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Method of extracting and purifying rhubarb total anthraquinone from rhubarb

A technology of total anthraquinone and total anthraquinone of rhubarb, applied in the field of medicine, can solve problems such as unfavorable curative effect, and achieve the effects of rapid and efficient extraction, low cost and reduction of impurity amount.

Inactive Publication Date: 2018-06-08
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above methods all heat for a long time to destroy the glycosidic bond of anthraquinone glycosides to obtain free anthraquinone, which is not conducive to maintaining the curative effect of purging

Method used

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  • Method of extracting and purifying rhubarb total anthraquinone from rhubarb

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Weigh 50 g of rhubarb coarse powder, add 9 times the amount of 50% ethanol to soak for 1 h, extract twice by flash extraction, and filter the extract with four layers of gauze. The total anthraquinone content of rhubarb in the extract was determined under the above chromatographic conditions and the extraction rate was calculated.

Embodiment 2

[0026] Weigh 50 g of rhubarb coarse powder, add 9 times the amount of 70% ethanol to soak for 1 h, extract twice by flash extraction, and filter the extract with four layers of gauze. The total anthraquinone content of rhubarb in the extract was determined under the above chromatographic conditions and the extraction rate was calculated.

Embodiment 3

[0028] Weigh 50 g of rhubarb coarse powder, add 9 times the amount of 90% ethanol to soak for 1 h, extract twice by flash extraction, and filter the extract with four layers of gauze. The total anthraquinone content of rhubarb in the extract was determined under the above chromatographic conditions and the extraction rate was calculated.

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Abstract

The invention relates to a method of extracting and purifying rhubarb total anthraquinone from rhubarb. The method comprises the steps of extracting the rhubarb by a flash extraction method, recovering part of alcohol from a rhubarb extract, adding a polymeric flocculant into liquor for adsorption and clarification, taking clear supernate for continued concentration, adding acid to regulate acidity to separate out a precipitate, dissolving the precipitate with alkaline, performing centrifugation to remove impurities, and adding acid to separate out higher-content rhubarb total anthraquinone. Apreparation technology is time-saving, simple and convenient in operation, energy-saving and environment-friendly; a product is free from residual toxic solvent; and the method is suitable for industrial production of rhubarb total anthraquinone by using the rhubarb.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a method for extracting and purifying active components of traditional Chinese medicines, in particular to a method for extracting and purifying total anthraquinones of rhubarb from rhubarb. Background technique [0002] Rhubarb is an important commonly used Chinese medicinal material, which has the effects of purging diarrhea and attacking stagnation, clearing away heat and purging fire, promoting blood circulation and eliminating stagnation. Modern studies have shown that rhubarb has various pharmacological effects such as improving renal insufficiency, catharsis, protecting the liver and gallbladder, antibacterial, antiviral, anti-inflammatory and analgesic, promoting blood circulation and stopping bleeding, lowering blood fat, and anti-tumor. The main active ingredients of rhubarb pharmacological effects include aloe-emodin, rhein, chrysophanol, emodin and emodin methyl ether and othe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708
CPCA61K36/708A61K2236/333A61K2236/53
Inventor 汤淮波张腾罗黎霞
Owner XIANGTAN UNIV
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