Myricetin complex with synergistic effect and preparation method thereof

Abstract

The invention discloses a myricetin complex with synergistic effect. The myricetin complex adopts myricetin as the main drug, and is characterized in that the complex also includes Rebaudioside A as the pharmaceutical adjuvant, the myricetin main drug and the Rebaudioside A pharmaceutical adjuvant are in a mass ratio of 1:15-1:30, and the Rebaudioside A (with a registration number of 58543-16-1, amolecular formula of C44H70O23, and a molecular weight of 967.03) has purity of greater than or equal to 98%. According to the myricetin complex prepared by the method provided by the invention, in an aqueous solution, Rebaudioside A spontaneously forms micelle solubilized myricetin, the myricetin solubility can reach 14.72mg / ml, and the micelle particle size is small, the distribution range is uniform, and the drug stability is good, also the absorption of myricetin after oral administration is improved significantly, and the oral bioavailability is improved, at the same time, Rebaudioside Ahas antidiabetic, anti-inflammatory and other activities, so that the myricetin complex has very good synergistic pharmacological activity. The preparation process of the myricetin complex provided by the invention is simple, is suitable for large-scale industrial production, and has good economical efficiency.

Description

technical field [0001] The invention relates to a myricetin compound, in particular to a myricetin compound with synergistic effect and a preparation method thereof. Background technique [0002] Myricetin (Myricetin, CAS No. 529-44-2) is a polyphenolic compound widely present in natural plants. It has various pharmacological activities such as preventing and treating cardiovascular diseases, anti-tumor, and anti-oxidation. The latest research shows that, Because myricetin has a wide range of pharmacological activities such as significant anti-oxidation, anti-inflammation, and free radical scavenging, it has broad application prospects in the treatment of diabetes and its complications, such as diabetic keratopathy. However, myricetin has poor stability, insoluble in water, low oral bioavailability, and short half-life, which limits its clinical application. Therefore, it is necessary to further explore an economical and effective new myricetin preparation or product. [00...

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