Compositions comprising 3'-o-glucuronide epicatechin and methods of making and using such compositions
A technology of aldoside expression and aldoside expression, which is applied in the direction of medical preparations containing active ingredients, drug combinations, drug delivery, etc., can solve the problems that the effects of mood and cognitive performance are not very clear, and achieve increased Sympathetic Nervous System Activity, Increases Energy Expenditure, Supports Weight Management Effects
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[0113] The following non-limiting examples present the scientific data that developed and supported the concept of 3'-O-glucuronide epicatechin as a TRPA1 agonist.
[0114] Several epicatechin metabolites were tested in vitro to determine whether any of these compounds were agonists of the cation channel of TRPA1. Specifically, according to Riera et al. (Riera, C.E., Vogel, H., Simon, S.A., Damak, S. and le Coutre, J., Sensory attributes of complex tasting divalent salts aremediated by TRPM5 and TRPV1 channels. (complex tasting The sensory properties of divalent salts are mediated by TRPM5 and TRPV1 channels), J. Neurosci. 29, 2654-2662 (2009)), the calcium imaging method described activation of h-TRPA1 expressing CHO cells was tested.
[0115] Such as Figure 4 The results shown show that 3'-O-glucuronide epicatechin is a TRPA1 agonist. In contrast, the epicatechin metabolite 3'-O-methylepicatechin (chemical structure as Figure 5 shown) is not a TRPA1 agonist, as Figure...
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