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Use of ledol in treating ovarian cancer

A technology of trumpet alcohol and ovarian cancer, applied in the field of medicine, can solve problems such as death and evolution

Inactive Publication Date: 2019-01-18
淮安培元基因科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although complete remission can be achieved after initial surgery and chemotherapy, most patients with advanced disease will still relapse within 2 to 3 years, and eventually become resistant to chemotherapy and die

Method used

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  • Use of ledol in treating ovarian cancer
  • Use of ledol in treating ovarian cancer

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0016] 1. Experimental materials

[0017] The structural formula of the test compound is as figure 1 As shown, including trumpetene, trumpet alcohol, cinnamonolide, isoartemisinic acid, 7-armentene-6-one and 4-arrene, the standard products are purchased or self-made, and the purity is ≥98%.

[0018] Human ovarian cancer SKOV3 cells and human cervical cancer Hela cells were purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences.

[0019] DMEM / F12 medium, high-glucose DMEM medium, and fetal bovine serum were purchased from GIBCO.

[0020] Tetramethylazolazolium blue (MTT) and DMSO were purchased from SIGMA.

[0021] Double antibody solution and trypsin were purchased from Hyclone Company, USA.

[0022] 2. Experimental method

[0023] 1. Cell culture

[002...

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Abstract

The invention discloses use of ledol in treating ovarian cancer. The present inventors have found that cinnabarinol, isoamyl sulphonic acid, 7-seriesene ketone, and ketone orange have excellent proliferation inhibition effects on human ovarian cancer SKOV3 cells and human cervical cancer Hela cells; Although the chemical structure is a dehydration product of tallow tea alcohol, the chemical structure is similar, but the proliferation inhibitory activity of human ovarian cancer SKOV3 cells and human cervical cancer Hela cells is quite different, among which: trumpet tea is on the cervical cervix. The proliferation inhibition effect of cancer Hela cells was obvious, and the inhibition of proliferation of human ovarian cancer SKOV3 cells was not obvious, while tallow tea alcohol inhibited theproliferation of human ovarian cancer SKOV3 cells, and inhibited the proliferation of human cervical cancer Hela cells. Terpene catechin, trumpet tea alcohol, cinnabarinol, isoamyl sulphonic acid, 7-mannitol ketone and 4 citron are all used for the treatment of gynecological tumors.

Description

technical field [0001] The invention belongs to the field of medicine, relates to gynecology, and specifically relates to an application of trumpet alcohol for treating ovarian cancer. Background technique [0002] Gynecological tumor is a common and frequently-occurring disease that seriously threatens women's health, and can be divided into benign and malignant. Common gynecological benign tumors include ovarian benign tumors, ovarian tumor-like lesions (simple ovarian cysts and ovarian chocolate cysts, etc.), pelvic inflammatory masses, adenomyosis, and uterine fibroids. The specific methods include surgery, drugs, intervention, etc., among which surgery is the main treatment method, but its damage to ovarian function has been in recent years. has been gradually paid attention to. Traditional Chinese medicine treatment of gynecological benign tumors can control and reduce the tumor size for patients who do not meet the surgical indications, so as to avoid surgical traum...

Claims

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Application Information

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IPC IPC(8): A61K31/045A61K31/015A61K31/122A61K31/19A61K31/365A61P35/00
CPCA61K31/045A61K31/015A61K31/122A61K31/19A61K31/365A61P35/00
Inventor 张长林杨佳
Owner 淮安培元基因科技有限公司
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