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Preparation method of muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine

A dual inactivated vaccine and goose parvovirus technology, applied in biochemical equipment and methods, antiviral agents, viruses/bacteriophages, etc., can solve the problems of lack of vaccines, effective immunity, etc., and achieve stress response and protection rate High and early antibody effect

Inactive Publication Date: 2018-04-06
TIANJIN RINGPU BIO TECH
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  • Abstract
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Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides a method for preparing a dual inactivated vaccine of muscovy duck-derived goose parvovirus and duck type 2 adenovirus, so as to solve the technical problem of lacking such vaccines in the prior art
[0006] Another technical problem to be solved by the present invention is the technical problem that in the prior art, it is difficult for the double vaccine with muscovy duck-derived parvovirus and adenovirus as antigens to produce effective immunity to the two viruses at the same time

Method used

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  • Preparation method of muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine
  • Preparation method of muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine
  • Preparation method of muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine

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Embodiment Construction

[0024] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0025] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

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Abstract

The invention provides a preparation method of a muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine. The preparation method is characterized in that targeted process conditions are designed according to the proliferation characteristics and immunogenicity of the muscovy duck original goose parvovirus and the duck type II adenovirus. Concretely, chick embryos are used for proliferating the muscovy duck original goose parvovirus; LMH cells are used for proliferating adenovirus; after being inactivated, the viruses are prepared into safe and effective muscovy duck original goose parvovirus and the duck type II adenovirus combined inactivate vaccine. When being used, the prepared muscovy duck original goose parvovirus and duck type II adenovirus combined inactivate vaccine has the advantages that the antibody generation is early; the protection rate is high. The vaccine can be used for preventing two diseases after once inoculation; the stress response caused by multi-time vaccine inoculation of the muscovy duck can be solved.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, and further relates to a vaccine preparation technology, in particular to a preparation method for a dual inactivated vaccine of muscovy duck-derived goose parvovirus and duck type 2 adenovirus. Background technique [0002] Muscovy duck and gosling plague has been an outbreak in the Muscovy duck breeding areas of Fujian Province since 1997, and it is currently occurring in all duck breeding areas across the country. Clinically, Muscovy ducks are mainly characterized by diarrhea and intestinal mucosa shedding to form embolism, with a morbidity rate of 50-70% and a mortality rate of 40-60%. The clinical use of Muscovy duck parvovirus live vaccine and gosling plague hyperimmune yolk antibody can not control the disease, causing greater economic losses to the duck industry. [0003] Avian adenoviruses are divided into I, II, and III subgroups. At present, experts and scholars...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/235A61K39/23A61P31/20C12N7/00
Inventor 李守军张立霞李亚杰郁宏伟康亚男陈冰郑文卿刘海霞王艳晓
Owner TIANJIN RINGPU BIO TECH
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