Application of decursinol alpha-angelica lactone to preparation of antiatherosclerosis medicine

A technology of atherosclerosis and angelica fat, applied in the medical field, achieves good safety and effectiveness, improves abnormal blood lipid metabolism, and has no effect of liver and kidney function damage

Inactive Publication Date: 2018-06-08
YUNNAN SECOND PEOPLES HOSPITAL +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report about the anti-atherosclerosis effect of proscurgyl angelica lipid

Method used

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  • Application of decursinol alpha-angelica lactone to preparation of antiatherosclerosis medicine
  • Application of decursinol alpha-angelica lactone to preparation of antiatherosclerosis medicine
  • Application of decursinol alpha-angelica lactone to preparation of antiatherosclerosis medicine

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Embodiment Construction

[0019] The present invention will be further described in detail below in conjunction with the examples.

[0020] Those skilled in the art will understand that the following examples are only for illustrating the present invention and should not be considered as limiting the scope of the present invention. If no specific technique or condition is indicated in the examples, it shall be carried out according to the technique or condition described in the literature in this field or according to the product specification. The materials or equipment used are not indicated by the manufacturer, and they are all conventional products that can be obtained through purchase.

[0021] In the present invention, unless otherwise stated, the percentage symbols represent volume percentages.

[0022] Materials and Methods

[0023] 1. Angelica Ester

[0024] It was proved by column chromatography that angelica ester of procuresinol (Mahat et al, 2012a and Mahat, 2012b), (ElcomSci., Ltd) has...

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Abstract

The invention relates to application of decursinol alpha-angelica lactone to preparation of antiatherosclerosis medicine, and belongs to the technical field of medicine. The angelica effective ingredient of decursinol alpha-angelica lactone is studied; the blood-fat conditioning effect is discovered in ApoE gene knocked mice. The obvious atherosclerosis plaques can be seen in the aorta of the ApoEgene knocked mice; through the feeding of the decursinol alpha-angelica lactone, the atherosclerosis plaques are obviously relieved. Meanwhile, in the adhesion effect with endothelial cells relevantto the atherosclerosis, the decursinol alpha-angelica lactone can inhibit the adhesion of mononuclear cells to endothelial cells and adhesion of LDL and oxLDL induced mononuclear cells to endothelialcells. Through in vitro and in vivo study, the result shows that the decursinol alpha-angelica lactone can relieve the blood lipid metabolism abnormality, and can be used for preventing and treating atherosclerosis. The decursinol alpha-angelica lactone is used and can be prepared into the antiatherosclerosis medicine. The good effect is achieved. The study is good news for wide patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of procuredanol angelica lipid as an anti-atherosclerosis drug. Background technique [0002] The inflammatory response caused by lipid metabolism disorder is the main factor leading to atherosclerosis. Lipids and inflammatory factors cause monocytes to adhere to endothelial cells and lead to atherosclerosis. Oxidized low-density lipoprotein induces lipid accumulation in macrophages leading to atherosclerosis development. [0003] Yunnan province is rich in angelica, and its quality is first-class, and has a long-standing reputation at home and abroad. The traditional production area is in western Yunnan, and Dali, Yunnan, and Heqing angelica are the most famous for their high quality, commonly known as cloud angelica. One of the active ingredients of angelica is angelica ester (Decursinol Angelate), which is the rhizome extract of angelica sinensis...

Claims

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Application Information

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IPC IPC(8): A61K31/222A61P9/10
CPCA61K31/222
Inventor 杨莹杨克周太成李奕平陶文玉吴丽萍
Owner YUNNAN SECOND PEOPLES HOSPITAL
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