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Povidone-iodine solution and preparation method thereof

A povidone-iodine solution technology, which is applied in blood diseases, medical formulas, extracellular fluid diseases, etc., can solve the problems of enhanced iodine permeability and affecting the bactericidal effect of povidone-iodine, so as to improve permeability and improve intestinal Tao health, increase the effect of stability

Active Publication Date: 2018-08-28
GUANGDONG GALLOPER VETERINARY PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Yet current povidone-iodine disinfectant uses organic alcohols though can improve the stability of povidone-iodine, but organic alcohol increases the permeability of skin, makes iodine strengthen to the permeability of skin and cause negative impact, and Organic alcohol molecules have hydroxyl groups, and when they are compatible with strong oxidants such as iodine, they are prone to interact, and can be esterified and etherified, which will affect the bactericidal effect of povidone-iodine products

Method used

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  • Povidone-iodine solution and preparation method thereof
  • Povidone-iodine solution and preparation method thereof
  • Povidone-iodine solution and preparation method thereof

Examples

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Embodiment 1

[0035] Embodiment 1, the preparation of aloe polysaccharide zinc

[0036] A gets the whole leaf juice of aloe, adds dehydrated alcohol, the addition of described dehydrated alcohol is 12 times of the weight of the whole leaf juice of aloe, stirs 45min, filters, reclaims ethanol, obtains filter residue;

[0037] B adds deionized water to the filter residue that step A obtains and carries out ultrasonic extraction 25min, and described ultrasonic power is 550W, and the addition amount of described deionized water is 12 times of filter residue weight, obtains aloe polysaccharide extract;

[0038]C, the aloe polysaccharide extract obtained in step B is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 50,000 to obtain a dialysate, which is then ultrafiltered with an ultrafiltration membrane with a molecular weight of 20,000, concentrated by ultrafiltration for 8 times, and then used Concentrate by nanofiltration membrane 15 times to obtain aloe polys...

Embodiment 2

[0040] Embodiment 2, a kind of povidone-iodine solution

[0041] Described povidone-iodine solution is made up of following composition and weight part thereof:

[0042] 5 parts of povidone iodine, 0.05 part of potassium dihydrogen phosphate, 0.05 part of dipotassium hydrogen phosphate, 0.05 part of potassium iodate, 1 part of glycerin, 2 parts of aloe polysaccharide zinc and 1 part of sodium citrate; The aloe polysaccharide zinc that example 1 makes.

[0043] Preparation:

[0044] S1 Add aloe polysaccharide zinc into deionized water, heat to 70°C and stir until completely dissolved to obtain mixed solution I;

[0045] S2 Add potassium dihydrogen phosphate, dipotassium hydrogen phosphate, potassium iodate, glycerin and sodium citrate into deionized water and stir evenly to obtain mixture liquid II;

[0046] S3 Add the mixed solution II obtained in step S2 to the mixed solution I obtained in step S1, stir evenly, let it stand for 15 minutes, then add povidone-iodine, stir ev...

Embodiment 3

[0047] Embodiment 3, a kind of povidone-iodine solution

[0048] Described povidone-iodine solution is made up of following composition and weight part thereof:

[0049] 8 parts of povidone iodine, 0.8 part of potassium dihydrogen phosphate, 0.85 part of dipotassium hydrogen phosphate, 0.2 part of potassium iodate, 4 parts of glycerin, 3 parts of aloe polysaccharide zinc and 0.6 part of sodium citrate; The aloe polysaccharide zinc that example 1 makes.

[0050] The preparation method is similar to Example 2.

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Abstract

The invention belongs to the technical field of disinfectants, and particularly relates to a povidone-iodine solution and a preparation method thereof. The povidone-iodine solution provided by the invention is prepared from povidone-iodine, monopotassium phosphate, dipotassium phosphate, potassium iodate, glycerinum, aloe zinc-polysaccharide and sodium citrate. The povidone-iodine solution prepared by the preparation method has the advantages of high stability, remarkable sterilizing effect and durable effect. Meanwhile, the povidone-iodine solution provided by the invention also has the effects of stopping bleeding, clearing free radicals in wounds and preventing wound pollution, and can effectively facilitate wound healing. When the povidone-iodine solution is applied to bathing of piglets, the disease infection prevention ability of piglets can be enhanced, and adverse reactions due to stress reaction can be improved, so that the health level of the piglets is raised. The povidone-iodine solution is an ideal disinfection liquid suitable for piglets.

Description

technical field [0001] The invention belongs to the technical field of disinfectants, and in particular relates to a povidone-iodine solution and a preparation method thereof. Background technique [0002] Povidone-iodine (Polyvinlpyrrolidone-iodine, pvp-I), also known as iodophor, is a complex formed with surface-active polyvinylpyrrolidone as a carrier and iodine, and its bactericidal activity is provided by the surfactant PVP against bacteria The affinity of the membrane combines the iodine contained in it with the cell membrane and cytoplasm to oxidize sulfhydryl compounds, peptides, proteins, enzymes, lipids, etc., thereby achieving the purpose of sterilization. Compared with iodine, povidone-iodine has the advantages of low volatility, good water solubility, moderate and long-lasting effect, and safe use. It is a new type of disinfectant for external use with high efficiency, broad spectrum and low toxicity. [0003] Povidone-iodine solution has different degrees of b...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/70A61K31/79A61K31/194A61K47/36A61K47/02A61P31/02A61P17/02A61P7/04
CPCA61K9/08A61K9/7015A61K31/194A61K31/79A61K47/02A61K47/36A61P7/04A61P17/02A61P31/02A61K2300/00
Inventor 李云黄剑华
Owner GUANGDONG GALLOPER VETERINARY PHARMA
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