AIE bioprobes emitting red or yellow fluorescence

A technology of aggregation-induced luminescence and probes, applied in luminescent materials, triarylamine dyes, organic chemistry, etc., can solve problems such as limited solution operation conditions, low sensitivity, and susceptibility to environmental influences

Inactive Publication Date: 2018-05-18
THE HONG KONG UNIV OF SCI & TECH
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  • Claims
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Problems solved by technology

In general, most of the prior art references face some problems such as low sensitivity, complex ...

Method used

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  • AIE bioprobes emitting red or yellow fluorescence
  • AIE bioprobes emitting red or yellow fluorescence
  • AIE bioprobes emitting red or yellow fluorescence

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Embodiment Construction

[0095] definition:

[0096] The following definitions are provided for understanding the subject matter and for constructing the appended patent claims.

[0097] Note that, as used in this specification and the appended claims, the singular forms "a", "an" and "the" also include plural referents unless the context clearly dictates otherwise.

[0098] "Aggregation-induced luminescence" means that fluorescence / phosphorescence is turned on when aggregates are formed or solid state. When the molecules dissolve, the material is not emitting. However, when intramolecular rotation is constrained, emission is turned on.

[0099] "Emission intensity" refers to the magnitude of fluorescence / phosphorescence typically obtained from fluorescence spectrometer or fluorescence microscope measurements.

[0100] "Fluorophore" refers to a molecule that exhibits fluorescence.

[0101]By "activated light" is meant a molecule that exhibits luminescence.

[0102] "AIEgen"refers to a molecule ex...

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Abstract

The present subject matter relates to red emitting mitochondria-targeted aggregation induced emission (AIE) probes as an indicator for membrane potential and mouse sperm activity. The present subjectmatter relates to AIE-active fluorescent probes for reactive oxygen species (ROS) detection and related biological applications, such as inflammation imaging and glucose assay, as well as the preparation and application of red fluorescent AIEgens.

Description

[0001] related application [0002] Application Statement for this Patent Provisional U.S. Patent Application No. 62 / 231,805 filed on July 16, 2015, Provisional U.S. Patent Application No. 62 / 283,303 filed on August 27, 2015 and Applied Provisional US Patent Application No. 62 / 285,826, all of which were filed by the inventors and are incorporated herein by reference. technical field [0003] The subject of the present invention relates to the use of red mitochondria-targeted aggregation-induced emission (AIE) probes as membrane potential and mouse sperm activity indicators. The present invention relates to the preparation and application of AIE-active fluorescent probes and red fluorescent pro-AIE for reactive oxygen species (ROS) detection and related biological applications such as inflammation imaging and glucose determination. The subject of the present invention relates to the use of red mitochondria-targeted aggregation-induced emission (AIE) probes as membrane potentia...

Claims

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Application Information

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IPC IPC(8): C09K11/06C07C211/54C07C211/63C07C15/12
CPCC07C251/24C07D209/08C09B23/0058C09B23/0075C09B23/105C09B23/107C09B23/141C09B23/145C09B57/008C09K11/06C09K2211/1425
Inventor 唐本忠赵娜陈斯杰郭子健宋哲刚宋海鹏于义勇威廉姆·亚历山大·尼科尔椰西·罗士
Owner THE HONG KONG UNIV OF SCI & TECH
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