A kind of preparation method and application of ph-responsive high-strength conductive hydrogel

Abstract

The present invention relates to a preparation method and application of a pH-responsive high-strength conductive hydrogel in the field of biotechnology. The preparation method includes preparing a 5-20wt% γ-polyglutamic acid aqueous solution to obtain a first reaction solution; then add γ‑(2,3‑glycidoxy) propyltrimethoxysilane, and stir well to obtain the second reaction solution; add hydrolyzed tetraethyl orthosilicate to the second reaction solution to adjust water The degree of cross-linking of the gel can be used to obtain a pH-responsive high-strength conductive hydrogel. The hydrogel prepared by the invention has high water absorption, adjustable mechanical properties, good drug loading capacity, pH-regulated drug release behavior, good electrical conductivity and biocompatibility. The preparation time of the hydrogel is short, the method is simple, and the energy consumption is low, and it can be widely used in applications such as drug carriers, wound dressings, and biosensing.

Description

A kind of preparation method and use of pH-responsive high-strength conductive hydrogel technical field The present invention relates to a kind of high molecular biomedical material, particularly a kind of preparation method of conductive hydrogel and the same use. Background technique Polyglutamic acid (γ-PGA), it is a water-soluble, biodegradable, and non-toxic, using microbial fermentation Biopolymers prepared by the method. Cross-linking with three-dimensional network can be formed by cross-linking methods such as chemical cross-linking agents and radiation irradiation. γ‑PGA hydrogel materials. The γ‑PGA hydrogel material has good biocompatibility, water retention and electrical conductivity, and can be used as a Pharmaceutical carriers, wound dressings, cosmetics, biosensing, etc. Chinese invention patent CN101891954A discloses a kind of preparation method of polyglutamic acid hydrogel, its publication date: 20101124, the method uses polyglutamic acid as ...

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Problems solved by technology

Its disadvantages are: the amount of cross-linking agent is large, resulting in waste, and ethylene glycol diglycidyl ether has certain toxicity to the human body, and the reaction time is long, so it is necessary to pay attention to the reaction at intervals during the reaction process. The change of pH value, the hydrogel obtained by the reaction also needs to be swollen, dialyzed and freeze-dried. The process is relatively cumbersome, and there are obvious shortcomings in the mass preparation of materials.

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