Curcuma zedoary extract and application thereof in preparation of medicine for preventing and treating coronary heart disease
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The technology of Curcuma curcuma extract and Curcuma curcuma, applied in the fields of biopharmaceuticals and molecular biology, can solve the problems of multiple side effects and insignificant effects of surgery, and achieve the effect of restoring vascular endothelial function, reducing vascular inflammation, and achieving good effects.
Pending Publication Date: 2022-07-12
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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[0005] The purpose of the present invention is to provide a curcuma extract and its application in the preparation of drugs for the prevention and treatment of coronary heart disease in view of the existing problem of improving coronary heart disease drugs and surgery with multiple side effects and insignificant curative effects
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Embodiment 1
[0044] 1. Curcuma decoction pieces:
[0045] Raw curcuma decoction pieces: take Curcuma curcuma medicinal materials, remove impurities, soak slightly, wash, size into different grades, place in a steaming container and steam to a round steam for 40 minutes, cut into thick slices (size 2-4mm) while hot, and dry at 50°C, that is, have to.
[0046] Vinegar curcuma decoction pieces: prepared according to the vinegar cooking method (General Rule 0213) of the 2020 edition of the Chinese Pharmacopoeia. Take net curcuma, divide the size into different grades, add an appropriate amount of rice vinegar and cook it until there is no white heart in the incision, take it out, let it dry until 60% dry, cut it into thick slices (size 2-4mm), and dry it at 50°C. For every 100kg of Curcuma, use 20kg of vinegar.
[0047] 2. Extract:
[0048] The prepared raw and curcuma curcuma decoction pieces were heated and refluxed with 15 times the mass of 90% (v / v) ethanol, and extracted in 2 times, ea...
Embodiment 2
[0139] 1. Curcuma decoction pieces:
[0140] Curcuma curcuma decoction pieces (raw curcuma curcuma decoction pieces, marked as curcuma curcuma decoction pieces in Example 2) were prepared by using the preparation method of Curcuma curcumae decoction pieces in Example 1.
[0141] 2. Curcuma curcuma extract before and after alcohol precipitation:
[0142] Curcuma curcuma extract (before alcohol precipitation): The prepared Curcuma curcuma extracts were heated and refluxed with 15 times the mass of 90% (v / v) ethanol, and extracted in 2 times, each for 1.5h (the first time was 9 times the mass, the second time was 1.5 h). Add 10 times the amount of water to extract the dregs for 1.5h, combine the above extracts, filter, take the filtrate and concentrate under reduced pressure at 50°C to a crude drug content of 1.0g / ml to obtain the Curcuma curcuma extract before alcohol precipitation.
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Abstract
The invention discloses a curcuma zedoary extract and application of the curcuma zedoary extract in preparation of a medicine for preventing and treating coronary heart disease. The curcuma zedoary extract is extracted by the following method: heating and extracting raw or vinegar curcuma zedoary decoction pieces with ethanol; extracting medicine residues with water; and merging the extracting solutions, adding ethanol until the alcohol concentration is 40-60%, standing, filtering, and concentrating the filtrate under reduced pressure until the crude drug content is 0.5-1.0 g/mL. The curcuma zedoary extract can significantly increase the liver index and spleen index of a rat with coronary heart disease, and improve the fatty degeneration, myocardial fibrosis, necrosis and inflammatory infiltration degree of liver cells; indexes such as the whole blood viscosity and the erythrocyte aggregation index of the coronary heart disease rats can be remarkably reduced, and the blood viscous state is reduced; the traditional Chinese medicine composition can significantly improve dyslipidemia, and meanwhile, achieves the treatment effects of relieving vascular cholesterol deposition and inflammation and recovering endothelial functions. Lipiomics results also show that the compound can regulate and control abnormal lipid metabolism of the coronary heart disease by inhibiting sphingolipid metabolism and promoting glyceride metabolism and fatty acyl metabolism.
Description
technical field [0001] The invention belongs to the technical field of biopharmaceuticals and molecular biology, and particularly relates to a curcuma curcuma extract and its application in preparing a medicine for preventing and treating coronary heart disease. Background technique [0002] Coronary atherosclerotic heart disease (CHD), referred to as coronary heart disease, is a disease based on abnormal lipid metabolism and caused by a combination of factors. The pathogenesis of the disease is that under the action of blood stasis, abnormal lipid metabolism and other incentives, lipids are deposited on the coronary intima, and white plaques are formed over time, which is called atherosclerotic lesions. As time prolongs, the degree of arteriosclerosis gradually increases, and the coronary lumen gradually narrows or forms blockage, which causes myocardial ischemia and hypoxia to cause heart disease. In modern Chinese medicine theory, coronary heart disease belongs to the ca...
Claims
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Application Information
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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P9/10A61K125/00
CPCA61K36/9066A61P9/10A61K2236/331A61K2236/333
Inventor 毛春芹陆兔林费程浩梅茜苏联麟季德毛靖顾薇李昱秦宇雯李林董佳佳
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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