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Silica nano material delivery system for capturing and treating circulating tumor cells

A technology of silica and nanomaterials, applied in the field of biological cytology, can solve the problems that chemotherapy drugs cannot distinguish malignant tumor cells, cell death, etc., and achieve the effect of good modification and high specific surface area

Inactive Publication Date: 2018-06-22
上海菱蓝生物科技有限公司
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  • Claims
  • Application Information

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Problems solved by technology

In addition, most current chemotherapy drugs use solid tumors as a target for targeted therapy, but chemotherapy drugs cannot distinguish between malignant tumor cells and normal cells, so while killing cancer cells, they will also kill a large number of normal cells in the human body. Causes the death of bone marrow cells, liver cells and other cells with strong renewal ability

Method used

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  • Silica nano material delivery system for capturing and treating circulating tumor cells
  • Silica nano material delivery system for capturing and treating circulating tumor cells
  • Silica nano material delivery system for capturing and treating circulating tumor cells

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Embodiment

[0018] An embodiment of the present invention provides a silica nanomaterial delivery system for capturing and treating circulating tumor cells, which consists of magnetic mesoporous silica nano (FE3O4-MSNs) microspheres, siRNA drugs and targeting antibodies .

[0019] Magnetic mesoporous silica nanospheres (FE3O4-MSNs) microspheres have adjustable pore size, high specific surface area, and good modification, and are suitable as sustained-release carriers for new biomedicine (including chemotherapy drugs, protein drugs, and nucleic acids, etc.).

[0020] As a novel cancer treatment strategy, siRNA drugs can inhibit and interfere with the expression of cancer-related genes. siRNA drugs include but are not limited to: 1. Epithelial-specific genes: siRNA drugs that interfere with EPCAM gene expression, siRNA drugs that interfere with Cytokeratin7, 8, 18, 19, 20 gene expression, and siRNA drugs that interfere with HEA gene expression. 2. Tumor-specific genes: AKt1 / WTI / H1299 / EZH2 / ...

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Abstract

The invention provides a silica nano material delivery system for capturing and treating circulating tumor cells. The silica nano material is prepared from a magnetic mesoporous silica nano microsphere, a siRNA (small interfering Ribonucleic Acid) medicine and a targeting antibody. The circulating tumor cells (CTCs) are used as liquid biopsy specimens representing a primary tumor, and help to carry out histological identification in real-time and noninvasive manners. The silica nano material delivery system, based on loading the siRNA medicine into the magnetic mesoporous silica nano (FE3O4-MSNs (Mesoporous Silica Nanoparticles)) microsphere and through modification, can be used for recognizing and binding the targeting antibodies (modified by double antibodies CD133 and an EPCAM (Epithelial Cell Adhesion Molecule)) of surface biomarkers of the CTCs; a brand-new FE3O4-MSNs_siRNA@CD133-EPCAM co-loading system is finally developed, and the system can be used for preliminarily realizing the targeting capturing and inhibition on the CTCs.

Description

technical field [0001] The invention relates to the field of biological cytology, in particular to a silicon dioxide nanomaterial delivery system for capturing and treating circulating tumor cells. Background technique [0002] Circulating tumor cells are the only way for distant metastasis of tumors. The presence of tumor cells in peripheral blood indicates the occurrence of tumors with metastatic potential, and benign tumor cells will not enter peripheral blood. Therefore, targeting the detection and inhibition of circulating tumor cells could lead to early treatment of cancer. The silica nanomaterial delivery system for the capture and treatment of circulating tumor cells uses modified magnetic nanoparticles to specifically bind circulating tumor cells and identify circulating tumor cells in the early stages of cancer. In addition, most current chemotherapy drugs use solid tumors as a target for targeted therapy, but chemotherapy drugs cannot distinguish between malign...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/04A61K47/68A61K31/7105A61K48/00A61P35/00
CPCA61K9/501A61K31/7105
Inventor 谌啸王颖
Owner 上海菱蓝生物科技有限公司
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