Method for preparing compound Ganmaoling granules

A technology of Ganmaoling and Granules, which is applied in the field of preparation of Compound Ganmaoling Granules, can solve the problems of low extraction and transfer rate of active ingredients of Chinese herbal medicines, low uniformity of chlorpheniramine maleate, unqualified product solubility, etc. Consumer perception is good, the quality is stable, the performance is the best, and the product color and luster are uniform and the effect is high

Inactive Publication Date: 2019-02-01
华润三九(郴州)制药有限公司
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Problems solved by technology

[0005] There are following problems in the above preparation method: 1. each Chinese medicine composition in the product granule is inhomogeneous, mainly shows that the particle color difference between batches and batches is large, and the uniformity of chlorpheniramine maleate is low; Low, m

Method used

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Embodiment Construction

[0058] The present invention is described in detail below:

[0059] The preparation method of compound Ganmaoling granule of the present invention is characterized in that comprising the steps:

[0060] a. Pre-treatment: cut five-finger mandarin orange, three-fork bitterness, and gang plum into sections of about 2-15cm, cut the root of Nanbanlan into sections of about 3-30cm, pack mountain silver flower and wild chrysanthemum into bags;

[0061] b. Extraction: put each medicinal material into the cooking pot in order: first put Gangmei and five-finger mandarin orange, then put mountain silver flower and wild chrysanthemum, and finally put Sanchaku and Nanbanlangen;

[0062] Add water to extract twice: add water 4-5 times the total weight of medicinal materials for the first time, control the temperature at 90-100°C, control the steam pressure at 0.12-0.20MPa during the heating process, and control the steam pressure at 0.04-0.12 during the boiling process MP, after extracting...

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Abstract

The invention discloses a method for preparing compound Ganmaoling granules, which is characterized by comprising the following steps: a, pretreating, to be specific, cutting herba viticis, thin evodia twig and leaf, and scaly holly root into sections with length of about 2-15 cm, cutting baphicacanthus root into sections with length of about 3-30 cm, and bagging wild honeysuckle flower and wild chrysanthemum flower; b, extracting, to be specific, adding all the medicinal materials into a boiling and extracting tank in sequence, firstly, adding the scaly holly root and the herba viticis into the tank, then wild honeysuckle flower and wild chrysanthemum flower, and finally, adding the thin evodia twig and leaf and the baphicacanthus root into the tank; c, refining, to be specific, cooling the fluid extract to a temperature of 30-50 DEG C, adding ethanol to enable the ethanol content to reach 60-65 %, stirring evenly, allowing standing for 12-24 hours, filtering, and concentrating the filtrate into a thick extract with a relative density of 1.17-1.26 at a temperature of 70-80 DEG C; d, preparing, to be specific, adopting wet granulation, one-step granulation, high-speed extrusion granulation, spheronization granulation or spray granulation.

Description

technical field [0001] The invention relates to a preparation method of compound Ganmaoling granule. Background technique [0002] Compound Ganmaoling Granules are widely used. They are mainly used for pungent and cool solution, clearing heat and detoxification, fever caused by wind-heat cold and febrile disease, slight aversion to wind-cold, head and body pain, dry mouth and thirst, stuffy nose, sore throat, cough , yellow and sticky phlegm and other diseases, especially for the treatment of colds, headaches, fever and other physical conditions. Moreover, the use of traditional Chinese medicine as raw materials will not increase the burden on the stomach, especially will not damage the liver. Compared with western medicines, which are easy to cause drug resistance in the human body, make patients dependent on drugs, and damage body functions to varying degrees, it has significant advantages. [0003] As we all know, the compound weight ratio of compound Ganmaoling granule...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K36/754A61K9/16A61P11/00A61K31/167A61K31/4402A61K31/522
CPCA61K9/1623A61K31/167A61K31/4402A61K31/522A61K36/185A61K36/195A61K36/287A61K36/315A61K36/355A61K36/752A61K36/754A61K36/85A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P11/00A61K2300/00
Inventor 龚小兵陈海刚李军戚建中陈光建符国成
Owner 华润三九(郴州)制药有限公司
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