Genistein methyl ether-containing nanoliposome, preparation method therefor, and cosmetic composition comprising same

A cosmetic composition, nano-liposome technology, applied in the directions of cosmetics, cosmetic preparations, cosmetic preparations, etc., can solve the problems of storage stability, odor or discoloration, tendency of consumers to avoid, and high unit price, Achieve high stability and efficacy, improve stability over time, and improve instability

Active Publication Date: 2018-01-19
KOLMAR KOREA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high unit price of lecithin derived from egg yolk and the fact that it is derived from animals, consumers tend to avoid it, and there are serious problems caused by the decrease in storage stability, especially the stability to heat and light. Due to the problem of odor or discoloration, the conventional technology using lecithin vesicles cannot be regarded as a technology suitable for the stabilization of active ingredients and effective efficacy delivery

Method used

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  • Genistein methyl ether-containing nanoliposome, preparation method therefor, and cosmetic composition comprising same
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  • Genistein methyl ether-containing nanoliposome, preparation method therefor, and cosmetic composition comprising same

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Experimental program
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preparation example Construction

[0066] A second aspect of the present invention provides a method for preparing genistein-containing nanoliposomes, comprising: mixing the water phase components and the oil phase components to form a first mixture; mixing in the first mixture Genistein to form a second mixture; and the step of applying pressure to the second mixture.

[0067] In the step of forming the first mixture of the present invention, the above-mentioned first mixture may comprise about 0.5% by weight to about 10% by weight of glyceride, about 50% by weight to about 70% by weight of water phase components, and about 0.1% by weight of surfactant to about 5% by weight, oils from about 0.1% to about 20% by weight, and softeners from about 8% to about 12% by weight.

[0068] The above-mentioned glyceride may contain an α-hydroxy acid derivative having both a hydrophilic group and an lipophilic group, and may be in the form of de-oxirane (EO). The above-mentioned glycerides may be included in the group con...

experiment example 1

[0098] Experimental example 1: Whitening activity of genistein

[0099] In order to measure the whitening activity, B16F1 (mouse melanoma, ATCC, USA) cells were used to measure the effect of inhibiting melanin biosynthesis of genistein, and the following experiment was performed.

[0100]First, B16F1 cells were cultured in 10% FBS-DMEM (fetal bovine serum-Dulbeco'smodified Eagle's medium; Gibco, USA), and prepared into a cell solution whose cell concentration was adjusted to 5.0×104cell / ml. After dispensing every 2ml of the cell solution into a 6-well plate, at 37°C, 5% CO 2 Incubate in an incubator for 24 hours. After culturing for 24 hours, the medium was removed, and 1.8 ml of medium prepared to a final concentration of 0.2 μM α-MSH (Sigma, USA) and 200 μl of samples of different concentrations were mixed, and cultured again under the same conditions for 72 hours. At this time, as for the negative control group (Blank), only the medium to which α-MSH was not added was add...

experiment example 2

[0159] Experimental Example 2: In vivo test of whitening activity of oil-in-water composition

[0160] The composition of the oil-in-water cosmetic composition based on Example 3 (test group) is shown in Table 5, and the concentration of genistein in the composition is 25ppm (relative to the overall composition, G.M.E-containing nano lipid Body concentration is 500ppm). The test period was 8 weeks, and 24 admitted women in their 30s to 50s were subjects, and in-vivo clinical trials were implemented. The method of application is that the subject personally applies the artificially induced pigmentation twice a day, and after applying the sample for 2 weeks, 4 weeks, and 8 weeks, the equipment is evaluated using Mexameter (MX-18, CK ELECTRONIC GMBH GERMANY) And based on the naked eye evaluation of the dermatologist doctor and the evaluation of the test subject questionnaire, they are shown in Table 6.

[0161] [Table 6]

[0162]

[0163] First of all, according to the clini...

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Abstract

The present invention relates to a nanoliposome and a cosmetic composition containing a genistein methyl ether which exhibits excellent whitening activity and, more specifically, a genistein methyl ether-containing nanoliposome, a preparation method therefor, and a cosmetic composition comprising the same, wherein the genistein methyl ether-containing nanoliposome has excellent storage stability and is capable of maximizing whitening improvement efficacy by completely dissolving genistein methyl ether, which is a poorly soluble substance, using polyol and ethanol, and preparing a nanoliposomewith a glyceryl ester vesicle. In addition, the present invention can effectively realize the protection and skin delivery of active ingredients in color cosmetics, such as BB cream and sunscreen, which are formulations having high salt concentration.

Description

technical field [0001] The present invention relates to nanoliposomes and cosmetic compositions containing genistein methylether (G.M.E) exhibiting excellent whitening activity, and more specifically relates to the complete dissolution of genistein methylether (G.M.E), which is a poorly soluble substance, with polyhydric alcohol and ethanol. Ether, and use glyceride vesicles to carry out nano liposomes, thereby excellent in storage stability and can maximize the effect of whitening and improving genistein-containing nano liposomes and its preparation method and cosmetics containing it combination. Background technique [0002] At present, the whitening functional substances that exhibit whitening effects determined by the Food and Drug Administration can be roughly divided into oil-soluble substances and water-soluble substances. Examples of water-soluble whitening functional substances include arbutin, niacinamide, and ascorbyl glucoside, and examples of oil-soluble whiten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/49A61K8/34A61Q19/02
CPCA61K8/14A61K8/34A61K8/49A61Q19/02
Inventor 洪元基金东明
Owner KOLMAR KOREA
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