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Medicine compound preparation for treating obese hypertensives and preparation method thereof

A technology of obese hypertension and compound preparations, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve the effects of reducing contraindications, strengthening the antihypertensive effect, and significant curative effect

Inactive Publication Date: 2018-03-06
郭裴哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Obese hypertensive patients need to lose weight and lower blood pressure. Currently, there is no effective drug for obese hypertensive patients on the market. Therefore, finding effective intervention drugs has very important theoretical significance and application value

Method used

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  • Medicine compound preparation for treating obese hypertensives and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In terms of parts by weight, 10 parts of nifedipine, 5 parts of metoprolol, and 15 parts of sibutramine were taken, and clinically acceptable auxiliary materials were used to prepare respectively nifedipine sustained-release pellets, metoprolol sustained-release pellets, and metoprolol sustained-release pellets. release pellets and sibutramine sustained-release pellets, and then mix them into capsules to obtain drug compound capsules.

Embodiment 2

[0018] In terms of parts by weight, 8 parts of nifedipine, 4 parts of metoprolol and 10 parts of sibutramine were taken, and clinically acceptable auxiliary materials were used to prepare respectively nifedipine sustained-release pellets, metoprolol sustained-release pellets, and metoprolol sustained-release pellets. release pellets and sibutramine sustained-release pellets, and then mix them into capsules to obtain drug compound capsules.

experiment example

[0028] 600 obese hypertensive patients were randomly divided into 6 groups, wherein the first group took the drug compound capsules prepared in Example 1, the second group took the drug compound capsules prepared in Example 2, and the third group took the drug compound capsules prepared in Comparative Example 1. Drug compound capsules, the fourth group took the drug compound capsules prepared in comparative example 2, the fifth group took the drug compound capsules prepared in comparative example 3, and the sixth group took the sibutramine capsules prepared in comparative example 4, each patient’s daily The dosage is the same, both are 2 capsules. After taking it for 12 months, measure the patient's body weight and blood pressure, the results are shown in Table 1:

[0029] Table 1

[0030]

[0031] It can be seen from Table 1 that the drug compound capsule composed of nifedipine, metoprolol and sibutramine can treat obesity and hypertension at the same time, which is not on...

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Abstract

The invention relates to a medicine compound preparation for treating obese hypertensives and a preparation method thereof. The effective active ingredients of the medicine compound preparation for treating the obese hypertensives comprise nifedipine, metoprolol and sibutramine. The medicine compound preparation is creatively prepared from sibutramine, nifedipine and metoprolol, the purposes thatsibutramine can lose weight, nifedipine and metoprolol medicine can bring high blood pressure down can be achieved, and through a large amount of experimental findings, the medicine compound preparation composed of the nifedipine, metoprolol and sibutramine has significant efficacy on treatment of obese hypertension.

Description

technical field [0001] The invention relates to a compound preparation of western medicine, in particular to a compound preparation of medicine for treating obese hypertensive patients and a preparation method thereof. Background technique [0002] Obesity-induced hypertension is a common clinical problem. Epidemiological studies have shown that obesity is one of the important risk factors for hypertension. The relative risk of hypertension increases significantly with the increase of body mass index. At the same time, obesity and high Blood pressure and both are important risk factors for cardiovascular disease, and when the two exist at the same time, the risk factors are more serious. According to statistics, the incidence of hypertension is 10-15%, of which 10-40% is accompanied by obesity or overweight. The incidence of hypertension in obese people is significantly higher than that in non-obese people, which is a fact confirmed by clinical observation. [0003] Obese ...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/138A61K31/137A61P9/12A61P3/04A61P9/10
CPCA61K31/4422A61K31/137A61K31/138A61K2300/00
Inventor 郭裴哲
Owner 郭裴哲
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