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Application of roxburgh rose glycoside in preparation of anti-depression products

An antidepressant, prickly pear glycoside technology, applied in the field of medicine, can solve problems such as the antidepressant activity of prickly pear

Pending Publication Date: 2022-03-04
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there has been no relevant report on the antidepressant activity of Rosa roxburghii

Method used

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  • Application of roxburgh rose glycoside in preparation of anti-depression products
  • Application of roxburgh rose glycoside in preparation of anti-depression products
  • Application of roxburgh rose glycoside in preparation of anti-depression products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1: prickly glycoside preparation method:

[0025] Fresh Rosa roxburghii fruit (20kg) is washed and chopped, extracted 3 times with 80% ethanol under reflux, each time for 2 hours, filtered, combined extracts, concentrated under reduced pressure to no alcohol smell, transferred to a water bath (60°C ) is concentrated into medicinal extract, obtain medicinal extract 1.15kg, adopt silica gel column chromatography to carry out preliminary separation to sample by medicinal extract, select chloroform:methanol=10:1,5:1,1:1,0:1 to make eluent , to obtain four parts, wherein A part 11g, B part 97g, C part 69g, D part 263g; then part B was eluted with chloroform:methanol=10:1, 8:1, 5:1, and collected 8:1 The eluted part obtained compound 1, i.e. pricklyside (650mg), with a purity of 98%; its spectrum data are as follows:

[0026] Compound 1: white powder (methanol); ESI-MS m / z 673[M+Na]+; 1 H NMR (600MHz, CD 3 OD) δ: 5.35 (1H, d, J=12.0Hz, glc-1), 5.32 (1H, br s, H-...

Embodiment 2

[0028] Embodiment 2: the application of pricklyside in the preparation of antidepressant products:

[0029] As a single active ingredient, pricklyside is added to pharmaceutical carriers or excipients (one or more solids, semi-solids, liquid diluents, fillers and pharmaceutical product adjuvants) to make a treatment for depression (including endogenous Depression characterized by depression, reactive depression, learning difficulties, etc., and drug-induced secondary depression, postpartum depression, menopausal depression) pharmaceutical preparations (dosage forms can be tablets, capsules, dripping pills or Granules), the effective dose is 10mg / kg.

Embodiment 3

[0030] Embodiment 3: the application of pricklyside in the preparation of antidepressant products:

[0031] Use pricklyside and other medicinal ingredients with antidepressant activity in combination, add pharmaceutical carriers or excipients (one or more solid, semisolid, liquid diluents, fillers, and pharmaceutical product adjuvants) to prepare Pharmaceutical preparations for the treatment of depression (including endogenous depression, reactive depression, depression characterized by learning difficulties, etc., and drug-induced secondary depression, postpartum depression, and menopausal depression) (the dosage form can be Tablets, capsules, dropping pills or granules), the effective dose is 1mg / kg.

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Abstract

The invention discloses an application of roxburgh rose glycoside in preparation of an anti-depression product. Various animal model experiments prove that the roxburgh rose glycoside has an exact curative effect on depression, and the action effect of the roxburgh rose glycoside is equivalent to or better than that of amitriptyline serving as a positive control drug; as a main chemical component and a natural active substance of a medicinal and edible resource roxburgh rose, the roxburgh rose glycoside has high safety and human body adaptability, has small side effects on a human body, and has creative significance in research and application of anti-depression; experimental research shows that the roxburgh rose glycoside has the potential and prospect of being developed into anti-depression drugs, health care products and healthy food, a foundation is laid for developing the drugs and food for treating depression, and a new way is provided for comprehensive utilization of roxburgh rose fruits, roxburgh rose pomace and roxburgh rose branches, leaves and rhizomes.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of pricklyside in the preparation of antidepressant products. Background technique [0002] Depressive disorder is the disease with the second largest disability rate in the world after cardiovascular disease. It is a complex neurological and psychological disease caused by multiple factors. So far, its pathogenesis has not been fully elucidated. The effective treatment of drugs is still a difficult problem facing the world. Antidepressants commonly used in clinical practice are mainly tricyclics, serotonin reuptake inhibitors and monoamine oxidase (MAO) inhibitors. However, these drugs have long medication cycles, severe adverse reactions, easy relapse after drug withdrawal, and high liver toxicity. Therefore, the study of safe and effective antidepressant drugs is a key development direction in the current research field. [0003] Prickly pear (Rosa roxbur...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A23L33/105A61P25/24
CPCA61K31/7024A61P25/24A23L33/105A23V2002/00A23V2200/322A23V2250/21Y02A50/30
Inventor 杨小生陈发菊李良群汪涛李立郎王瑜李齐激杨礼寿杨娟
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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