The invention discloses a method for preparing compound Ganmaoling granules, which is characterized by comprising the following steps: a, pretreating, to be specific, cutting herba viticis, thin evodia twig and leaf, and scaly holly root into sections with length of about 2-15 cm, cutting baphicacanthus root into sections with length of about 3-30 cm, and bagging wild honeysuckle flower and wild chrysanthemum flower; b, extracting, to be specific, adding all the medicinal materials into a boiling and extracting tank in sequence, firstly, adding the scaly holly root and the herba viticis into the tank, then wild honeysuckle flower and wild chrysanthemum flower, and finally, adding the thin evodia twig and leaf and the baphicacanthus root into the tank; c, refining, to be specific, cooling the fluid extract to a temperature of 30-50 DEG C, adding ethanol to enable the ethanol content to reach 60-65 %, stirring evenly, allowing standing for 12-24 hours, filtering, and concentrating the filtrate into a thick extract with a relative density of 1.17-1.26 at a temperature of 70-80 DEG C; d, preparing, to be specific, adopting wet granulation, one-step granulation, high-speed extrusion granulation, spheronization granulation or spray granulation.