Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of diphenyl ether compound and its preparation method and application

A technology of diphenyl ethers and compounds, which is applied in the field of phytochemistry, can solve problems such as applications that have not been reported yet, achieve good free radical scavenging activity and antioxidant activity, simple extraction process, and wide source of raw materials

Active Publication Date: 2020-06-16
CHINA TOBACCO YUNNAN IND
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention separates a diphenyl ether compound from Flos Lonicerae, and activity studies show that the compound has good antioxidant activity, but no related reports have been seen on the compound and its use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of diphenyl ether compound and its preparation method and application
  • A kind of diphenyl ether compound and its preparation method and application
  • A kind of diphenyl ether compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1-compound

[0039] The honeysuckle sample comes from Kunming, Yunnan, and the variety is Honeysuckle Tree No. 3. Sampling 2.5 kg of dried honeysuckle, pulverized and extracting 5 times with 95% methanol for 30 minutes each time. The extracts were combined, filtered, and concentrated under reduced pressure to obtain an extract to obtain 165 g of extract. The extract is dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 180 g of 100 mesh thick silica gel, and 1.2 kg of 160 mesh silica gel is packed for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone eluted part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 64% methanol as mobile phase, Zorbax SB-C18 (21.2×250mm, ...

Embodiment 2

[0040] The preparation of embodiment 2-compound

[0041] The honeysuckle sample comes from Linyi, Shandong Province, and the variety is Beihua No. 1. The dried honeysuckle sample is crushed to 30 mesh, 4.2kg is sampled, extracted 4 times with 95% ethanol, each extraction is 35 minutes, the extracts are combined, filtered, Concentrated under reduced pressure to obtain an extract, 302 g of extract was obtained. The extract is dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 320 g of 80 mesh thick silica gel, and 1.8 kg of 200 mesh silica gel is packed for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone eluted part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 64% methanol as mobile phase, Zorbax SB...

Embodiment 3

[0042] The preparation of embodiment 3-compound

[0043] The honeysuckle sample comes from Emei, Sichuan, and the variety is Shandong Fujimoto Damaohua. Sampling 5.8kg of honeysuckle was crushed, and extracted 3 times with 75% acetone by ultrasound, each time for 50 minutes. The extracts were combined, filtered, and concentrated under reduced pressure to form an extract. , to obtain extract 427g. After dissolving the extract with 1.6 times the amount of pure methanol by weight, mix the sample with 480g of 90 mesh thick silica gel, pack 3.2kg of 180 mesh silica gel into a column for silica gel column chromatography, and use a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone eluted part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 64% methanol as mobile phase, Zorbax SB-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a diphenyl ether compound as well as a preparation method and application thereof. The compound is prepared by the following steps: extract taking from flos lonicerae, column chromatography on silica gel and separation and purification by high pressure liquid chromatography, wherein the molecular formula of the compound is C20H22O4, the structural formula is shown in the description, and the compound is named flos lonicerae diphenyl ether-D. Experiments prove that the compound has high free radical scavenging activity and antioxidant activity and can be used for preparing an antioxidant for flavors and fragrances so as to inhibit oxidative deterioration of the flavors and fragrances and prolong the shelf life of the flavors and fragrances.

Description

technical field [0001] The invention belongs to the technical field of phytochemistry, and in particular relates to a diphenyl ether compound extracted from honeysuckle for the first time, and the compound has good antioxidant activity. At the same time, the invention also relates to a preparation method of the compound and an application of the compound in inhibiting oxidative deterioration of flavors and fragrances for tobacco. Background technique [0002] Tobacco flavor and fragrance is an additive specially used for flavoring and flavoring of various tobacco products. It is generally divided into natural flavor and artificial flavor. It is one of the core technologies of the tobacco industry to coordinate aromas, make different types and grades of tobacco aromas organically combine and coordinate with each other, and cover up or dilute miscellaneous odors. However, many aroma compounds in tobacco flavors and fragrances contain unsaturated double bonds that are easily o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/78C07C49/255A24B15/26A24B15/30
CPCA24B15/26A24B15/303C07C45/78C07C49/255
Inventor 李晶陈章玉蒋次清王晋刘欣李雪梅许永孔维松杨叶昆耿永勤周敏杨光宇胡秋芬
Owner CHINA TOBACCO YUNNAN IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com