Application of salidroside to preparation of Parkin protein agonist drug

A technology of salidroside and agonist, which is applied in the field of biomedicine and can solve the problems that the application of salidroside is not disclosed

Inactive Publication Date: 2018-11-06
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But other applications of salidroside are not disclosed

Method used

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  • Application of salidroside to preparation of Parkin protein agonist drug
  • Application of salidroside to preparation of Parkin protein agonist drug
  • Application of salidroside to preparation of Parkin protein agonist drug

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Embodiment Construction

[0027] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0028] All surgical interventions, treatments and postoperative animal care procedures in the present invention were strictly implemented in accordance with the regulations of the Animal Ethics Committee of Wenzhou Medical University (wydw2014-0129).

[0029] experimental method

[0030] Nucleus pulposus (NP) cell culture

[0031] Extract NP cells from healthy SD rats (20 males, 100-150g body weight) at 37°C and 5% CO 2 Conditions, cultured in DMEM medium containing 10% fetal bovine serum (FBS; Gibco, Waltham, MA, USA) and 1% penicillin / streptomycin (Invitrogen) for three weeks, except that primary cells were replaced in the first Before the medium was cultured for 6.7±1.4 days, the medium of the remaining cells was changed twice a week. Second generation cells were used in the experiments. Drug treatment: 10nM concentration of TNF-α was added to th...

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Abstract

The invention specifically discloses new application of salidroside, in particularly application of salidroside to the preparation of a Parkin protein agonist drug. By promoting the expression of parkin protein, salidroside, as a Parkin protein agonist, promotes mitochondrial autophagy and mitochondrial homeostasis, inhibiting apoptosis, and thereby the salidroside can be used for treating the neurodegenerative disease and the degenerative disease of the musculoskeletal system.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of salidroside in the preparation of Parkin protein agonist drugs. Background technique [0002] Parkin protein can play multiple functions in organisms through autophagy-lysosome pathway and ubiquitin-proteasome pathway. In the autophagy-lysosome system (ALS), parkin protein can protect cells and inhibit apoptosis by promoting mitophagy, clearing damaged mitochondria, and excessive oxygen free radicals in organisms. In the ubiquitin-proteasome (UPS), parkin protein acts as an E3 ubiquitin ligase, which can bind to substrate proteins and promote their degradation, maintaining intracellular protein homeostasis. Through the UPS pathway, parkin protein can participate in the regulation of multiple processes such as gene transcription and protein degradation in vivo. [0003] Decreased expression or inhibited activity of Parkin protein is the main pathological b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P25/28A61P19/08A61P21/00
CPCA61K31/7032A61P19/08A61P21/00A61P25/28
Inventor 张小磊章增杰丁远哲王向阳
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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