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Use of ginsenoside Rg1 in preparation of drugs for treating fatty liver

A technology of ginsenoside and fatty liver is applied in the application field of medicine to achieve the effect of improving effect, improving the degree of liver damage and steatosis, and good treatment

Inactive Publication Date: 2018-06-01
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, many studies have confirmed the medicinal value of ginsenosides, especially the role in the treatment of liver diseases has received widespread attention, but there is no report on Rg1 for the treatment of NAFLD

Method used

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  • Use of ginsenoside Rg1 in preparation of drugs for treating fatty liver
  • Use of ginsenoside Rg1 in preparation of drugs for treating fatty liver
  • Use of ginsenoside Rg1 in preparation of drugs for treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1, an application of ginsenoside Rg1 in the preparation of a drug for treating fatty liver, the extract powder of ginsenoside Rg1 with a purity greater than or equal to 98% is directly used as a drug powder.

[0017] Animal experiments are used to verify the effects of the above drugs, and the specific process is as follows.

[0018] (1) Experimental animals and reagents

[0019] 6-8 weeks healthy C57BL / 6 female mice (SPF grade), body mass (20±2) g, provided by the Animal Experiment Center of Chongqing Medical University [certificate number: SCXK (Chongqing) 2017-0001];

[0020] High-fat feed (D12492) was purchased from Research Diets Company in the United States, and common feed was provided by the Experimental Animal Center of Chongqing Medical University;

[0021] Main reagents: Ginsenoside Rg1 (purity >98%) was purchased from Dalian Meilun Biotechnology Co., Ltd.; propylene glycol (MDA) and superoxide dismutase (SOD) detection kits were purchased from Nanji...

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PUM

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Abstract

The invention discloses a use of ginsenoside Rg1 in preparation of drugs for treating fatty liver. The invention discovers the new medicinal value of ginsenoside Rg1 and develops its application field. The ginsenoside Rg1 can effectively improve high fat diet-induced liver damage and steatosis. The ginsenoside Rg1 is further used in treatment and remission of fatty liver. The invention provides adrug for treating fatty liver. The drug is prepared only from the ginsenoside Rg1 monomer and is used for treating fatty liver. The drug has good effects of treating and improving non-alcoholic fattyliver.

Description

technical field [0001] The invention relates to the technical field of drugs for treating fatty liver, in particular to the application of ginsenoside Rg1 in the preparation of drugs for treating fatty liver. Background technique [0002] Fatty liver is a fatty lesion of the liver caused by many reasons. In recent years, due to the influence of various factors such as living habits and diet structure, the incidence of fatty liver in my country has gradually increased. The disease can develop into irreversible liver damage in a short period of time, the incidence of fibrosis is as high as 25%, and about 10% of patients can develop into liver cirrhosis. Therefore, the prevention and treatment of fatty liver has become a hot spot in the treatment of liver diseases. From the perspective of the formation mechanism of fatty liver, the disease is divided into alcoholic and non-alcoholic. Among them, non-alcoholic fatty liver disease (Non-alcoholic Fatty Liver Disease, NAFLD) refer...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/16
CPCA61K31/704
Inventor 徐雅姝黄文祥
Owner CHONGQING MEDICAL UNIVERSITY
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