Marine traditional-Chinese-medicine bruguiear gymnorrhiza leaf extract, preparation method and application thereof for resisting pancreatic cancer

A technology of extract and oleifera, applied in the field of pancreatic cancer treatment, can solve problems such as pancreatic cancer that has not been seen with oleifera extract

Active Publication Date: 2018-12-07
GUANGXI UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the use of olive leaf extract in the treatment of pancreatic cancer

Method used

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  • Marine traditional-Chinese-medicine bruguiear gymnorrhiza leaf extract, preparation method and application thereof for resisting pancreatic cancer
  • Marine traditional-Chinese-medicine bruguiear gymnorrhiza leaf extract, preparation method and application thereof for resisting pancreatic cancer
  • Marine traditional-Chinese-medicine bruguiear gymnorrhiza leaf extract, preparation method and application thereof for resisting pancreatic cancer

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] 1. The effect of olive leaf extract on the proliferation of human pancreatic cancer cells SW1990

[0020] 1. Materials

[0021] 1.1 Medicinal materials:

[0022] Lavender leaves, batch number 20160710, were collected from the mangrove reserve at the mouth of the Beilun River in Fangchenggang. According to the identification of Professor Li Yonghua from Guangxi University of Traditional Chinese Medicine, the leaves of Lavender are the dried leaves of Bruguiera gymnorrhiza (L.) Savigny.

[0023] 1.2 Cell lines

[0024] Human pancreatic cancer cell line: SW1990.

[0025] 1.3 Reagents

[0026] L15 incomplete medium was purchased from Jiangsu KGI Biotechnology Co., Ltd. (batch number: 20171026); 0.25% EDTA-containing trypsin was purchased from Gibco, USA (batch number: 1895789); fetal bovine serum was purchased from Gibco, USA ( Lot No. 1660517); Paclitaxel (PTX): purchased from Invitrogen, USA (Product No.: sp8020); Cell Proliferation Detection Kit (MTS): purchased fro...

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Abstract

The invention discloses an application of a marine traditional-Chinese-medicine bruguiear gymnorrhiza leaf extract in the aspect of preparing medicines for treating pancreatic cancer. Discovered fromresults, bruguiear gymnorrhiza leaf ethanol extract, petroleum ether extract and ethyl acetate extract have obvious inhibition actions respectively for pancreatic cancer cells SW1990, wherein the ethyl acetate part of the bruguiear gymnorrhiza leaf has most obvious effect for inhibiting multiplication of the pancreatic cancer SW1990, can inhibit migration and invasion of the pancreatic cancer SW1990 obviously, the effect for inhibiting multiplication is in a positive correlation to time and concentration, which prompts that the extract of the ethyl acetate part of the bruguiear gymnorrhiza leaf has exact effect for resisting the pancreatic cancer SW1990. The application disclosed by the invention has the beneficial effects that the effect and the molecular mechanism for resisting the pancreatic cancer of the antitumor active part of the bruguiear gymnorrhiza leaf are illuminated, scientific basis is provided for fully developing the medicinal value of the bruguiear gymnorrhiza leaf resource, a new path is opened up for using traditional Chinese medicines to treat the pancreatic cancer, and reference is provided for clinical application of the bruguiear gymnorrhiza for resisting thecancer.

Description

technical field [0001] The invention belongs to the technical field of pancreatic cancer treatment, and in particular relates to a marine traditional Chinese medicine Lavender leaf extract, a preparation method thereof and an anti-pancreatic cancer application. Background technique [0002] Pancreatic cancer is a digestive system tumor with a very high degree of malignancy. The incidence of pancreatic cancer in the world is rapidly trending. According to incomplete statistics, the five-year survival rate does not exceed 5%. The occurrence and development of pancreatic cancer are closely related to genetic background, environmental factors, underlying diseases and living habits. At present, it is believed that smoking, obesity, diabetes, chronic pancreatitis and family history of pancreatic cancer are all related to the pathogenesis of pancreatic cancer. [0003] Modern clinical treatment methods for pancreatic cancer include: traditional radiotherapy and chemotherapy, surge...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00A61P35/04A61K127/00
CPCA61P35/00A61P35/04A61K36/185A61K2236/333A61K2236/35A61K2236/33A61K2236/15A61K2236/39A61K2236/51
Inventor 邓家刚谢蕾卉杜正彩侯小涛郝二伟谢金玲
Owner GUANGXI UNIV OF CHINESE MEDICINE
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