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Piper laetispicum extract as well as preparation method and application thereof

A technology of betel leaf extract, which is applied in the medical field, can solve the problems of no active ingredient separation and identification, antidepressant effect to be improved, undisclosed extract, etc.

Active Publication Date: 2018-03-27
SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it does not disclose which components are contained in the extract, nor does it separate and identify the specific active components in the extract, nor does it measure the content of the active components. In fact, some extracts with unclear active components are obtained.
[0019] However, the antidepressant effect of the extract obtained by the current preparation method still needs to be improved.

Method used

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  • Piper laetispicum extract as well as preparation method and application thereof
  • Piper laetispicum extract as well as preparation method and application thereof
  • Piper laetispicum extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Take the roots and rhizomes of betelwort, coarsely crush them, add an appropriate amount of ethanol with a volume concentration of 95% and soak at room temperature for 24 hours, then add ethanol with a volume concentration of 95% to 20 times the amount, carry out percolation extraction, and concentrate the percolation liquid under reduced pressure to contain The amount of alcohol is 40%, and the concentration temperature is 60°C to obtain the concentrated crude extract of Pincus beteles; 40% ethanol solution, 60% ethanol solution for elution, and the eluate was discarded; continue to elute with 6 times the volume concentration of 95% ethanol, collect the eluate, concentrate to viscous, vacuum dry, concentrate and The drying temperature is 60°C, and the extract of betel is obtained.

[0055] The obtained extract was subjected to repeated silica gel column chromatography, recrystallization, medium-pressure rapid preparation and high-performance liquid chromatography to ob...

Embodiment 2

[0120] Take the roots and rhizomes of betelwort, coarsely crush them, add an appropriate amount of ethanol with a volume concentration of 95% and soak at room temperature for 24 hours, then add ethanol with a volume concentration of 95% to 20 times the amount, carry out percolation extraction, and concentrate the percolation liquid under reduced pressure to contain The amount of alcohol is 40%, and the concentration temperature is 60°C, to obtain the crude extract of Pincus beteles. 2 times the volume concentration of 65% ethanol solution for elution, and the eluent was discarded; continue to elute with 6 times the volume concentration of 95% ethanol, collect the eluate, concentrate until viscous, vacuum dry, concentrate and dry The temperature is 60°C, and the extract is obtained. The yield of the extract is 1.21%. Through HPLC detection, the extract includes sesamin, (2E,6E)-N-isobutyl-7-(3,4-methylenedioxyphenyl) heptadiene Amide, (2E,4E)-N-isobutyldodeca-2,4-dienamide, (2...

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Abstract

The invention relates to piper laetispicum extract as well as a preparation method and application thereof. The piper laetispicum extract comprises any one or a combination of more than one of sesamin, (2E,6E)-N-isobutyl-7-(3,4-methylenedioxyphenyl)heptadiene amide, (2E,4E)-N-isobutyldodecenyl-2,4-diamide, (2E,4E)-N-isobutyl-15-phenyl-2,4-diamide, (2E,4E,14Z)-N-isobutyl icosane-2,4,14-trienamide,(2E,4E)-N-isobutyl-13-phenyl-2,4-diamide. The piper laetispicum extract is obtained by improving a preparation method, and chemical components of the extract are separated and identified, so that compounds contained in the extract are clarified; in addition, the piper laetispicum extract obtained by virtue of the preparation method of the invention is apparent in anti-depression effect and good insafety.

Description

technical field [0001] The invention belongs to the field of medical treatment, and in particular relates to an extract of betelwort and its preparation method and application. Background technique [0002] Piper laetispicum C.DC is a plant of the genus Piper in the family Piperaceae, mainly distributed in Guangdong, Guangxi, Yunnan and Hainan provinces in my country. Folks are used for invigorating blood circulation, reducing swelling, and relieving pain, and mainly treating bruises, congestion, swelling and pain. [0003] Depression has become one of the most important diseases that hinder human health. About 12% to 25% of people in the world will face depression in their lifetime. As a common disease in the world, it is currently estimated that about 350 million patients are suffering from depression, and the age distribution has also changed from covering all age groups to a younger age trend. [0004] After years of systematic research, animal experiments and clinical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/67A61P25/22A61P25/24A61P25/00C07C231/24C07C233/09C07C233/11C07D493/04C07D317/60A61K31/36A61K31/16A61K31/165A23L33/105
CPCA61K36/67A61K2236/333A61K2236/55A61K2236/51A61P25/22A61P25/24A61P25/00A23L33/105A23V2002/00A61K31/16A61K31/165A61K31/36C07D317/60C07D493/04C07D317/64A61P25/18A61K2236/53A23V2200/322A61K9/0053A61K31/166A61K31/357A61K2236/10
Inventor 丁秀娟陈武朱莹莹季佳炜蒋毅
Owner SUZHOU YI HUA BIOMEDICAL TECH CO LTD
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