Wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release

A wearable, high blood pressure technology, which is applied in the fields of drug equipment, diagnosis, medical science, etc., can solve the problems of inaccurate drug dosage, adjustment of dosage, poor detection accuracy, etc., and achieve real-time and accurate blood pressure monitoring, realize blood pressure, Achieving a controlled release effect

Pending Publication Date: 2018-10-19
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, there are devices for high-frequency blood pressure detection using photoelectric or mechanical sensing methods, but there are still major problems, such as poor detection accuracy, which can only reflect the trend of overall blood pressure changes, and cannot achieve the same accuracy as mercury sphygmomanometers. The clinical accuracy requirement of negative 5mmHg error, or the accuracy can be met, but the wearing method and use conditions are more stringent and the price is high
In terms of drug delivery meth

Method used

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  • Wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release
  • Wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release
  • Wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0083] Hypertensive patient A, male, 40 years old, the blood pressure measured in the clinic was 150mmHg systolic and 95mmHg diastolic, and was diagnosed as mild (grade 1) hypertension. The antihypertensive drug is captopril, and the transdermal dosage is 50mg / day. The single-chip microneedle contains 100mg captopril, which meets the dosage required for 48h continuous blood pressure regulation. The blood pressure monitoring device collects blood pressure every 1 minute, sets the systolic blood pressure to 135mmHg, and diastolic blood pressure to 90mmHg as the threshold value. When the blood pressure exceeds any of these values, an instruction is sent to the drug delivery device to release 5mg of the drug, and the blood pressure is collected every 30s within 5 minutes. value. After 5 minutes, if the drop in systolic blood pressure is greater than or equal to 5mmHg, and the drop in diastolic blood pressure is greater than or equal to 3mmHg, it is judged that blood pressure contr...

Embodiment 2

[0085] Hypertensive patient B, female, 50 years old, the blood pressure measured in the clinic was 170mmHg systolic and 105mmHg diastolic, and was diagnosed as moderate (grade 2) hypertension. The antihypertensive drugs were captopril and nifedipine, and the transdermal dosages were 100mg / day and 30mg / day, respectively. The single-chip microneedles contain 200mg captopril and 60mg nifedipine. The blood pressure monitoring device collects blood pressure every 30s, sets systolic blood pressure 135mmHg, diastolic blood pressure 90mmHg as the threshold, when the blood pressure exceeds any of these values, sends instructions to the drug delivery device to release 10mg of captopril and 3mg of nifedipine, and in 3 The blood pressure value is collected every 20s within 1 minute. After 3 minutes, if the systolic blood pressure drops greater than or equal to 5mmHg, and the diastolic blood pressure drops greater than or equal to 3mmHg, it is judged that the blood pressure regulation is ...

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Abstract

The inVention belongs to the technical field of products for diagnosing and treating high blood pressure, in particular to a wearable high blood pressure real-time diagnosis and treatment integrated system with controllable drug release. The system comprises a wearable blood pressure monitoring deVice and a micro-needle controllable drug doser, the wearable blood pressure monitoring deVice comprises a hand ring worn on a wrist part, a graphene pressure sensor, a signal processing module, a data storage module, a data transmission module and a battery are arranged on the hand ring; the micro-needle controllable drug doser comprises an arm belt worn on an arm part, a high blood pressure drug micro needle , an instruction receiVing and controllable release module and a micro-needle storage module arranged on the arm belt. The system has the adVantages of conVenient use, accurate diagnosis and treatment, and can carry out immediate and accurate dose according to abnormal conditions of blood pressure while monitoring blood pressure, so as to realize timely and effectiVe control of blood pressure and effectiVely improVe the effect of high blood pressure treatment.

Description

technical field [0001] The invention belongs to the technical field of products for diagnosing and treating hypertension, and in particular relates to a wearable integrated system for real-time diagnosis and treatment of hypertension with controllable drug release. Background technique [0002] In the prior art, with the gradual acceleration of the pace of modern life and the increase in people's life pressure year by year, the number of hypertensive patients shows an obvious upward trend, and hypertension is a disease characterized by elevated arterial pressure, which can Systemic symptoms accompanied by functional or organic changes in the heart, blood vessels, brain and kidneys, etc., can lead to stroke, myocardial infarction, heart failure, hemangioma, renal failure and other diseases or even death in severe cases. major public health problem worldwide. [0003] Hypertension is a chronic disease, and it is very difficult to completely cure it. At present, the common cli...

Claims

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Application Information

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IPC IPC(8): A61M37/00A61B5/021
CPCA61M37/0015A61B5/021A61B5/681A61M2230/30A61M2037/0061A61M2037/0023A61M2230/005A61M2037/0046A61B5/02133A61B5/4839
Inventor 陶军刘繁茂李琰林志鸿余冰波谢曦
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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