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Preparation method for periodontal tissue repairing-type root apex filling material

A technology for filling materials and periodontal tissue, which is applied in the field of preparation of periodontal tissue-type root tip filling materials, can solve the problems of no biological activity, poor biocompatibility, and inability to promote cementum surface deposition, etc., and achieve effective Good for regeneration, promotion of periodontal tissue regeneration, and excellent mechanical strength

Inactive Publication Date: 2018-06-15
常州蓝旗亚纺织品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the existing tooth root tip filling materials have poor biocompatibility and no biological activity, and cannot promote the deposition of cementum on its surface, a tooth root tip filling material for repairing periodontal tissue is provided preparation method

Method used

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  • Preparation method for periodontal tissue repairing-type root apex filling material

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example 1

[0018] In terms of parts by weight, weigh 45 parts of 1% acetic acid solution by mass fraction, 6 parts of chitosan, and 3 parts of tricalcium phosphate in a beaker, stir and mix them and place them under 200W for ultrasonic dispersion for 10 minutes to obtain a dispersion. The volume ratio is 1:1, add 5% β-glycerophosphate sodium solution dropwise to the dispersion, and control the dropping rate at 5mL / min. After the addition is completed, stir and mix with 5% sodium bicarbonate solution Adjust the pH to 7.0 to obtain the matrix liquid, then add 1% osteogenic growth peptide solution dropwise to the matrix liquid at a mass ratio of 1:10, and control the dropping time to 1 hour. After the addition is completed, a gel is obtained solution and sterilized for 3 minutes under an ultraviolet sterilizer to obtain a sterilized gel solution; take bovine bone and pulverize it to obtain bovine bone particles and rinse them with absolute ethanol for 3 times. In a Furnace, activate at 250°...

example 2

[0020] In terms of parts by weight, weigh 47 parts of 1% acetic acid solution by mass fraction, 7 parts of chitosan, and 4 parts of tricalcium phosphate in a beaker, stir and mix them and place them under 250W for ultrasonic dispersion for 12 minutes to obtain a dispersion. The volume ratio is 1:1, add 5% β-glycerophosphate sodium solution dropwise to the dispersion, and control the dropping rate at 5mL / min. After the addition is completed, stir and mix with 5% sodium bicarbonate solution Adjust the pH to 7.0 to obtain the matrix liquid, and then add 1% osteogenic growth peptide solution dropwise to the matrix liquid at a mass ratio of 1:10, and control the dropping time to 2 hours. After the addition is completed, a gel is obtained solution and sterilized for 4 minutes under an ultraviolet sterilizer to obtain a sterilized gel solution; take bovine bone and pulverize it to obtain bovine bone particles and rinse them with absolute ethanol for 4 times. In a Furnace, after activ...

example 3

[0022] In terms of parts by weight, weigh 50 parts of 1% acetic acid solution by mass fraction, 8 parts of chitosan, and 5 parts of tricalcium phosphate in a beaker, stir and mix them and place them under 300W for ultrasonic dispersion for 15 minutes to obtain a dispersion. The volume ratio is 1:1, add 5% β-glycerophosphate sodium solution dropwise to the dispersion, and control the dropping rate at 5mL / min. After the addition is completed, stir and mix with 5% sodium bicarbonate solution Adjust the pH to 7.0 to obtain the matrix liquid, and then add 1% osteogenic growth peptide solution dropwise to the matrix liquid at a mass ratio of 1:10, and control the dropping time to 2 hours. After the addition is completed, a gel is obtained solution and sterilized for 5 minutes under an ultraviolet sterilizer to obtain a sterilized gel solution; take bovine bone and pulverize it to obtain bovine bone granules and rinse them with absolute ethanol for 5 times. In a Furnace, after activa...

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Abstract

The invention relates to a preparation method for a periodontal tissue repairing-type root apex filling material and belongs to the technical field of filling materials. Bovine bone is calcined and then is compounded with tricalcium phosphate so that a base is prepared. Main fillers are hydroxyapatite and hydroxy acid calcium salt, are similar to hard tissue ingredients of the human body, can be effectively compatible with human tissues, have excellent mechanical strength in the human body and can effectively fill the root apex. The gel prepared from chitosan coats the osteogenic growth peptide and slowly releases the osteogenic growth peptide so that periodontal tissue regeneration is promoted. The chitosan gel can effectively promote the regeneration of periodontal tissues in the bifurcation area. Through the interaction between the chitosan gel and the filling material, the growth and development of periodontal tissues are promoted and the development of periodontal tissues is effectively repaired and promoted.

Description

technical field [0001] The invention relates to a preparation method of a tooth root tip filling material for repairing periodontal tissue, and belongs to the technical field of filling materials. Background technique [0002] Dental caries is a kind of common disease, frequently-occurring disease called dental caries, dirty tooth. The incidence rate of dental caries is relatively high, and it is one of the oldest and most common diseases of human beings. The World Health Organization has listed it as the three major human diseases for prevention and treatment along with cancer and cardiovascular diseases, but dental caries is also a chronic disease. Progressive and destructive disease, the early symptoms are not obvious, and patients are often not easy to pay attention to and delay treatment. It can often be secondary to dental caries and periapical disease, and can even cause alveolar bone and jaw bone inflammation. There are many types and forms of tooth root filling mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K6/097A61K6/033A61K6/027A61K6/02A61K6/083A61K6/838A61K6/898
CPCA61K6/80A61K6/831A61K6/838A61K6/887A61K6/898C08L5/08C08L33/02
Inventor 孙春辉季美
Owner 常州蓝旗亚纺织品有限公司
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