Method for preparing compound Ganmaoling granules

Abstract

The invention discloses a method for preparing compound Ganmaoling granules, which is characterized by comprising the following steps: a, pretreating, to be specific, cutting herba viticis, thin evodia twig and leaf, and scaly holly root into sections with length of about 2-15 cm, cutting baphicacanthus root into sections with length of about 3-30 cm, and bagging wild honeysuckle flower and wild chrysanthemum flower; b, extracting, to be specific, adding all the medicinal materials into a boiling and extracting tank in sequence, firstly, adding the scaly holly root and the herba viticis into the tank, then wild honeysuckle flower and wild chrysanthemum flower, and finally, adding the thin evodia twig and leaf and the baphicacanthus root into the tank; c, refining, to be specific, cooling the fluid extract to a temperature of 30-50 DEG C, adding ethanol to enable the ethanol content to reach 60-65 %, stirring evenly, allowing standing for 12-24 hours, filtering, and concentrating the filtrate into a thick extract with a relative density of 1.17-1.26 at a temperature of 70-80 DEG C; d, preparing, to be specific, adopting wet granulation, one-step granulation, high-speed extrusion granulation, spheronization granulation or spray granulation.

Description

technical field [0001] The invention relates to a preparation method of compound Ganmaoling granule. Background technique [0002] Compound Ganmaoling Granules are widely used. They are mainly used for pungent and cool solution, clearing heat and detoxification, fever caused by wind-heat cold and febrile disease, slight aversion to wind-cold, head and body pain, dry mouth and thirst, stuffy nose, sore throat, cough , yellow and sticky phlegm and other diseases, especially for the treatment of colds, headaches, fever and other physical conditions. Moreover, the use of traditional Chinese medicine as raw materials will not increase the burden on the stomach, especially will not damage the liver. Compared with western medicines, which are easy to cause drug resistance in the human body, make patients dependent on drugs, and damage body functions to varying degrees, it has significant advantages. [0003] As we all know, the compound weight ratio of compound Ganmaoling granule...

AI Technical Summary

Problems solved by technology

[0005] There are following problems in the above preparation method: 1. each Chinese medicine composition in the product granule is inhomogeneous, mainly shows that the particle color difference between batches and batches is large, and the uniformity of chlorpheniramine maleate is low; Low, mainly manifested in fenugreek and chlorogenic acid; ③Food paste often freezes during storage, resulting in difficulty in granulation and large granule color difference; ④The solubility of the product is unqualified, and insolubles often appear; ⑤The yield of the product is low , only around 70%