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Application of imidazopyridine derivative

A technology of imidazopyridine and derivatives, which is applied in the field of compound application, can solve problems such as complex and diverse components, incomplete treatment, and large side effects, and achieve the effects of improving antibacterial efficiency, preventing skin allergies, and preventing recurrence

Inactive Publication Date: 2018-12-21
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional Chinese medicine formulas have problems such as complex and diverse components, high cost, and poor efficacy.
[0005] In summary, the Chinese and Western medicines currently used for the prevention or treatment of tinea manus and pedis disease have the problems of large side effects, poor efficacy and incomplete treatment.

Method used

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  • Application of imidazopyridine derivative
  • Application of imidazopyridine derivative
  • Application of imidazopyridine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1, a kind of tinea pedis medicament

[0036] The tinea pedis medicament comprises the following components and their mass percentages:

[0037] Moisturizer 50%, surfactant 4%, emulsifier 2%, thickener 3%, bacteriostat 25%, antioxidant 1.5%, pH regulator 1.5%, vitamin E 1%, deionized water 12%; The antibacterial agent is composed of honeysuckle essential oil and imidazopyridine derivatives described in formula I in a mass ratio of 7:6.

[0038] The moisturizing agent is composed of dipropylene glycol and butylene glycol in a mass ratio of 5:4; the surfactant is quaternary ammonium-15; the emulsifier is shea butter; the thickener is hydroxyethyl cellulose The antioxidant is composed of squalane and grape seed oil in a mass ratio of 5:4; the pH regulator is citric acid.

[0039] The preparation method of described tinea manus and pedis medicament, comprises the steps:

[0040] S1. Dissolve the humectant, surfactant, thickener and antioxidant in deionized wate...

Embodiment 2

[0043] Embodiment 2, a kind of tinea pedis medicament

[0044] The tinea pedis medicament comprises the following components and their mass percentages:

[0045]Moisturizer 42%, surfactant 1%, emulsifier 0.5%, thickener 1%, bacteriostat 16%, antioxidant 0.5%, pH regulator 0.5%, vitamin E 0.5%, deionized water 38%; The antibacterial agent is composed of honeysuckle essential oil and imidazopyridine derivatives described in formula (I) in a mass ratio of 7:3.

[0046] The moisturizing agent is composed of dipropylene glycol and butylene glycol in a mass ratio of 5:2; the surfactant is quaternary ammonium-15; the emulsifier is shea butter; the thickener is hydroxyethyl cellulose The antioxidant is composed of squalane and grape seed oil in a mass ratio of 5:1; the pH regulator is citric acid.

[0047] The preparation method of described tinea manus and pedis medicament, comprises the steps:

[0048] S1. Dissolve humectant, surfactant, thickener and antioxidant in deionized wat...

Embodiment 3

[0051] Embodiment 3, a kind of tinea pedis medicament

[0052] The tinea pedis medicament comprises the following components and their mass percentages:

[0053] Moisturizing agent 48%, surfactant 3%, emulsifier 0.9%, thickener 2.2%, bacteriostat 17%, antioxidant 1.2%, pH regulator 1.1%, vitamin E 0.6%, deionized water 26%; The antibacterial agent is composed of honeysuckle essential oil and imidazopyridine derivatives described in formula I in a mass ratio of 7:4.

[0054] The moisturizing agent is composed of dipropylene glycol and butylene glycol in a mass ratio of 5:4; the surfactant is quaternary ammonium-15; the emulsifier is shea butter; the thickener is hydroxyethyl cellulose The antioxidant is composed of squalane and grape seed oil in a mass ratio of 5:3; the pH regulator is citric acid.

[0055] The preparation method of described tinea manus and pedis medicament, comprises the steps:

[0056] S1. Stir the humectant, surfactant, thickener and antioxidant in deion...

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Abstract

The invention belongs to the field of application of organic compounds and particularly relates to the application of an imidazopyridine derivative. The invention provides the application of the imidazopyridine derivative in a formula I in preparing bactericidal and bacteriostatic agents (The formula is shown in the description). The imidazopyridine derivative provided by the invention is appliedto medicaments for treating tinea manus and tinea pedis, wherein the medicaments for treating the tinea manus and tinea pedis have multiple good effects of sterilizing, caring skin, inhibiting bacteria and diminishing inflammation; meanwhile, an antibacterial hand sanitizer provided by the invention also has the advantages of good antiallergic effect, capability of preventing relapse of tinea manus and tinea pedis diseseas, high safety and good application prospect.

Description

technical field [0001] The invention belongs to the field of application of compounds, in particular to the application of imidazopyridine derivatives. Background technique [0002] Imidazolopyridine derivatives are artificially synthesized compounds, which are mainly used as intermediates and active ingredients of antihypertensive and anticancer drugs. Studies have shown that such compounds also have a strong effect of eliminating bacteria, fungi and viruses. Therefore, it is also used in anti-inflammatory drugs. Among them, Chinese patent application CN1646530A discloses a series of nitrosylated imidazopyridines, which have gastric secretion inhibition, anti-inflammatory and antibacterial properties. [0003] Tinea manus and pedis is a disease caused by pathogenic fungi, which is an infection caused by dermatophytes invading the fingers, between the toes, and the palms and soles. The pathogens are mainly Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61K36/355A61K36/287A61P17/00A61P31/04A61P31/06A61P31/10
CPCA61K31/437A61K9/0014A61K36/287A61K36/355A61K47/10A61K47/12A61K47/44A61P17/00A61P31/04A61P31/10A61K2300/00
Inventor 曹华陈伟鑫
Owner GUANGDONG PHARMA UNIV
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