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2,2-dimethylbenzopyran derivative and preparation method and use thereof

A technology of dimethylbenzopyrans and benzopyrans, which is applied in the field of 2,2-dimethylbenzopyran derivatives and their preparation, and can solve problems such as special action sites and complex pathogenesis

Active Publication Date: 2018-12-28
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to its complex pathogenesis and special site of action, there is no safe and effective drug for clinical treatment.

Method used

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  • 2,2-dimethylbenzopyran derivative and preparation method and use thereof
  • 2,2-dimethylbenzopyran derivative and preparation method and use thereof
  • 2,2-dimethylbenzopyran derivative and preparation method and use thereof

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Abstract

The invention belongs to the technical field of medicines, and discloses a 2,2-dimethylbenzopyran derivative and a preparation method and use of the 2,2-dimethylbenzopyran derivative. The derivative and pharmaceutically acceptable salt of the derivative have the structural formulae shown in the description, wherein Ar<1>, Ar<2>, X, Y and R1 are as described in the claims and the description. The preparation methods of the derivative and the pharmaceutically acceptable salt of the derivative comprise the following steps: the formula (I) is obtained by mainly taking acetaminophen as a raw material, and subjected to the reactions of Williamson ether formation, cyclization, hydrolysis, amide formation and the like; the formula II is obtained by mainly taking p-hydroxybenzaldehyde as a raw material, and subjected to the reactions of the Williamson ether formation, cyclization, Knoevenagel condensation, amide formation and the like. The derivative and the pharmaceutically acceptable salt ofthe derivative disclosed by the invention can be used for preparing neuroprotective agents and have better neuroprotective effects on ischemic stroke.

Description

technical field The invention belongs to the technical field of medicine, and relates to a class of 2,2-dimethylbenzopyran derivatives and a preparation method and application thereof. Background technique Cerebrovascular Disease (Cerebrovascular Disease) is a group of diseases caused by brain tissue damage caused by blood circulation disorders in the brain. Clinically, acute cerebrovascular disease is the most common disease, commonly known as "stroke" and "stroke", and its clinical manifestations are hemiplegia and speech impairment. Acute cerebrovascular diseases are generally divided into two types: ischemic and hemorrhagic, among which ischemic is the most common cerebrovascular disease. Ischemic cerebrovascular disease, also known as ischemic stroke, is one of the main diseases that cause disability and death in middle-aged and elderly people. It has the characteristics of high incidence, high recurrence rate, high disability rate, and high mortality rate. In 2011, s...

Claims

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Application Information

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IPC IPC(8): C07D311/04C07D407/12C07D409/12A61K31/352A61K31/496A61K31/381A61K31/36A61P9/10A61P25/28
CPCA61P9/10A61P25/28C07D311/04C07D407/12C07D409/12
Inventor 陈国良杨静玉杜芳瑜周启璠方武宏王立辉吴春福
Owner SHENYANG PHARMA UNIVERSITY
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