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Probe compound for detecting fluoride ions and detection method of probe compound

A compound, fluoride ion technology, applied in the field of anion fluorescence analysis and detection, can solve problems such as narrow response range, low sensitivity, and quantum efficiency is easily affected by the environment, and achieves the effect of improving sensitivity and eliminating systematic errors.

Active Publication Date: 2019-01-25
DALIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the fluoride ion fluorescent probes reported so far are fluorescence-enhancing probes. [1-7] , the quantum efficiency of this type of probe is easily affected by the environment, so it has certain limitations in practical application, while the ratiometric fluorescent probe can avoid the influence of the detection environment and realize the quantitative detection of the dynamic change process of fluorine ions. There are few reports on the detection of fluoride ion content by ratiometric fluorescent probes [8,9] , and the reported probes of this type have some defects, such as low sensitivity [8] , narrow response range [9] etc., so it is very important to develop new ratiometric fluorescent probes for the determination of fluoride ions

Method used

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  • Probe compound for detecting fluoride ions and detection method of probe compound
  • Probe compound for detecting fluoride ions and detection method of probe compound
  • Probe compound for detecting fluoride ions and detection method of probe compound

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Dissolve the probe compound N-3-hydroxyl-4-2'-benzothiazolebenzene-3,5-dibenzyloxybenzamide in DMSO to make a concentration of 1×10 -3 mol / L solution A, take 30 μL solution A and dissolve it in the sample cell containing 3mL acetonitrile, mix the solution evenly to obtain the concentration of the probe compound as 1×10 -5mol / L mixture B. Prepare acetonitrile solutions containing different anions, namely tetrabutylammonium fluoride acetonitrile solution, tetrabutylammonium dihydrogenphosphate acetonitrile solution, tetrabutylammonium hydrogensulfate acetonitrile solution, tetrabutylammonium acetate acetonitrile solution and tetrabutylammonium chloride Acetonitrile solution of ammonium fluoride, add above-mentioned five kinds of solutions respectively in mixed solution B, make the concentration of tetrabutylammonium fluoride after adding be 200 times of probe compound, the concentration of other four kinds of tetrabutylammonium fluoride is probe compound 1000 times of th...

Embodiment 2

[0029] Dissolve the probe compound N-3-hydroxyl-4-2'-benzothiazolebenzene-3,5-dibenzyloxybenzamide in DMSO to make a concentration of 1×10 -3 mol / L solution A, take 30 μL solution A and dissolve it in the sample cell containing 3mL acetonitrile, mix the solution evenly to obtain the concentration of the probe compound as 1×10 -5 mol / L mixed solution B, gradually add the acetonitrile solution of tetrabutylammonium fluoride dropwise to the mixed solution B, so that the concentration of tetrabutylammonium fluoride after adding is respectively 2, 5, 10, 50 of the probe compound , 80, 100, 150, 200, 230 times, measure respectively the fluorescence spectrum (such as figure 2 ). Along with the increase of fluoride ion concentration, the fluorescent peak intensity at 500nm on the fluorescence spectrum weakens gradually, and a new peak appears at 450nm, and the fluorescent peak intensity strengthens gradually, with the ratio of 450nm and 500nm fluorescent intensity (I 450 / I 500 ) ...

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Abstract

Disclosed are a probe compound for detecting fluoride ions and a detection method of the probe compound. The invention relates to the fluorescent probe compound N-3-hydroxy-4-2'-benzothiazole benzene-3,5-diphenyl methoxybenzamide for detecting the fluoride ions and the method for detecting the fluoride ions with the compound as a ratiometric fluorescent probe. The fluoride ion fluorescent probe compound has a wide detection range, and the response range is 2*10<-5>-2*10<-3> mol / L; the selectivity is good, and acetate radicals, dihydrogen phosphate radicals, hydrogen sulfate radicals and chloride ions have no obvious interference with the detection of the concentration of the fluoride ions. The probe compound for detecting the fluoride ions and the detection method of the probe compound aresuitable for the detection of the fluoride ions in the fields of biochemistry, environmental chemistry and the like.

Description

technical field [0001] The invention belongs to the technical field of anion fluorescence analysis and detection, and in particular relates to a - ) a fluorescent probe compound N-3-hydroxyl-4-2'-benzothiazolylbenzene-3,5-dibenzyloxybenzamide for detection purposes, and a method for detecting fluoride ions using the compound as a ratiometric fluorescent probe. Background technique [0002] Anions widely exist in biological systems and play important roles in the fields of biology, chemistry, medicine, and environmental science. Therefore, people are increasingly interested in the selective identification and detection of anions. Among many anions, fluoride ion is the anion with the strongest electronegativity and the smallest ionic radius. It exists widely in nature and is also one of the essential trace elements for the human body. Due to its significant role in the fields of dental caries prevention and osteoporosis treatment received special attention. However, excessiv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D277/66C09K11/06G01N21/64
CPCC07D277/66C09K11/06C09K2211/1007C09K2211/1014C09K2211/1037G01N21/643
Inventor 尹静梅崔颖娜贾颖萍李慎敏
Owner DALIAN UNIV
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