High performance micro-mixer used in ultra-high performance liquid chromatography analyzer

A chromatographic analyzer and ultra-high performance liquid phase technology, applied in the field of micro-mixers, can solve the problems of unstable mixing performance and high cost of micro-mixers, and achieve the effects of improving mixing efficiency, prolonging working life and improving stability

Active Publication Date: 2019-01-11
BEIJING UNIV OF TECH +1
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Problems solved by technology

[0007] The present invention mainly aims at the instable mixing performance and high cost of micro-mixers in UPLC, and provides a new type of UPLC micro-mixer with simple structure, high mixing efficiency and stable performance. The micro-mixer can be applied to existing In some ultra-high performance liquid chromatography analyzers, improve the accuracy of drug analysis and environmental monitoring

Method used

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  • High performance micro-mixer used in ultra-high performance liquid chromatography analyzer
  • High performance micro-mixer used in ultra-high performance liquid chromatography analyzer
  • High performance micro-mixer used in ultra-high performance liquid chromatography analyzer

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Embodiment Construction

[0026] Since the present invention is based on a micro-scale mixer, the requirements for processing methods are relatively high, and the present invention needs to work in a high-pressure environment, and the traditional micro-mixer manufacturing process cannot meet the requirements of the present invention. Based on the above considerations, A high-performance micro-mixer used in ultra-high performance liquid chromatography analyzers of the present invention is processed and manufactured using the additive manufacturing technology of laser metal powder sintering and 3D printing.

[0027] Two different solvents flow into the mixing chamber at equal speed from the two inlet channels respectively, and complete the mixing while flowing in a square wave path in the mixing chamber, and finally the mixed solvent flows out from the outlet channel on the right to complete the mixing.

[0028] The two solvents are fully mixed in the mixing chamber by means of molecular diffusion and con...

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Abstract

The invention discloses a high performance micro-mixer used in an ultra-high performance liquid chromatography analyzer, and belongs to the field of high grade biochemistry analysis and fluid micro mixing in micro-complete analysis systems. The high performance micro-mixer comprises two inlet channels, a mixing chamber, twelve blocking plates which are distributed in an up-down staggered manner, and an outlet channel; the blocking plates are capable of enhancing the convection effect in solvent flowing, so that it is convenient for forming of a vortex zone; and in addition, the staggered blocking plates are capable of realizing flow of mixed solvent in the mixing chamber in a square wave patter path, and vortex is easily formed at corners, the existing of vortex is capable of breaking laminar flow state of solvent in flowing, and delaying diffusion path of mixed solvent in the mixing chamber, the mixing performance of the high performance micro-mixer is improved obviously, and the precision of the ultra-high performance liquid chromatography analyzer is increased further.

Description

technical field [0001] The invention relates to a micro-mixer in an ultra-high performance liquid chromatography analyzer, which has higher mixing performance. The invention belongs to the field of fluid micro-mixing in high-end biochemical analysis and micro-total analysis systems. Background technique [0002] Ultra-high performance liquid chromatography (UPLC) is an important means to solve problems such as drug analysis, biochemical analysis, blood testing and environmental testing, and plays an important role in improving drug treatment capabilities and enhancing disease analysis capabilities. The instrument is rapidly used in food safety, environment, pharmaceuticals, scientific research and other fields. Despite the rapid development of ultra-high performance liquid chromatography, the high-precision reagent delivery system in it lacks a matching supplier and a complete supply chain solution, and its flow accuracy, accuracy, pressure pulsation and system delay volume...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F5/06B01F13/00G01N30/02
CPCG01N30/02B01F25/421B01F33/305
Inventor 刘赵淼赵晟王文凯逄燕殷参徐迎丽
Owner BEIJING UNIV OF TECH
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