Capsule shell capable of delaying ageing of capsules and preparation method of capsule shell

Abstract

The invention belongs to the technical field of colloid chemistry and discloses a capsule shell capable of delaying ageing of capsules and a preparation method of the capsule shell. The capsule shellis prepared by adopting modified gelatin. The weight ratio of glycerol to dry single terminated PEG-CHO modified gelatin is (0.4 to 0.6) to 1.0; and the ratio of water to the dry single terminated PEG-CHO modified gelatin is (1.0 to 1.6) to 1.0. After various types of aldehyde react with the gelatin, the quantity of amino in the gelatin can be reduced through an aldehyde group; a research for thechanges of a swelling speed of the gelatin in the water finds out that the gelatin has a relatively high swelling speed through the aldehyde group and ageing reaction of the gelatin is hopefully inhibited; and the method is a relatively ideal method for delaying the ageing of the gelatin. Single terminated PEG-CHO can be used for modifying a gelatin molecule structure and an obtained product is modified gelatin; and PEG400 is added into a capsule shell formula, the flexibility of the capsule shell is modified and a final formula of a modified gelatin capsule shell is determined.

Description

technical field [0001] The invention belongs to the technical field of soft capsules, in particular to a capsule shell for delaying the aging of soft capsules and a preparation method thereof. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: The soft capsules on the market are mainly gelatin soft capsules, and gelatin is the product of gentle fracture of collagen, which is a kind of fibrin. Most commercially available gelatin collagens are extracted from porcine and bovine connective and hard aggregate tissues, which limits the use of gelatin. There are quite a few people in the world who cannot eat pig products, and gelatin products do not indicate their animal origin, so the use of gelatin is restricted in some people. In recent years, due to frequent outbreaks of zoonotic epidemics, the safety of gelatin has been greatly reduced. The soft capsule shell made of gelatin contains amino groups and is prone to ...

AI Technical Summary

Problems solved by technology

[0004] (1) At present, most gelatin collagens in gelatin soft capsules are extracted from connective tissue and hard aggregate tissue of pigs and cattle, which limits the use of some people

[0005] (2) The safety of gelatin is greatly compromised due to frequent outbreaks of influenza in zoonotic diseases

[0006] (3) Soft capsule shells made of gelatin are prone to aging, which affects dissolution. In addition, gelatin is also greatly affected by temperature, and aging is very fast when stored above 40 °C

However, due to the large consumption of amino groups in the above treatment, the hydrophilicity of the soft capsule is reduced, and the swelling rate and disintegration rate are affected.

[0012] In short, the problem of gelatin soft capsule aging has seriously affected the development of the soft capsule industry, and it has to be solved

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