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A cosmetic composition comprising α-mangostin, its preparation method and its use

A cosmetic composition, mangostin technology, applied in sunscreen or whitening cosmetic composition, cosmetic composition field, can solve the problems of new technology safety, narrow ultraviolet absorption band, lack of new sunscreen, etc., to achieve enhanced photostability Strong solubility and high SPF value

Active Publication Date: 2020-01-14
南京美竹医药科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of sunscreen has the characteristics of high transparency and good absorption effect, but it is irritating to the skin and may cause side effects such as inflammation and allergy. In severe cases, it will interfere with endocrine and have genotoxicity or reproductive toxicity.
In addition, organic sunscreens have photoinstability problems, such as butylmethoxydibenzoylmethane has serious photoinstability problems
[0006] Throughout the global sunscreen product market, the development trend of sunscreen agents is concentrated on: 1) full-band protection has become the main goal of sunscreen products; 2) the sun protection factor (SPF) tends to increase, the higher the SPF value, the higher the amount of UV absorber added 3) Natural sunscreens have become a research hotspot: this type of sunscreen has anti-ultraviolet effect, can eliminate sun damage such as skin redness and spots caused by exposure to the sun, and eliminate the side effects of organic sunscreens; it has mild and safe sunscreen effects However, natural sunscreens generally have weak UV absorption ability, narrow UV absorption band, and weak broad-spectrum sunscreen ability; 4) Composite sunscreens have become the main development direction: the combination of natural sunscreens and organic or inorganic sunscreens can reduce The amount of the original sunscreen agent, improve the safety of the skin, prevent skin side effects caused by organic or inorganic sunscreen agents, etc.
[0007] To sum up, there are various disadvantages and deficiencies in the commonly used sunscreens in the market at present. There is a serious shortage of new sunscreens, the development is relatively slow, and there are safety problems in new technologies, which are far from meeting the current market demand.

Method used

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  • A cosmetic composition comprising α-mangostin, its preparation method and its use
  • A cosmetic composition comprising α-mangostin, its preparation method and its use
  • A cosmetic composition comprising α-mangostin, its preparation method and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The present embodiment is control sample 1, and its composition is as follows table 1:

[0051]

[0052]

[0053] Table 1

[0054] Preparation process: according to the amounts shown in Table 1, respectively weigh vaseline, lanolin, stearic acid and liquid paraffin to mix to obtain an oil phase; weigh SE-11, glycerin and water, and mix them evenly to obtain an aqueous phase; weigh Carbomer 980, and slowly added to the high-speed stirring water, the gel phase was obtained after the dissolution was complete; α-mangostin was weighed and mixed with methylparaben, and the mixture was dissolved in ethanol.

[0055] Heat the oil phase and water at the same time until the oil phase is completely dissolved (about 80°C), add the water phase to the oil phase under isothermal conditions and keep grinding and stop heating. After grinding to close to room temperature, add the gel phase and continue grinding , adding an ethanol solution in which α-mangostin and methylparaben we...

Embodiment 2

[0057] This embodiment is sample 2 under one of the implementation modes of the present invention, and its components are as follows in Table 2:

[0058]

[0059] Table 2

[0060] Preparation process: According to the dosage shown in Table 2, respectively weigh vaseline, lanolin, stearic acid and liquid paraffin and mix to obtain an oil phase; weigh SE-11, glycerin and water, and mix them evenly to obtain an aqueous phase; weigh Carbomer 980, and slowly added to the high-speed stirring water, the gel phase was obtained after the dissolution was complete; α-mangostin was weighed and mixed with methylparaben, and the mixture was dissolved in ethanol.

[0061] Heat the oil phase and water at the same time until the oil phase is completely dissolved (about 80°C), add the water phase to the oil phase under isothermal conditions and keep grinding and stop heating. After grinding to close to room temperature, add the gel phase and continue grinding , add the ethanol solution that...

Embodiment 3

[0063] This embodiment is sample 3, and it is compared with embodiment 2, does not contain α-mangostin, and component is as follows table 3:

[0064]

[0065] table 3

[0066] Preparation process: According to the dosage shown in Table 3, respectively weigh vaseline, lanolin, stearic acid and liquid paraffin and mix to obtain the oil phase; weigh SE-11, glycerin and water, and mix them evenly to obtain the water phase; weigh Carbomer 980, and slowly added to the high-speed stirring water, the gel phase was obtained after complete dissolution; weighed methyl paraben and dissolved in ethanol.

[0067] Heat the oil phase and water at the same time until the oil phase is completely dissolved (about 80°C), add the water phase to the oil phase under isothermal conditions and keep grinding and stop heating. After grinding to close to room temperature, add the gel phase and continue grinding , adding an ethanol solution in which methylparaben was dissolved, and grinding evenly, an...

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Abstract

The present invention provides a cosmetic composition containing α-mangostin and its application. It has been verified that, on the one hand, α-mangostin has ultraviolet absorption ability, has strong absorption in the UVB region of 290-320nm, and has weak absorption in the UVA region of 320-400nm, which can complement other sunscreen agents. On the other hand, α-mangostin Mangostin acts as a sunscreen synergist for some sunscreen agents, so it can be widely used in cosmetics, especially in sunscreen compositions.

Description

technical field [0001] The invention relates to a cosmetic composition, in particular to a sunscreen or whitening cosmetic composition, and belongs to the technical field of cosmetics. Background technique [0002] As we all know, excessive ultraviolet radiation can damage the human immune system, accelerate skin aging, lead to the occurrence of various skin diseases, and even cause skin cancer. Ultraviolet radiation is one of the main factors causing skin aging. According to the wavelength range, ultraviolet rays can be divided into UVC (100-290nm), UVB (290-320nm) and UVA (320-400nm) parts. UVC can be completely absorbed by the ozone layer; UVB has high energy, and most of it is absorbed by the dermis of the skin. Long-term exposure will cause erythema, inflammation, skin aging, and even skin cancer; although the energy of UVA is low, the energy reaching the human body accounts for the total energy of ultraviolet rays. More than 98% of UVA has a slow effect on the skin. A...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A61K8/40A61K8/37A61K8/35A61K8/29A61K8/27A61Q17/04A61Q19/02
CPCA61K8/27A61K8/29A61K8/35A61K8/37A61K8/40A61K8/498A61Q17/04A61Q19/02A61K2800/522A61Q19/08A61K2800/591
Inventor 王进欣张婷婷
Owner 南京美竹医药科技有限公司
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