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Effervescent tablet for improving dyslipidemia and use thereof

A technology for dyslipidemia and effervescent tablets, which can be applied to medical preparations containing active ingredients, pharmaceutical formulas, metabolic diseases, etc., and can solve problems such as unreported research on blood lipid-lowering activity

Active Publication Date: 2021-04-27
QINGHAI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, the research on the hypolipidemic effect of Nitraria seeds is only limited to the hypolipidemic effect of Nitraria seed oil, and the research on the hypolipidemic activity of other parts of Nitraria seeds has not been reported.

Method used

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  • Effervescent tablet for improving dyslipidemia and use thereof
  • Effervescent tablet for improving dyslipidemia and use thereof
  • Effervescent tablet for improving dyslipidemia and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] The preparation of embodiment 1 Nitraria japonica seed extract effervescent tablet:

[0036] The effervescent tablet is made of the following percentages by weight:

[0037] Nitraria japonica seed extract 55g, citric acid 2~4g, fumaric acid 3~5g, fructooligosaccharide 10g, sorbitol 10g, sodium bicarbonate 2~10g, food flavor 1~5g, aspartame 0.5~1.5 g. 0.1-0.6 g of magnesium stearate.

[0038] The specific method is:

[0039] Mix Nitraria japonica seed extract, citric acid, and fumaric acid, and make granules; take fructooligosaccharides, sorbitol, sodium bicarbonate,

[0040] Food flavor and aspartame are mixed and granulated; after the two granules are dried, mixed evenly, magnesium stearate is added, and tabletted, that is

[0041] Get effervescent tablets.

[0042] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:10kg / L in a Chinese medicine dec...

Embodiment 2

[0043] The preparation of embodiment 2 Nitraria japonica seed extract effervescent tablet:

[0044] The effervescent tablet is made of the following percentages by weight:

[0045] Nitraria seed extract 40g, citric acid 2~4g, fumaric acid 3~5g, fructooligosaccharide 20g, sorbitol 25g, sodium bicarbonate 2~10g, food flavor 1~5g, aspartame 0.5~1.5 g. 0.1-0.6 g of magnesium stearate.

[0046] The specific method is:

[0047] Mix Nitraria japonica seed extract, citric acid, and fumaric acid, and make granules; take fructooligosaccharides, sorbitol, sodium bicarbonate,

[0048] Food flavor and aspartame are mixed and granulated; after the two granules are dried, mixed evenly, magnesium stearate is added, and tabletted, that is

[0049] Get effervescent tablets.

[0050] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:14kg / L in a Chinese medicine decocting ma...

Embodiment 3

[0051] The preparation of embodiment 3 Nitraria japonica seed extract effervescent tablet:

[0052] The effervescent tablet is made of the following percentages by weight:

[0053] Nitraria seed extract 50g, citric acid 2-4g, fumaric acid 3-5g, fructo-oligosaccharide 15g, sorbitol 20g, sodium bicarbonate 2-10g, food flavor 1-5g, aspartame 0.5-1.5 g. 0.1-0.6 g of magnesium stearate.

[0054] The specific method is:

[0055] Mix Nitraria japonica seed extract, citric acid, and fumaric acid, and granulate; take fructooligosaccharides, sorbitol, sodium bicarbonate, edible essence, and aspartame, mix, and granulate; after drying the two granules, Mix well, add magnesium stearate, and press into tablets to obtain effervescent tablets.

[0056] The preparation of Nitraria seed extract: after getting 5kg Nitraria seeds to pulverize through a high-speed universal pulverizer, extract with a solid-liquid ratio of 1:8kg / L in a Chinese medicine decocting machine, extraction time 2h, extra...

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Abstract

The invention provides an effervescent tablet for improving dyslipidemia, which is prepared from raw and auxiliary materials in the following weight ratio: 5-55 parts of Nitraria japonica seed extract, 2-4 parts of citric acid, 3-5 parts of fumaric acid 5 parts, 10-20 parts of fructooligosaccharide, 10-25 parts of sorbitol, 2-10 parts of sodium bicarbonate. The invention also provides the preparation method and application of the effervescent tablet. The research of the present invention shows that the Nitraria japonica seed extract provided by the present invention can reduce total cholesterol, total triglyceride, and low-density lipoprotein cholesterol in the blood serum of hyperlipidemic rats, improve its high-density lipoprotein cholesterol, and can reduce to a certain extent against abnormal weight gain in rats with hyperlipidemia. At the same time, the pathological section observation of the liver tissue of each group of rats also found that the extract can improve the changes of adipose tissue and cell morphology of fatty liver to varying degrees, which provides a good foundation for the clinical prevention or treatment of hyperlipidemia or fatty liver. new options.

Description

technical field [0001] The invention specifically relates to an effervescent tablet for improving dyslipidemia, which uses the extract of the water part of Nitraria thorn seed as a raw material, and its application. [0002] technical background [0003] Hyperlipidemia is the main cause of atherosclerosis and related diseases such as coronary heart disease, ischemic brain disease and peripheral vascular disease. Although the incidence of diseases related to atherosclerosis has been improved due to drug treatment and prevention, the above conditions still account for a large proportion of morbidity and mortality in middle-aged and elderly people. Due to the increasing prevalence of obesity and the aging of the world population, the annual incidence and number will increase substantially in the next decade. Dyslipidemia is caused by abnormal blood lipid metabolism, such as the increase of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C) and the decrea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/46A61P3/06A61P1/16A61K131/00
CPCA61K9/0007A61K9/2018A61K36/185A61K2236/333A61K2236/51A61P1/16A61P3/06
Inventor 周武索有瑞王煜伟杨芳李柯
Owner QINGHAI UNIVERSITY
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