Capsule for improving dyslipidemia and application of capsule

A technology of dyslipidemia and capsules, which is applied in the field of capsules for improving dyslipidemia, can solve the problems of unreported research on blood lipid-lowering activity, and achieve the goal of improving changes in adipose tissue and cell morphology, and increasing high-density lipoprotein cholesterol. Effect

Inactive Publication Date: 2018-08-17
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the research on the hypolipidemic effect of Nitraria seeds is only limited to the hypolipidemic effect of Nitraria seed oil, and the research on the hypolipidemic activity of other parts of Nitraria seeds has not been reported.

Method used

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  • Capsule for improving dyslipidemia and application of capsule
  • Capsule for improving dyslipidemia and application of capsule
  • Capsule for improving dyslipidemia and application of capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 Nitraria japonica seed extract capsule:

[0036] This capsule is made up of following raw material percentage by weight:

[0037] Nitraria seed extract 55g, microcrystalline cellulose 15g.

[0038] The specific method is:

[0039] Mix the Nitraria seed extract and microcrystalline cellulose, pass through a 40-60 mesh sieve, homogenize for 10-15 minutes, dry, pack into capsules, and obtain capsules.

[0040] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:10kg / L in a Chinese medicine decocting machine, extraction time 2h, extraction solvent 75% ethanol, The number of times of extraction was 3 times, and the extraction temperature was 65°C. After 3 extractions, the extraction solutions were combined and the ethanol was recovered on a rotary evaporator until there was basically no alcohol smell, then petroleum ether wa...

Embodiment 2

[0041] The preparation of embodiment 2 Nitraria japonica seed extract capsules:

[0042] This capsule is made up of following raw material percentage by weight:

[0043] Nitraria seed extract 5g, microcrystalline cellulose 30g.

[0044] The specific method is:

[0045] Mix the Nitraria seed extract and microcrystalline cellulose, pass through a 40-60 mesh sieve, homogenize for 10-15 minutes, dry, pack into capsules, and obtain capsules.

[0046] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:14kg / L in a Chinese medicine decocting machine, extraction time 2h, extraction solvent 50% ethanol, The number of times of extraction was 3 times, and the extraction temperature was 80°C. After 3 extractions, the extraction solutions were combined and the ethanol was recovered on a rotary evaporator until there was basically no alcohol smell, then petroleum ether wa...

Embodiment 3

[0047] The preparation of embodiment 3 Nitraria japonica seed extract capsules:

[0048] This capsule is made up of following raw material percentage by weight:

[0049] Nitraria seed extract 30g, microcrystalline cellulose 5g.

[0050] The specific method is:

[0051] Mix the Nitraria seed extract and microcrystalline cellulose, pass through a 40-60 mesh sieve, homogenize for 10-15 minutes, dry, pack into capsules, and obtain capsules.

[0052] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:8kg / L in a Chinese medicine decocting machine, extraction time 2h, extraction solvent 95% ethanol, The number of times of extraction was 3 times, and the extraction temperature was 50°C. After 3 extractions, the extraction solutions were combined and the ethanol was recovered on a rotary evaporator until there was basically no alcohol smell, then petroleum ether was...

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Abstract

The invention provides a capsule for improving dyslipidemia. The capsule is prepared from, by weight, 5-55 parts of nitraria tangutorum bobr seed extracts and 5-30 parts of microcrystalline cellulose.A preparation method of the nitraria tangutorum bobr seed extracts includes the steps: taking nitraria tangutorum bobr seeds, and taking ethanol aqueous solution as a solvent to perform extraction; concentrating extracting solution until alcohol taste is omitted; performing extraction by a petroleum ether-water system; taking a water layer, and removing the solvent to obtain the nitraria tangutorum bobr seed extracts. The invention further provides a preparation method and an application of the capsule. Researches show that the nitraria tangutorum bobr seed extracts can reduce total cholesterol, total triglyceride and low-density lipoprotein cholesterin in serums of hyperlipidemia rats, pathological section observation of liver tissues of the rats discovers that the extracts can improve change of fatty tissues and cell morphologies of fatty livers at different levels, and a new selection is provided for clinical prevention or treatment of hyperlipemia or the fatty livers.

Description

technical field [0001] The invention specifically relates to a capsule for improving dyslipidemia, which uses the extract of the water part of the Nitraria thorn seed as a raw material, and its application. technical background [0002] Hyperlipidemia is the main cause of atherosclerosis and related diseases such as coronary heart disease, ischemic brain disease and peripheral vascular disease. Although the incidence of diseases related to atherosclerosis has been improved due to drug treatment and prevention, the above conditions still account for a large proportion of morbidity and mortality in middle-aged and elderly people. Due to the increasing prevalence of obesity and the aging of the world population, the annual incidence and number will increase substantially in the next decade. Dyslipidemia is caused by abnormal blood lipid metabolism, such as the increase of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and the decrease of high-densit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/48A61P3/06A61P1/16A61K131/00
CPCA61K9/4866A61K36/185A61K2236/333A61P1/16A61P3/06
Inventor 周武索有瑞王煜伟杨芳任国慧
Owner QINGHAI UNIVERSITY
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