filtrate decompression Concentrate to 0.2 times of the quality of the ginkgo leaves, and refrigerate for 48 hours;

[0041] (2) Scrape off the slick oil and take off the lower layer liquid;

[0042] (3) Add water for injection to 0.5 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 48 hours; filter, concentrate the filtrate under reduced pressure to 0.2 times of the quality of ginkgo leaves, put to room temperature, add 95% ethanol, make the alcohol content to 80%, the solution after alcohol precipitation was ...

Embodiment 2

[0047] The invention provides a method for preparing an injection containing a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, comprising the following steps:

[0048] (1) After getting Ginkgo biloba pulverization, add 90% ethanol and reflux extraction 4 times, each reflux extraction time is 0.6 hour, the quality that adds 90% ethanol at every turn is 11 times of Ginkgo biloba quality; Filter, gained filtrate is decompressed Concentrate to 0.15 times of the quality of the ginkgo leaves, and refrigerate for 45 hours;

[0049] (2) Scrape off the slick oil and take off the lower layer liquid;

[0050] (3) Add water for injection to 0.6 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 51 hours; filter, concentrate the filtrate under reduced pressure to 0.15 times of the quality of ginkgo leaves, put to room temperature, add 90% ethanol, make the alcohol content to 78%, the solution after alcohol precipitatio...

Embodiment 3

[0055] The invention provides a method for preparing an injection containing a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, comprising the following steps:

[0056] (1) After getting Ginkgo biloba pulverization, add 93% ethanol and reflux extraction 2 times, each reflux extraction time is 0.4 hour, the quality of adding 93% ethanol at every turn is 9 times of Ginkgo biloba quality; Filter, gained filtrate is decompressed Concentrate to 0.25 times the mass of Ginkgo biloba, refrigerate for 51 hours;

[0057] (2) Scrape off the slick oil and take off the lower layer liquid;

[0058] (3) Add water for injection to 0.4 times of the quality of ginkgo leaves in the lower layer liquid, and refrigerate for 45 hours; filter, concentrate the filtrate under reduced pressure to 0.25 times of the quality of ginkgo leaves, put to room temperature, add 93% ethanol, make the alcohol content to 82%, the solution after alcohol precipitation was refrigera...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention belongs to the field of pharmaceutical composition, and particularly relates to pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, an application of thepharmaceutical composition and an injection prepared from the pharmaceutical composition. The pharmaceutical composition contains quercetin-3-O-beta-D-glucosyl (1-2)-alpha-L-rhamnoside, narcissoside,kaempferol-3-O-beta-D-glucosyl(1-2)-alpha-L-rhamnoside, D-pinitol, 5-O-methyl-myo-inositol and ginkgolide A, B and C, and the components are mutually cooperative to be clinically applied to treatmentof the cardiovascular and cerebrovascular diseases; particularly with addition of the D-pinitol and 5-O-methyl-myo-inositol in a specific ratio, the efficacy of the pharmaceutical composition is remarkably better than that of the existing Shuxuening injection; besides, ingredients are clear, quality is controllable, and accordingly, curative effect and medication safety are guaranteed. The invention further provides a preparation method of the pharmaceutical composition. 90%-95 % ethanol is adopted for reflux extraction, cation and anion resin is adopted successively for adsorption treatment,so that the components can be effectively separated, the process is simple, and the preparation method facilitates industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, and in particular relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its application and an injection prepared therefrom. Background technique [0002] Cardiovascular and cerebrovascular diseases generally refer to ischemic or hemorrhagic diseases of the heart, brain, and systemic tissues caused by factors such as hypertension, hyperlipidemia, blood viscosity, and atherosclerosis. Cardiovascular and cerebrovascular diseases have the characteristics of "high morbidity, high disability rate, high mortality rate, high recurrence rate, and many complications", that is, "four highs and one high". At present, there are more than 270 million patients with cardiovascular and cerebrovascular diseases in my country, and nearly 3 million people die from cardiovascular and cerebrovascular diseases in China every year, accounting for 51% of the total an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/075A61K31/365A61K36/16A61P9/00A23G3/36A23G3/48A23L33/105
Inventor 王锋杨满辉
Owner 朗致集团江西医药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap